Results 61 to 70 of about 2,460 (195)
Biochemistry Research International, Volume 2026, Issue 1, 2026.Type 2 diabetes mellitus (T2DM) is a state where the body’s glucose metabolism is compromised. AMP‐activated protein kinase, or AMPK, has an important part to play in glucose metabolism, and the liver kinase B1 (LKB1) protein functions as a major upstream kinase for AMPK activation, thereby making it appealing therapeutic targets for treating and ...
Rumman Reza +6 more
wiley +1 more source
Synthesis, anti-leishmanial and molecular docking study of bis-indole derivatives
BMC Chemistry, 2019 We have synthesized new series of bisindole analogs (1–27), characterized by 1HNMR and HR-EI-MS and evaluated for their anti-leishmanial potential. All compounds showed outstanding inhibitory potential with IC50 values ranging from 0.7 ± 0.01 to 13.30 ...
Muhammad Taha +10 more
doaj +1 more source
Stimuli-Responsive Metal-Ligand Assemblies. [PDF]
, 2015 The Engineering and Physical Sciences Research Council and the European Research Council are acknowledged for financial support.This is the accepted manuscript of a paper published in Chemical Reviews (McConnell AJ, Wood CS, Neelakandan PP, Nitschke JR ...
McConnell, Anna J +3 more
core +2 more sources
ChemistryOpen, Volume 14, Issue 11, November 2025.Arenaria serpyllifolia extract exhibits strong antioxidant, antimicrobial, antibiofilm, and antiquorum sensing activities. Key compounds, including levoglucosan and guanosine, show potent CviR receptor binding. Violacein inhibition and molecular dynamics confirm their stability, highlighting their potential as quorum sensing inhibitors and therapeutic ...
Meryem Burcu Külahcı +5 more
wiley +1 more source
Brominated Bisindole Alkaloids from the Celtic Sea Sponge Spongosorites calcicola
Molecules, 2019 As part of an ongoing program to identify new bioactive compounds from Irish marine bioresources, we selected the subtidal sponge Spongosorites calcicola for chemical study, as fractions of this species displayed interesting cytotoxic bioactivities and ...
Laurence K. Jennings +6 more
doaj +1 more source
Molecules, 2021 Bisindoles are structurally complex dimers and are intriguing targets for partial and total synthesis. They exhibit stronger biological activity than their corresponding monomeric units.
Kamal P. Pandey +2 more
doaj +1 more source
Synthesis, bioactivity evaluation and computational studies of bisindolylmethane and flavone derivatives / Syahrul Imran Abu Bakar [PDF]
, 2001 Bisindolylmethane and flavone are well-known natural product scaffolds having important pharmacophores and they have gained tremendous interest owing to their remarkable potency and activity profile towards various target diseases.
Abu Bakar, Syahrul Imran
core +6 more sources
CHIMIA, 2014 Trigonoliimines are hexacyclic bisindole alkaloids isolated recently by Hao and co-workers. A synthesis of (±)-trigonoliimine B was accomplished in seven steps from simple starting materials featuring the Bischler-Napieralski reaction for ...
Thomas Buyck, Qian Wang, Jieping Zhu
doaj +1 more source
Mitotic cell death induction by targeting the mitotic spindle with tubulin-inhibitory indole derivative molecules [PDF]
, 2017 Tubulin-targeting molecules are widely used cancer therapeutic agents. They inhibit microtubule-based structures, including the mitotic spindle, ultimately preventing cell division.
Coluccia, Antonio +10 more
core +1 more source
Bioresources and Bioprocessing, 2022 Indirubin is a bisindole compound for the treatment of chronic myelocytic leukemia. Here, we presented a structure-guided method to improve the activity of a flavin-containing monooxygenase (bFMO) for the efficient production of indirubin in Escherichia ...
Bing-Yao Sun +10 more
doaj +1 more source