Results 41 to 50 of about 4,252 (213)

Mimotopes selected by biopanning with high-titer HIV-neutralizing antibodies in plasma from Chinese slow progressors

Brazilian Journal of Infectious Diseases, 2012
OBJECTIVE: One approach to identifying HIV-1 vaccine candidates is to dissect the natural antiviral immune response in treatment-naïve individuals infected for over ten years, considered slow progressor patients (SPs).
Xiaoli Zhang, Xiaoxu Han, Di Dai, Bao Mingjia, Zining Zhang, Min Zhang, Tristan Bice, Min Zhao, Yaming Cao, Hong Shang   +9 more
doaj   +1 more source

Characterization of the Binding Behavior of Specific Cobalt and Nickel Ion-Binding Peptides Identified by Phage Surface Display

Separations, 2022
In recent years, the application focus of phage surface display (PSD) technology has been extended to the identification of metal ion-selective peptides. In previous studies, two phage clones—a nickel-binding one with the peptide motif CNAKHHPRCGGG and a
Sabine Matys, Lisa-Marie Morawietz, Franziska Lederer, Katrin Pollmann   +3 more
doaj   +1 more source

Phage Display Derived Monoclonal Antibodies: From Bench to Bedside

Frontiers in Immunology, 2020
Monoclonal antibodies (mAbs) have become one of the most important classes of biopharmaceutical products, and they continue to dominate the universe of biopharmaceutical markets in terms of approval and sales.
Mohamed A. Alfaleh, Mohamed A. Alfaleh, Hashem O. Alsaab, Ahmad Bakur Mahmoud, Almohanad A. Alkayyal, Martina L. Jones, Martina L. Jones, Stephen M. Mahler, Stephen M. Mahler, Anwar M. Hashem, Anwar M. Hashem   +10 more
doaj   +1 more source

Expression of anti-Z-DNA single chain antibody variable fragment on the filamentous phage surface

Brazilian Journal of Medical and Biological Research, 2000
We describe the expression of an anti-Z-DNA single chain variable region antibody fragment (scFv) on a filamentous phage surface. Four vectors for phage display were constructed.
A.Q. Maranhão, M.M. Brígido
doaj   +1 more source

Biosensor-based high throughput biopanning and bioinformatics analysis strategy for the global validation of drug-protein interactions

, 2020
Receptors and enzyme proteins are important biomolecules that act as binding targets for bioactive small molecules. Thus, the rapid and global validation of the drug-protein interactions is highly desirable for not only understanding the molecular ...
Yoichi, Takakusagi, Takakusagi, Yoichi, 1013496, 1013497   +3 more
core   +1 more source

Bacteriophages as Therapeutic and Diagnostic Vehicles in Cancer

Pharmaceuticals, 2021
Evolution of nanomedicine is the re-design of synthetic and biological carriers to implement novel theranostic platforms. In recent years, bacteriophage research favors this process, which has opened up new roads in drug and gene delivery studies.
Valentina Foglizzo, Serena Marchiò
doaj   +1 more source

Identification of Functional mimotopes of human Vasorin Ectodomain by Biopanning [PDF]

International Journal of Biological Sciences, 2018
Human vasorin (VASN) as a type I transmembrane protein, is a potential biomarker of hepatocellular carcinoma, which could expedite HepG2 cell proliferation and migration significantly in vitro. The ectodomain of VASN was proteolytically released to generate soluble VASN (sVASN), which was validated to be the active form.
Li, Da, Zhang, Tan, Yang, Xiqin, Geng, Jie, Li, Shaohua, Ding, Hongmei, Li, Hui, Huang, Aixue, Wang, Chaonan, Sun, Leqiao, Bai, Chenjun, Zhang, Heqiu, Li, Jie, Dong, Jie, Shao, Ningsheng   +14 more
openaire   +2 more sources

Sheep polyclonal antibody to map Haemonchus contortus mimotopes using phage display library

Revista Brasileira de Parasitologia Veterinária, 2018
The aim of this study was to evaluate phage display technology for mapping Haemonchus contortus mimotopes. We screened the PhD-7 Phage Display Peptide Library Kit with a sheep polyclonal antibody against H. contortus.
Andréia Buzatti, Arnielis Diaz Fernandez, Amilcar Arenal, Erlán Pereira, Alda Lucia Gomes Monteiro, Marcelo Beltrão Molento   +5 more
doaj   +1 more source

Astrochemistry on the EXPOSE/ISS and BIOPAN/Foton experiments [PDF]

Proceedings of the International Astronomical Union, 2009
AbstractWe describe three space experiments designed to expose to space conditions, and more specifically to solar UV radiation, selected samples of organic and mineral material.
Cottin, H., Guan, Y. Y., Coll, Patrice, Coscia, David, Fray, N., Macari, F., Stalport, F., Raulin, François, Szopa, Cyril, Chaput, D., Viso, M., Bertrand, M., Chabin, A., Westall, F., Brack, A.   +14 more
openaire   +2 more sources

Application of Next Generation Sequencing (NGS) in Phage Displayed Peptide Selection to Support the Identification of Arsenic-Binding Motifs

Viruses, 2020
Next generation sequencing (NGS) in combination with phage surface display (PSD) are powerful tools in the newly equipped molecular biology toolbox for the identification of specific target binding biomolecules. Application of PSD led to the discovery of
Robert Braun, Nora Schönberger, Svenja Vinke, Franziska Lederer, Jörn Kalinowski, Katrin Pollmann   +5 more
doaj   +1 more source