Results 91 to 100 of about 4,252 (213)

Structural Characterization and AI‐Enhanced Modeling of a Broadly Neutralizing Camelid Antibody Against SARS‐CoV‐2 Variants

Advanced Therapeutics, Volume 9, Issue 1, January 2026.
This study characterizes a camelid antibody (B10) with potent neutralizing activity against SARS‐CoV‐2 Wildtype and Omicron variants. Through binding assays, epitope mapping, pseudovirus neutralization, and AI‐driven modeling, the antibody is shown to target conserved RBD regions in a closed Spike conformation.
Katja Hanack, Urszula Orzeł, Anja Schlör, Sourabh Mehta, Anandi Krishnan, Slawomir Filipek, Rushika Patel, Madhvi Joshi, Markus Hoffmann, Stefan Pöhlmann, Chaitanya Joshi, Dorian Liepmann, Ramasamy Paulmurugan, Venkatesan Renugopalakrishnan   +13 more
wiley   +1 more source

Continuous Suppression of Pathological Retinal and Choroidal Neovascularization in Cynomolgus Monkeys via Noninvasive Ophthalmic Delivery of a Novel Anti‐VEGFA Nanobody and Proprietary Penetratin Analog Formulation

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Pathological retinal/choroidal neovascularization drives vision loss in DR and AMD. Current anti‐VEGF injections, while effective, require invasive, frequent administration. Pene/LQ015, is developed a novel topical anti‐VEGFA nanobody formulation achieving therapeutic intraocular levels through penetratin analog‐enhanced delivery.
Chong Chen, Min Zhu, Xingyan Fan, Kangjia Lv, Kuan Jiang, Yuchen Zhang, Haoliang Zhang, Xinming Qi, Benjamin TK Lee, Yakun Wan, Gang Wei, Kun Liu, Xun Xu   +12 more
wiley   +1 more source

Branched Polyethylenimine as a Carrier for Significantly Improving the Biopanning Efficiency of Phages Specific to Hapten

Unlike macromolecule-specific phage biopanning, traditional phage biopanning specific to small molecules (hapten) often faces the dilemma of low efficiency due to the low hapten density and non-target-specific binding attributed to the protein carriers ...
Jianxin Sui (9771749), Yuan Chen (9740), Guoqiang Li (417937), Tianjiao Zhang (469586), Xiangning Han (6444050), Limin Cao (407556), Hong Lin (46089), Chang Liu (35901)   +7 more
core   +1 more source

Generation of human TMEM16F-specific affibodies using purified TMEM16F

Frontiers in Molecular Biosciences
Introduction: TMEM16 family proteins are involved in a variety of functions, including ion transport, phospholipid scrambling, and the regulation of membrane proteins. Among them, TMEM16F has dual functions as a phospholipid scramblase and a nonselective
Eunyoung Kim, Jinho Bang, Jinho Bang, Ji Hye Sung, Jonghwan Lee, Dae Hwan Shin, Sunghyun Kim, Byoung-Cheol Lee   +7 more
doaj   +1 more source

Exosome‐Based Cartilage‐Targeted Delivery System: Strategies and Applications

Small Science, Volume 6, Issue 1, January 2026.
Construction strategies and applications of cartilage‐targeting exosomes. With the ageing of the global population, cartilage‐related diseases, such as osteoarthritis (OA) and intervertebral disc degeneration (IVDD), have increasingly become significant social problems threatening human health. Therefore, targeted therapy for cartilage is becoming more
Yao Wang, Bo Chen, Haodong Zhu, Zhenyu Sun   +3 more
wiley   +1 more source

A Fully Human Derived Monoclonal Antibody Provides Potent Pre‐ and Postexposure Protection Against Rabies Virus

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Rabies remains a critical global health concern, particularly in endemic regions where timely access to postexposure prophylaxis (PEP) is often limited. The effectiveness of PEP relies heavily on rabies immune globulin (RIG), yet plasma‐derived products continue to face persistent issues of limited supply, variable potency, and high cost.
Ruo Mo, Jingqi Xu, Huanqin Zheng, Tianyi Yin, Haiyang Cong, Lugong Chen, Feihu Yan, Na Feng, Tiecheng Wang, Jianzhong Wang, Yongkun Zhao, Xianzhu Xia, Francesco Mira   +12 more
wiley   +1 more source

Summary of outcomes of phage display biopanning of MAP WCA and EEA with sequences selected for MS evaluation highlighted.

, 2016
Summary of outcomes of phage display biopanning of MAP WCA and EEA with sequences selected for MS evaluation highlighted.
Lorna M. O’Brien (2185822), Sam A. J. Strain (2185825), Linda D. Stewart (385246), Irene R. Grant (385249)   +3 more
core   +1 more source

Unraveling the Roots of Selectivity of Peptide Affinity Reagents for Structurally Similar Ribosomal Inactivating Protein Derivatives

Molecules, 2016
Peptide capture agents have become increasingly useful tools for a variety of sensing applications due to their ease of discovery, stability, and robustness.
Deborah A. Sarkes, Margaret M. Hurley, Dimitra N. Stratis-Cullum   +2 more
doaj   +1 more source

A Sustainable Biotechnology Approach for Mineral Separation

Advanced Functional Materials, Volume 35, Issue 50, December 9, 2025.
Silver‑binding peptides are first identified through phage‐display screening, and then engineered into multifunctional and responsive peptides or proteins. These tailored biomolecules can selectively capture and aggregate silver particles or ions from complex mixtures, enabling rapid and efficient silver separation and recovery.
Guangze Yang, Yun Liu, Shankar Raj Devkota, Yue Hui, Ruilin Zhao, Yang Li, David A. Weitz, Chun‐Xia Zhao   +7 more
wiley   +1 more source

Schematic of phage display biopanning regime adopted in order to generate L. monocytogenes-specific binders.

, 2013
Schematic of phage display biopanning regime adopted in order to generate L. monocytogenes-specific binders.
Christopher T. Elliott (407641), Josephine Morton (456813), Nitsara Karoonuthaisiri (107618), Linda D. Stewart (385246), Ratthaphol Charlermroj (407634), Irene R. Grant (385249)   +5 more
core   +1 more source