Results 61 to 70 of about 3,391 (172)

Improving Pharmacokinetics of Peptides Using Phage Display

Viruses
Phage display is a versatile method often used in the discovery of peptides that targets disease-related biomarkers. A major advantage of this technology is the ease and cost efficiency of affinity selection, also known as biopanning, to identify novel ...
Mallika Asar, Jessica Newton-Northup, Mette Soendergaard   +2 more
doaj   +1 more source

Identification of Novel Single Chain Fragment Variable Antibodies Against TNF-α Using Phage Display Technology [PDF]

Advanced Pharmaceutical Bulletin, 2015
Purpose: Tumor necrosis factor alpha (TNF-α) is an inflammatory cytokine, involved in both physiological and pathological pathways. Because of central role of TNF-α in pathogenesis of inflammatory diseases, in the current study, we aimed to identify ...
Ali Akbar Alizadeh, Maryam Hamzeh-Mivehroud, Siavoush Dastmalchi   +2 more
doaj   +1 more source

Nanobody–chlorin e6 conjugate for Nectin‐4‐mediated tumor targeting and enhanced photodynamic therapy

VIEW, Volume 7, Issue 3, June 2026.
Nectin‐4 is frequently overexpressed in solid tumors, yet many PDT photosensitizers show poor water solubility and nonspecific uptake. A Nectin‐4‐targeted nanobody–chlorin e6 conjugate (NPC) improves aqueous solubility and selectively accumulates in Nectin‐4‐positive tumor cells.
Haodian Wan, Tao Ye, Yawei Bi, Jiayu Zhang, Wei Wu, Aochi Liu, Li Sun, Jie Lin, Ningli Chai, Manjie Zhang, Jian Ma   +10 more
wiley   +1 more source

Development of CAR Exosomes Targeting FAP for the Treatment of Intrauterine Adhesion

Journal of Extracellular Vesicles, Volume 15, Issue 5, May 2026.
ABSTRACT Engineered extracellular vesicles (EVs) have emerged as promising cell‐free platforms for immunomodulation and tissue repair. In this study, we generated EVs derived from chimeric antigen receptor (CAR) T cells targeting fibroblast activation protein (FAP) and investigated their biological and therapeutic functions.
Wenyan Fu, Kewen Qian, Hongru Ai, Yitan Zou, Yaping Zhou, Ruixue Mao, Jian Zhao, Changhai Lei, Shi Hu   +8 more
wiley   +1 more source

Generation of human TMEM16F-specific affibodies using purified TMEM16F

Frontiers in Molecular Biosciences
Introduction: TMEM16 family proteins are involved in a variety of functions, including ion transport, phospholipid scrambling, and the regulation of membrane proteins. Among them, TMEM16F has dual functions as a phospholipid scramblase and a nonselective
Eunyoung Kim, Jinho Bang, Jinho Bang, Ji Hye Sung, Jonghwan Lee, Dae Hwan Shin, Sunghyun Kim, Byoung-Cheol Lee   +7 more
doaj   +1 more source

Peptide‐Incorporated Biomaterials Promote Regeneration of Peripheral Nerve Injuries

Advanced Science, Volume 13, Issue 23, 23 April 2026.
Peptide‐incorporated biomaterials provide precise, tunable biological cues that mimic functional protein domains to regulate behaviors of neurons, Schwann cells, immune cells, and endothelial cells, thereby enhancing axon elongation, Schwann cell support, inflammatory microenvironment modulation, and vascularization, offering a promising alternative to
Zhiwei Zhao, Jianfeng Liu, Jincheng Li, Di Li, Jianxun Ding, Bin Liu   +5 more
wiley   +1 more source

Nanobody‐Mediated c‐MYC Degradation Inhibits Tumor Cell Progression

MedComm, Volume 7, Issue 4, April 2026.
A cell‐permeable nanobody strategy was developed to target the intrinsically disordered oncoprotein c‐MYC. A synthetic nanobody, M4, binds the central PEST region of c‐MYC (241–263) and promotes c‐MYC degradation by enhancing Thr58 phosphorylation. Conjugation of M4 to a cell‐penetrating peptide (CPP) generates CPM4, which efficiently accumulates in ...
Yuanyuan Xue, Hao Jiang, Zhaoyun Zong, Xiaolin Tian, Zelong Miao, Ting Li, Yali Wei, Haiteng Deng   +7 more
wiley   +1 more source

Unraveling the Roots of Selectivity of Peptide Affinity Reagents for Structurally Similar Ribosomal Inactivating Protein Derivatives

Molecules, 2016
Peptide capture agents have become increasingly useful tools for a variety of sensing applications due to their ease of discovery, stability, and robustness.
Deborah A. Sarkes, Margaret M. Hurley, Dimitra N. Stratis-Cullum   +2 more
doaj   +1 more source

Engineered CAR‐NKT Extracellular Vesicles Suppress Tumor Progression and Enhance Antitumor Immunity

Advanced Science, Volume 13, Issue 13, 3 March 2026.
TM4SF1‐nanobody engineered CAR‐natural killer T–derived extracellular vesicles (CARTM4SF1‐EVs) provide a cell‐free alternative to CAR‐NKT therapy, achieving potent, targeted antitumor activity with reduced toxicity. CARTM4SF1‐EVs induce immunogenic cell death, remodel the tumor microenvironment, and enhance CD8⁺ T‐cell antitumor immunity.
Xiaopei Hao, Chengming Qu, Yanzhao Zhou, Xiaoqian Wang, Xiangjun Qian, Xun Chen, Feng Han, Xiaokai Zhang, Yiyi Ji, Han Li, ChengWei Ju, Peng Xia, Weiwei Tang, Hao Zhuang, Jinxue Zhou   +14 more
wiley   +1 more source

Selection and Characterization of Single Domain Antibodies Specific for Bacillus anthracis Spore Proteins

Antibodies, 2013
To obtain thermostable immunoreagents specific for the spore form of Bacillus anthracis two llamas were immunized with a combination of six different recombinant proteins.
P. Audrey Brozozog Lee, George P. Anderson, Ellen R. Goldman, Scott A. Walper   +3 more
doaj   +1 more source