Results 91 to 100 of about 5,879 (222)
Advanced Therapeutics, Volume 8, Issue 12, December 2025.This review explores how antibody engineering and display technologies are driving therapeutic advances against mosquito‐borne orthoflaviviruses such as Zika, dengue, and yellow fever viruses. It highlights diverse neutralizing targets on the envelope protein, including the conserved fusion loop, and discusses how Fc engineering, rational antigen ...
Ana Clara Barbosa Antonelli +5 more
wiley +1 more source
Blood-brain barrier shuttle peptides: an emerging paradigm for brain delivery [PDF]
, 2017 Brain delivery is one of the major challenges in drug development because of the high number of patients suffering from neural diseases and the low efficiency of the treatments available.
Giralt Lledó, Ernest +3 more
core +1 more source
Emerging Biosensor Technologies for Stroke Biomarker Detection: A Comprehensive Overview
Analytical Science Advances, Volume 6, Issue 2, December 2025.ABSTRACT Stroke remains a leading cause of morbidity and mortality worldwide, necessitating the development of rapid and reliable diagnostic tools for early detection and management. This manuscript presents an overview of innovative biosensors designed for the detection of key stroke biomarkers, including N‐terminal pro B‐type natriuretic peptide (NT ...
Ghazal Koohkansaadi +3 more
wiley +1 more source
Advanced Science, Volume 12, Issue 44, November 27, 2025.This study developed mAb‐5F2, a monoclonal antibody targeting conserved GP4 residues (Q48/I50), which blocks the GP4‐CD163 interaction, resulting in a 78–85% reduction in viral entry. Porcineized 5F2‐pFc prevented mortality in infected piglets, reduced pulmonary viral loads, and minimized lesions. This broad‐spectrum antibody platform overcomes vaccine
Xu Chen +12 more
wiley +1 more source
Generation of human TMEM16F-specific affibodies using purified TMEM16F
Frontiers in Molecular BiosciencesIntroduction: TMEM16 family proteins are involved in a variety of functions, including ion transport, phospholipid scrambling, and the regulation of membrane proteins. Among them, TMEM16F has dual functions as a phospholipid scramblase and a nonselective
Eunyoung Kim +7 more
doaj +1 more source
Peptide Ligands that Interact with Newcastle Disease Virus: Selection, Characterization and Applications [PDF]
, 2003 Newcastle disease, a highly contagious disease of the avian species is caused by the Newcastle disease virus (NOV). In Malaysia there have been 29 outbreaks of NOV reported this year alone.
Thurai Raja, Priadarishni Ramanujam
core
Improving Cry8Ka toxin activity towards the cotton boll weevil (Anthonomus grandis) [PDF]
, 2011 Background The cotton boll weevil (Anthonomus grandis) is a serious insect-pest in the Americas, particularly in Brazil. The use of chemical or biological insect control is not effective against the cotton boll weevil because of its endophytic life style.
Gustavo R Oliveira +12 more
core +1 more source
European Journal of Inorganic Chemistry, Volume 28, Issue 27, September 29, 2025.Two new platinum‐binding peptides are identified by phage display against Pt‐{100} and polycrystalline targets. Binding free energies (ΔG) are quantified on Pt‐{111} surfaces using a quartz crystal microbalance with dissipation monitoring. Synchrotron radiation circular dichroism (SRCD) reveals facet‐dependent conformational adaptation on cubic (Pt ...
Monika Michaelis +3 more
wiley +1 more source
Antibody-Based Protective Immunity against Helminth Infections: Antibody Phage Display Derived Antibodies against BmR1 Antigen [PDF]
, 2017 Helminth parasite infections are significantly impacting global health, with more than two billion infections worldwide with a high morbidity rate. The complex life cycle of the nematodes has made host immune response studies against these parasites ...
Abdul Karim, Izzati Zahidah +3 more
core +2 more sources
The Prostate, Volume 85, Issue 13, Page 1208-1221, September 15, 2025.ABSTRACT Background N‐terminus 15 amino acid (MC16) of Annexin A1 (ANXA1) is an effective therapeutic target for tumors and tumor vasculature as it specifically localizes to the cell surface of tumor cells and tumor vascular endothelial cells. We identified the d‐type peptide (hpnevrs, dhp7) by mirror‐image phage display targeting l‐type MC16 and ...
Kai Ozaki +8 more
wiley +1 more source