Results 81 to 90 of about 5,879 (222)

Structural Characterization and AI‐Enhanced Modeling of a Broadly Neutralizing Camelid Antibody Against SARS‐CoV‐2 Variants

Advanced Therapeutics, Volume 9, Issue 1, January 2026.
This study characterizes a camelid antibody (B10) with potent neutralizing activity against SARS‐CoV‐2 Wildtype and Omicron variants. Through binding assays, epitope mapping, pseudovirus neutralization, and AI‐driven modeling, the antibody is shown to target conserved RBD regions in a closed Spike conformation.
Katja Hanack, Urszula Orzeł, Anja Schlör, Sourabh Mehta, Anandi Krishnan, Slawomir Filipek, Rushika Patel, Madhvi Joshi, Markus Hoffmann, Stefan Pöhlmann, Chaitanya Joshi, Dorian Liepmann, Ramasamy Paulmurugan, Venkatesan Renugopalakrishnan   +13 more
wiley   +1 more source

Production of Hepatitis B Viral Antigens and Antibodies using Phage Display Technology for the Development of a Diagnostic Test [PDF]

, 2006
Hepatitis B is one of the most common infectious diseases in the world. It is caused by the hepatitis B virus (HBV) which is estimated to infect more than one third of the world's population and there are about 400 million carriers of HBV worldwide ...
Tan, Geok Hun
core  

Use of Peptide Libraries for Identification and Optimization of Novel Antimicrobial Peptides. [PDF]

, 2016
The increasing rates of resistance among bacteria and to a lesser extent fungi have resulted in an urgent need to find new molecules that hold therapeutic promise against multidrug-resistant strains.
Ashby, M, Gani, J, Hilpert, K, Mikut, R, Petkova, A   +4 more
core   +1 more source

Continuous Suppression of Pathological Retinal and Choroidal Neovascularization in Cynomolgus Monkeys via Noninvasive Ophthalmic Delivery of a Novel Anti‐VEGFA Nanobody and Proprietary Penetratin Analog Formulation

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Pathological retinal/choroidal neovascularization drives vision loss in DR and AMD. Current anti‐VEGF injections, while effective, require invasive, frequent administration. Pene/LQ015, is developed a novel topical anti‐VEGFA nanobody formulation achieving therapeutic intraocular levels through penetratin analog‐enhanced delivery.
Chong Chen, Min Zhu, Xingyan Fan, Kangjia Lv, Kuan Jiang, Yuchen Zhang, Haoliang Zhang, Xinming Qi, Benjamin TK Lee, Yakun Wan, Gang Wei, Kun Liu, Xun Xu   +12 more
wiley   +1 more source

A Comparative Study Of Antibody Responses In Tst+ And Tst- Groups With Long Term Exposure To Mycobacterium Tuberculosis [PDF]

, 2017
Tuberkulosis (TB) merupakan penyakit yang disebar oleh Mycobacterium tuberculosis (MTB) melalui udara. Secara tradisinya T-sel diberikan penekanan yang utama dalam pengantaraan jangkitan MTB dengan sedikit penekanan diberikan kepada B-sel dan antibody
Chin, Siang Tean
core  

Exosome‐Based Cartilage‐Targeted Delivery System: Strategies and Applications

Small Science, Volume 6, Issue 1, January 2026.
Construction strategies and applications of cartilage‐targeting exosomes. With the ageing of the global population, cartilage‐related diseases, such as osteoarthritis (OA) and intervertebral disc degeneration (IVDD), have increasingly become significant social problems threatening human health. Therefore, targeted therapy for cartilage is becoming more
Yao Wang, Bo Chen, Haodong Zhu, Zhenyu Sun   +3 more
wiley   +1 more source

Identification of Novel Single Chain Fragment Variable Antibodies Against TNF-α Using Phage Display Technology [PDF]

Advanced Pharmaceutical Bulletin, 2015
Purpose: Tumor necrosis factor alpha (TNF-α) is an inflammatory cytokine, involved in both physiological and pathological pathways. Because of central role of TNF-α in pathogenesis of inflammatory diseases, in the current study, we aimed to identify ...
Ali Akbar Alizadeh, Maryam Hamzeh-Mivehroud, Siavoush Dastmalchi   +2 more
doaj   +1 more source

A Sustainable Biotechnology Approach for Mineral Separation

Advanced Functional Materials, Volume 35, Issue 50, December 9, 2025.
Silver‑binding peptides are first identified through phage‐display screening, and then engineered into multifunctional and responsive peptides or proteins. These tailored biomolecules can selectively capture and aggregate silver particles or ions from complex mixtures, enabling rapid and efficient silver separation and recovery.
Guangze Yang, Yun Liu, Shankar Raj Devkota, Yue Hui, Ruilin Zhao, Yang Li, David A. Weitz, Chun‐Xia Zhao   +7 more
wiley   +1 more source

Improving Pharmacokinetics of Peptides Using Phage Display

Viruses
Phage display is a versatile method often used in the discovery of peptides that targets disease-related biomarkers. A major advantage of this technology is the ease and cost efficiency of affinity selection, also known as biopanning, to identify novel ...
Mallika Asar, Jessica Newton-Northup, Mette Soendergaard   +2 more
doaj   +1 more source

Phage display selected magnetite interacting Adhirons for shape controlled nanoparticle synthesis [PDF]

, 2015
Adhirons are robust, well expressing, peptide display scaffold proteins, developed as an effective alternative to traditional antibody binding proteins for highly specific molecular recognition applications.
Bramble, Jonathan P., Cooke, David J., McPherson, Michael J., Monnington, Amy E., Rawlings, Andrea E., Somner, Lori A., Staniland, Sarah S., Tang, Anna A. S., Tomlinson, Darren C.   +8 more
core   +2 more sources