Results 11 to 20 of about 71,391 (320)

Transgenic animal bioreactors. [PDF]

Transgenic research, 2000
The production of recombinant proteins is one of the major successes of biotechnology. Animal cells are required to synthesize proteins with the appropriate post-translational modifications. Transgenic animals are being used for this purpose. Milk, egg white, blood, urine, seminal plasma and silk worm cocoon from transgenic animals are candidates to be
L. M. Houdebine
openalex   +5 more sources

Preparative‐Scale Biocatalytic Oxygenation of N‐Heterocycles with a Lyophilized Peroxygenase Catalyst

Angewandte Chemie, Volume 135, Issue 5, January 26, 2023., 2023
A lyophilized preparation of an unspecific peroxygenase variant from Agrocybe aegerita (rAaeUPO‐PaDa‐I‐H) is a highly effective catalyst for the oxygenation of a diverse range of N‐heterocyclic compounds. Scalable, high yielding and enantioselective biocatalytic oxygenations have been developed, including 27 preparative examples (ca.
Balázs Pogrányi, Tamara Mielke, Alba Díaz‐Rodríguez, Jared Cartwright, William P. Unsworth, Gideon Grogan   +5 more
wiley   +2 more sources

Multi-omics integrative analysis with genome-scale metabolic model simulation reveals global cellular adaptation of Aspergillus niger under industrial enzyme production condition

Scientific Reports, 2018
Oxygen limitation is regarded as a useful strategy to improve enzyme production by mycelial fungus like Aspergillus niger. However, the intracellular metabolic response of A. niger to oxygen limitation is still obscure. To address this, the metabolism of
Hongzhong Lu, Weiqiang Cao, Xiaoyun Liu, Yufei Sui, Liming Ouyang, Jianye Xia, Mingzhi Huang, Yingping Zhuang, Siliang Zhang, Henk Noorman, Ju Chu   +10 more
doaj   +1 more source

Efficient generation of male germ-like cells derived during co-culturing of adipose-derived mesenchymal stem cells with Sertoli cells under retinoic acid and testosterone induction

Stem Cell Research & Therapy, 2019
Background Adipose-derived mesenchymal stem cells (ADMSCs) are considered an efficient and important candidate for male infertility treatment because they contain pluripotent stem cells, which can differentiate into all cells from three germ layers ...
Yanxia Luo, Lili Xie, Ali Mohsin, Waqas Ahmed, Chenze Xu, Yan Peng, Haifeng Hang, Yingping Zhuang, Ju Chu, Meijin Guo   +9 more
doaj   +1 more source

Electrochemical ammonia production from nitrates in agricultural tile drainage: Technoeconomic and global warming analysis

AIChE Journal, Volume 69, Issue 2, February 2023., 2023
Abstract Nitrates from agricultural wastewater are harmful to human health and result in eutrophication. Several emerging electrochemical technologies have been developed independently to enable efficient recovery and recycling of nitrate waste; however, it remains unclear whether the implementation of such combined technologies can be economically ...
Sharmila Samaroo, David P. Hickey
wiley   +1 more source

Sensing of cytosolic LPS through caspy2 pyrin domain mediates noncanonical inflammasome activation in zebrafish

Nature Communications, 2018
In humans, caspase-5 is an LPS sensor that can induce gasdermin D cleavage and pyroptosis. Here, the authors show that zebrafish caspy2 is a functional homolog as it also senses cytosolic LPS to activate the noncanonical inflammasome and to protect ...
Dahai Yang, Xin Zheng, Shouwen Chen, Zhuang Wang, Wenting Xu, Jinchao Tan, Tianjian Hu, Mingyu Hou, Wenhui Wang, Zhaoyan Gu, Qiyao Wang, Ruilin Zhang, Yuanxing Zhang, Qin Liu   +13 more
doaj   +1 more source

Mixomics analysis of Bacillus subtilis: effect of oxygen availability on riboflavin production

Microbial Cell Factories, 2017
Background Riboflavin, an intermediate of primary metabolism, is one kind of important food additive with high economic value. The microbial cell factory Bacillus subtilis has already been proven to possess significant importance for the food industry ...
Junlang Hu, Pan Lei, Ali Mohsin, Xiaoyun Liu, Mingzhi Huang, Liang Li, Jianhua Hu, Haifeng Hang, Yingping Zhuang, Meijin Guo   +9 more
doaj   +1 more source

Dynamic response of Aspergillus niger to single pulses of glucose with high and low concentrations

Bioresources and Bioprocessing, 2019
Microorganisms generally encounter a fluctuating environment in their natural habitat and similar conditions also happen in large-scale bioreactors. In this work, the dynamic response of intracellular and extracellular metabolites of Aspergillus niger ...
Shuai Wang, Peng Liu, Wei Shu, Chao Li, Huan Li, Shanshan Liu, Jianye Xia, Henk Noorman   +7 more
doaj   +1 more source

Mechanism of Zn2+ regulation of cellulase production in Trichoderma reesei Rut-C30

Biotechnology for Biofuels and Bioproducts, 2023
Background Trichoderma reesei Rut-C30 is a hypercellulolytic mutant strain that degrades abundant sources of lignocellulosic plant biomass, yielding renewable biofuels.
Ni Li, Jing Li, Yumeng Chen, Yaling Shen, Dongzhi Wei, Wei Wang   +5 more
doaj   +1 more source

PI-controlled bioreactor as a generalized Lienard system [PDF]

Computers and Chem. Eng. 31 (2007) 136-141, 2005
It is shown that periodic orbits can occur in Cholette's bioreactor model working under the influence of a PI-controller. We find a diffeomorphic coordinate transformation that turns this controlled enzymatic reaction system into a generalized Lienard form.
arxiv   +1 more source