Bioactive Bis(indole) Alkaloids from a Spongosorites sp. Sponge
Marine Drugs, 2020 Six new bis(indole) alkaloids (1–6) along with eight known ones of the topsentin class were isolated from a Spongosorites sp. sponge of Korea. Based on the results of combined spectroscopic analyses, the structures of spongosoritins A–D (1–4) were ...
Jae Sung Park +9 more
doaj +1 more source
3-[4-(1H-indol-3-yl)-1,3-thiazol-2-yl]-1H-pyrrolo[2,3-b]pyridines, nortopsentin Analogues with antiproliferative activity [PDF]
, 2015 A new series of nortopsentin analogues, in which the imidazole ring of the natural product was replaced by thiazole and the indole unit bound to position 2 of the thiazole ring was substituted by a 7-azaindole moiety, was efficiently synthesized.
Attanzio, A. +11 more
core +2 more sources
Antemitotic activity of strychnopentamine, a bisindolic alkaloid
Journal of Ethnopharmacology, 1984 Strychnopentamine has been tested for its cytotoxic and antitumor activities and compared with two other bisindolic alkaloids that possess an usambarane skeleton. The presence of a N-methylpyrrolidine group increases the antimitotic activity of this type of alkaloids.
Tits, Monique +4 more
openaire +3 more sources
Cloning and Overexpression of Strictosidine β-D-Glucosidase Gene Short Sequence from Catharanthus roseus in Escherichia coli [PDF]
Advanced Pharmaceutical Bulletin, 2019 Purpose: Strictosidine-β-D-glucosidase (SGD) is considered as a key enzyme in the production of bisindole alkaloids in Catharanthus roseus. The present study illustrated the production of a short sequence of this enzyme in Escherichia coli without codon ...
Ahmed Saeed Arafa +4 more
doaj +1 more source
The Janthinobacterium sp. HH01 genome encodes a homologue of the V. cholerae CqsA and L. pneumophila LqsA autoinducer synthases [PDF]
, 2013 Janthinobacteria commonly form biofilms on eukaryotic hosts and are known to synthesize antibacterial and antifungal compounds. Janthinobacterium sp. HH01 was recently isolated from an aquatic environment and its genome sequence was established.
Blokesch, Melanie +20 more
core +4 more sources
Marine bisindole alkaloid: A potential apoptotic inducer in human cancer cells
European Journal of Histochemistry, 2018 Marine organisms such as corals, sponges and tunicates produce active molecules which could represent a valid starting point for new drug development processes.
Sara Salucci +8 more
doaj +1 more source
Eight Indole Alkaloids from the Roots of Maerua siamensis and Their Nitric Oxide Inhibitory Effects
Molecules, 2022 Maerua siamensis (Capparaceae) roots are used for treating pain and inflammation in traditional Thai medicine. Eight new indole alkaloids, named maeruanitriles A and B, maeroximes A–C, and maeruabisindoles A–C, were isolated from them.
Sasiwimon Nukulkit +7 more
doaj +1 more source
Natural AChE inhibitors from plants and their contribution to Alzheimer´s disease therapy [PDF]
, 2013 As acetylcholinesterase (AChE) inhibitors are an important therapeutic strategy in Alzheimer's disease, efforts are being made in search of new molecules with anti-AChE activity.
Alza, Natalia Paola +4 more
core +2 more sources
Marine Drugs, 2019 The composition of the culture medium has great influence on the metabolite production of the marine fungus Pseudallescheria boydii F44-1. By adding amino acids to GPY culture medium, two new bisindole alkaloids, pseudboindoles A and B (1 and 2 ...
Mei-Xiang Yuan +7 more
doaj +1 more source
Antimicrobial activities of secondary metabolites of endophytic fungi isolated from Catharanthus roseus [PDF]
, 2017 Introduction: Recently, several endophytes have been shown to possess the potentials to synthesize novel bioactive compounds that have found use for drug discovery. We isolated endophytic fungi associated with Catharanthus roseus collected from the river
Abba, Chika C. +6 more
core +2 more sources