Results 11 to 20 of about 2,460 (195)

A Convenient Synthesis of 3,7′-Bisindole Derivatives [PDF]

Molecules, 2016
An efficient and convenient method to synthesize highly functionalized 3,7′-bisindole derivatives has been developed via a Michael addition and cyclic condensation reaction of heterocyclic ketene aminals (HKAs) with 2-(1H-indol-3-yl)cyclohexa-2,5-diene-1,
Teng Liu, Hong-You Zhu, Da-Yun Luo, Sheng-Jiao Yan, Jun Lin   +4 more
doaj   +3 more sources

Design, Synthesis and Application of Chiral Spirocyclic Bisindoles

Angewandte Chemie
AbstractWhile modifications of the privileged catalyst backbones, such as 1,1’‐spirobiindane‐7,7’‐diol (SPINOL), have led to the development of diverse useful chiral catalysts, the incorporation of heteroarenes in such chiral spirocyclic structures has limitedly known.
Jing‐Yi Wang, Jianwei Sun
wiley   +4 more sources

Rapid Access to an Enantioenriched Spiro Bisindole Directly from Indole and Acetone. [PDF]

Angew Chem Int Ed Engl
A catalytic enantioselective one‐pot “self‐assembly” strategy was developed for the exceedingly convenient access to a spiro bisindole directly from indole and acetone. The obtained enantiopure C2‐symmetric bisindole showed exceptional performance as a chiral backbone of diverse effective catalysts or ligands. Abstract Disclosed here is a “one‐pot self‐
Wang JY, Lin J, Zhang C, Sun J.
europepmc   +3 more sources

Combined Transcriptomic and Metabolomic Analysis Reveals an Ethylene-Activated Regulatory Model on Monoterpenoid Indole Alkaloid Biosynthesis in Catharanthus roseus. [PDF]

Plant Biotechnol J
ABSTRACT Catharanthus roseus contains nearly 200 bioactive monoterpenoid indole alkaloids (MIAs) that are effective in treating cancer and other diseases. Ethylene plays a significant role in enhancing MIA biosynthesis, and we have found that it greatly induces the accumulation of anhydrovinblastine.
Deng B, Miao Q, Ou C, Pan Y, Liu H, Fu X, Li L, Wang Y, Tang K, Pan Q.   +9 more
europepmc   +2 more sources

Bisindoles. 21. Synthesis and alkylation of some tetramethyl-substituted bisindoles [PDF]

Chemistry of Heterocyclic Compounds, 1985
2,3,2′,3′-Tetramethyl-substituted bisindoles and their 1,1′-dimethyl derivatives were synthesized. The latter were obtained in high yield by interphase alkylation of the bisindoles. The spectral characteristics of the synthesized bisindoles were studied.
M. G. Chesmaritashvili, Sh. A. Samsoniya, E. A. Ageev, E. N. Gordeev, L. N. Kuleshova, T. A. Kozik, N. N. Suvorov   +6 more
  +6 more sources

Bisindole alkaloids from Voacanga grandifolia leaves

Journal of Natural Medicines, 2021
Two new bisindole alkaloids, 12'-O-demethyl-vobtusine-5-lactam and isovobtusine-N-oxide (1 and 2), were isolated from the leaves of Voacanga grandifolia, together with two known bisindole alkaloids. Their structures were elucidated on the basis of 1D and 2D NMR data. 1 and 2 showed potent antimalarial activity against Plasmodium falciparum 3D7 and very
Alfarius Eko Nugroho, -, Yurika Ono, -, Eunji Jin, -, Yusuke Hirasawa, -, Toshio Kaneda, -, Abdul Rahman, -, Idha Kusumawati, -, Takahiro Tougan, -, Toshihiro Horii, -, Noor Cholies Zaini, -, Hiroshi Morita, -   +10 more
openaire   +3 more sources

Dimethyl 3,3′-[(4-nitrophenyl)methylene]bis(1H-indole-2-carboxylate) ethanol hemisolvate

IUCrData, 2021
There are two main molecules in asymmetric unit of the title compound, C27H21N3O6·0.5C2H5OH. In both, the indole ring systems are approximately perpendicular to each other, at dihedral angles of 69.3 (5) and 82.8(4)°. In the crystal, molecules are linked
Yu-Long Li, Jin Zhou, Hong Jiang, Hong-Shun Sun, Rui-Zhe Li, Sha-Li Liu, Xu-Dong Zhang   +6 more
doaj   +1 more source

Novel Small-Molecule Hybrid-Antibacterial Agents against S. aureus and MRSA Strains

Molecules, 2021
Ongoing resistance developments against antibiotics that also affect last-resort antibiotics require novel antibacterial compounds. Strategies to discover such novel structures have been dimerization or hybridization of known antibacterial agents.
Robin Gehrmann, Tobias Hertlein, Elisa Hopke, Knut Ohlsen, Michael Lalk, Andreas Hilgeroth   +5 more
doaj   +1 more source

Diethyl 3,3′-[(3-fluorophenyl)methylene]bis(1H-indole-2-carboxylate)

IUCrData, 2020
In the title compound, C29H25FN2O4, the mean planes of the indole ring systems are approximately perpendicular to one another [dihedral angle = 88.3 (4)°]. The benzene ring is twisted with respect to the indole ring systems by 49.8 (5) and 77.6 (3)°.
Hong Jiang, Yu-Long Li, Jin Zhou, Hong-Shun Sun, Qing-Yu Zhang, Xing-Hao Shi, Zhi-Yuan Zhang, Tian Ling   +7 more
doaj   +1 more source

Halophiles and Their Biomolecules: Recent Advances and Future Applications in Biomedicine [PDF]

, 2020
The organisms thriving under extreme conditions better than any other organism living on Earth, fascinate by their hostile growing parameters, physiological features, and their production of valuable bioactive metabolites.
Amoozegar, Mohammad Ali, Corral Villa, Paulina, Ventosa Ucero, Antonio   +2 more
core   +1 more source