Results 31 to 40 of about 3,391 (172)

Identification of Functional mimotopes of human Vasorin Ectodomain by Biopanning [PDF]

International Journal of Biological Sciences, 2018
Human vasorin (VASN) as a type I transmembrane protein, is a potential biomarker of hepatocellular carcinoma, which could expedite HepG2 cell proliferation and migration significantly in vitro. The ectodomain of VASN was proteolytically released to generate soluble VASN (sVASN), which was validated to be the active form.
Li, Da, Zhang, Tan, Yang, Xiqin, Geng, Jie, Li, Shaohua, Ding, Hongmei, Li, Hui, Huang, Aixue, Wang, Chaonan, Sun, Leqiao, Bai, Chenjun, Zhang, Heqiu, Li, Jie, Dong, Jie, Shao, Ningsheng   +14 more
openaire   +2 more sources

Bacteriophages as Therapeutic and Diagnostic Vehicles in Cancer

Pharmaceuticals, 2021
Evolution of nanomedicine is the re-design of synthetic and biological carriers to implement novel theranostic platforms. In recent years, bacteriophage research favors this process, which has opened up new roads in drug and gene delivery studies.
Valentina Foglizzo, Serena Marchiò
doaj   +1 more source

Examining the Interactome of Huperzine A by Magnetic Biopanning

PLoS ONE, 2012
Huperzine A is a bioactive compound derived from traditional Chinese medicine plant Qian Ceng Ta (Huperzia serrata), and was found to have multiple neuroprotective effects. In addition to being a potent acetylcholinesterase inhibitor, it was thought to act through other mechanisms such as antioxidation, antiapoptosis, etc.
Wei Guo, Shupeng Liu, Jinliang Peng, Xiaohui Wei, Ye Sun, Yangsheng Qiu, Guangwei Gao, Peng Wang, Yuhong Xu   +8 more
openaire   +4 more sources

Sheep polyclonal antibody to map Haemonchus contortus mimotopes using phage display library

Revista Brasileira de Parasitologia Veterinária, 2018
The aim of this study was to evaluate phage display technology for mapping Haemonchus contortus mimotopes. We screened the PhD-7 Phage Display Peptide Library Kit with a sheep polyclonal antibody against H. contortus.
Andréia Buzatti, Arnielis Diaz Fernandez, Amilcar Arenal, Erlán Pereira, Alda Lucia Gomes Monteiro, Marcelo Beltrão Molento   +5 more
doaj   +1 more source

Application of Next Generation Sequencing (NGS) in Phage Displayed Peptide Selection to Support the Identification of Arsenic-Binding Motifs

Viruses, 2020
Next generation sequencing (NGS) in combination with phage surface display (PSD) are powerful tools in the newly equipped molecular biology toolbox for the identification of specific target binding biomolecules. Application of PSD led to the discovery of
Robert Braun, Nora Schönberger, Svenja Vinke, Franziska Lederer, Jörn Kalinowski, Katrin Pollmann   +5 more
doaj   +1 more source

Strategies to Screen Anti-AQP4 Antibodies from Yeast Surface Display Libraries

Antibodies, 2022
A rapid and effective method to identify disease-specific antibodies from clinical patients is important for understanding autoimmune diseases and for the development of effective disease therapies.
Aric Huang, Wei Jin, Ahmed S. Fahad, Brooklyn K. Mussman, Grazia Paola Nicchia, Bharat Madan, Matheus Oliveira de Souza, J. Daniel Griffin, Jeffrey L. Bennett, Antonio Frigeri, Cory J. Berkland, Brandon J. DeKosky   +11 more
doaj   +1 more source

Astrochemistry on the EXPOSE/ISS and BIOPAN/Foton experiments [PDF]

Proceedings of the International Astronomical Union, 2009
AbstractWe describe three space experiments designed to expose to space conditions, and more specifically to solar UV radiation, selected samples of organic and mineral material.
Cottin, H., Guan, Y. Y., Coll, Patrice, Coscia, David, Fray, N., Macari, F., Stalport, F., Raulin, François, Szopa, Cyril, Chaput, D., Viso, M., Bertrand, M., Chabin, A., Westall, F., Brack, A.   +14 more
openaire   +2 more sources

GPCR-Based Bioactive Peptide Screening Using Phage-Displayed Peptides and an Insect Cell System for Insecticide Discovery

Biomolecules, 2021
The discovery of new insecticides improves integrated pest management (IPM), but is usually a long high-risk process with a low probability of success.
Man-Yeon Choi, Robert K. Vander Meer
doaj   +1 more source

Novel Biopanning Strategy To Identify Epitopes Associated with Vaccine Protection [PDF]

Journal of Virology, 2013
ABSTRACTIdentifying immune correlates of protection is important to develop vaccines against infectious diseases. We designed a novel, universally applicable strategy to profile the antibody (Ab) repertoire of protected vaccine recipients, using recombinant phages encoding random peptide libraries.
Barbara C, Bachler, Michael, Humbert, Brisa, Palikuqi, Nagadenahalli B, Siddappa, Samir K, Lakhashe, Robert A, Rasmussen, Ruth M, Ruprecht   +6 more
openaire   +2 more sources

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

Advanced Science, EarlyView.
A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li, Muyang Li, Lei Sun, Ying Yang, Yuanshun Wu, Ziyi Yin, Anni Wang, Peiyang Zhou, Shaoxiang Luo, Jian Chen, Jun Qin, Zhibing Ai, Zilong Yuan, Zhiqiang Dong, Min Zhang   +14 more
wiley   +1 more source