Isatin Bis-Indole and Bis-Imidazothiazole Hybrids: Synthesis and Antimicrobial Activity
Molecules, 2022 Isatin and its derivatives are important heterocycles found in nature and present in numerous bioactive compounds which possess various biological activities. Moreover, it is an essential building block in organic synthesis.
Francesca Bonvicini +4 more
doaj +1 more source
Synthetic Analogues of the Snail Toxin 6-Bromo-2-mercaptotryptamine Dimer (BrMT) Reveal That Lipid Bilayer Perturbation Does Not Underlie Its Modulation of Voltage-Gated Potassium Channels [PDF]
, 2018 Drugs do not act solely by canonical ligand–receptor binding interactions. Amphiphilic drugs partition into membranes, thereby perturbing bulk lipid bilayer properties and possibly altering the function of membrane proteins.
Aldrich, Richard W. +12 more
core +2 more sources
Synthesis of New Methoxy Actived Mono and Bis-indole Compounds
Hittite Journal of Science and Engineering, 2022 An indole hydrazone has successfully been synthesized employing Schiff base reaction conditions starting from 4,6-dimethoxy-2,3-diphenylindole-7-carbaldehyde with hydrazine hydrate.
Hakan Kandemir
doaj +1 more source
Facilitating biomimetic syntheses of borrerine derived alkaloids by means of flow-chemical methods [PDF]
, 2015 Flow chemistry is widely used nowadays in synthetic chemistry and has increasingly been applied to complex natural product synthesis. However, to date flow chemistry has not found a place in the area of biomimetic synthesis.
Kamptmann, SB, Ley, SV
core +1 more source
The Potential Roles of Long Noncoding RNAs (lncRNA) in Glioblastoma Development [PDF]
, 2016 Long noncoding RNA (lncRNA) may contribute to the initiation and progression of tumor. In this study, we first systematically compared lncRNA and mRNA expression between glioblastoma and paired normal brain tissues using microarray data.
Eischen, Christine M. +6 more
core +2 more sources
A new approach for the synthesis of bisindoles through AgOTf as catalyst
Beilstein Journal of Organic Chemistry, 2014 A novel approach for the catalyzed formation of bisindolylmethane derivatives (BIMs) is described. This methodology is the unique example where AgOTf has been successfully used for the activation of aldehydes, giving easy access to a broad range of ...
Jorge Beltrá +2 more
doaj +1 more source
Applied Microbiology, 2023 Heterocyclic compounds can specifically regulate bacterial development by targeting specific bacterial enzymes and metabolic pathways. The ESKAPE pathogens are multidrug-resistant and cause nosocomial infections, which is one of the greatest challenges ...
Lisha K. Poonacha +12 more
doaj +1 more source
A Mild and General Larock Indolization Protocol for the Preparation of Unnatural Tryptophans [PDF]
, 2016 A mild and general protocol for the Pd(0)-catalyzed heteroannulation of o-bromoanilines and alkynes is described. Application of a Pd(0)/P(^tBu)_3 catalyst system enables the efficient coupling of o-bromoanilines at 60 °C, mitigating deleterious side ...
Chuang, Kangway V. +2 more
core +2 more sources
Oxidative Rearrangements of the Alkaloid Intermediate Geissoschizine
Angewandte Chemie, Volume 137, Issue 24, June 10, 2025.19E‐geissoschizine is a key precursor in the biosynthesis of monoterpene indole alkaloids such as strychnine, ibogaine, and vinblastine. Using enzymatic assays and gene silencing, three CYPs were identified from C. roseus that oxidize this compound to four alkaloid scaffolds: strychnos, sarpagan, akuammiline, and mavacurane. Mutational analysis reveals
Mohamed O. Kamileen +6 more
wiley +2 more sources
Combined Application of Bacterial Predation and Violacein to Kill Polymicrobial Pathogenic Communities [PDF]
, 2017 Violacein is a bisindole antibiotic that is effective against Gram-positive bacteria while the bacterial predator, Bdellovibrio bacteriovorus HD100, predates on Gram-negative strains. In this study, we evaluated the use of both together against multidrug
Choi, Seong Yeol +3 more
core +2 more sources