Results 81 to 90 of about 2,460 (195)

Advances in the Study of Necroptosis in Vascular Dementia: Focus on Blood–Brain Barrier and Neuroinflammation

CNS Neuroscience &Therapeutics, Volume 31, Issue 2, February 2025.
Neuroinflammation and blood–brain barrier disruption play key roles in the progression of vascular dementia, and necroptosis is closely associated with vascular dementia. This review guides the prevention and treatment of vascular dementia by discussing the tumor necrosis factor‐α signaling pathway, destruction of endothelial cells, glial cells, and ...
Yuemin Qiu, Lin Cheng, Yinyi Xiong, Ziying Liu, Chunxiao Shen, Liangliang Wang, Yujia Lu, Shufei Wei, Lushun Zhang, Seung Bum Yang, Xiaorong Zhang   +10 more
wiley   +1 more source

Phosphorus-sulfur heterocycles incorporating an O-P(S)-O or O-P(S)-S-S-P(S)-O scaffold : one-pot synthesis and crystal structure study [PDF]

, 2017
The authors are grateful to the University of St Andrews for financial support.A new one-pot preparative route was developed to synthesize novel organophosphorus sulfur heterocycles via the reaction of the four-membered ring thionation reagent [2,4 ...
Cordes, David B., Davidson, Kate, Du, Junyi, Hua, Guoxiong, Slawin, Alexandra M. Z., Woollins, J. Derek   +5 more
core   +2 more sources

The Therapeutic Effects of Bioactive Compounds on Colorectal Cancer via PI3K/Akt/mTOR Signaling Pathway: A Critical Review

Food Science &Nutrition, Volume 12, Issue 12, Page 9951-9973, December 2024.
This study discussed the therapeutic capacity of various polyphenols, terpenoids, and alkaloids on CRC via the PI3K/Akt/mTOR pathway. Each bioactive component causes various physiological processes, such as triggering free radical production, disruption of mitochondrial membrane potential, cell cycle arrest, inhibition of CRC stem cell migration ...
Kübra Demir, Rana Turgut, Selcen Şentürk, Handan Işıklar, Elif Günalan   +4 more
wiley   +1 more source

A Facile Synthesis of Deaza-Analogues of the Bisindole Marine Alkaloid Topsentin

Molecules, 2013
A series of substituted ethyl 1-[(tert-butoxycarbonyl)amino]-2-methyl-5- (1-methyl-1H-indol-3-yl)-4-[(1-methyl-1H-indol-3-yl)carbonyl]-1H-pyrrole-3-carboxylates were prepared in excellent yields (82-98%) by one-pot reactions between β-dicarbonyl ...
Gianfranco Favi, Cristina Ciancimino, Barbara Parrino, Orazio A. Attanasi, Virginia Spanò, Anna Carbone   +5 more
doaj   +1 more source

Biosynthesis of Arcyriaflavin F from Streptomyces venezuelae ATCC 10712

ChemBioChem, Volume 25, Issue 20, October 16, 2024.
We report the characterisation of the Streptomyces venezuelae ATCC 10712 arcyriaflavin F biosynthetic gene cluster. We express the gene cluster using Streptomyces coelicolor M1152 as a heterologous host, isolate the product and confirm distinct C‐5/C‐5’ indole ring hydroxylation catalysed by a regioselective flavoprotein AcfX. Abstract Indolocarbazoles
Hung‐En Lai, Agata Kennedy, Lewis Tanner, Emma A. Bartram, Soo Mei Chee, Paul S. Freemont, Simon J. Moore   +6 more
wiley   +1 more source

The β-carboline alkaloid harmine inhibits telomerase activity of MCF-7 cells by down-regulating hTERT mRNA expression accompanied by an accelerated senescent phenotype [PDF]

, 2013
The end replication problem, which occurs in normal somatic cells inducing replicative senescence, is solved in most cancer cells by activating telomerase.
Albino, Astulla, Bargonetti, Betts, Bodnar, Boeira, Bradford, Burge, Burger, Cao, Clarke, Elmore, Farnebo, Funayama, Gewirtz, Glennon, Gollahon, Gorbunova, Greenberg, Gualberto, Hamsa, Holt, Im, Ji, Jones, Kim, Kim, Kusumoto, Kyo, Lansiaux, Levine, Liu, Meyerson, Moura, Möller, Nakamura, Noureini, Oh, Roberts, Rosenkranz, Sasaki, Shammas, Shammas, Shay, Shay, Shay, Song, Song, Sourkes, Tanaka, Tweedie, Wang, Wang, Wink, Wink, Wink, Wink, Wu, Xu, Zhao   +59 more
core   +1 more source

Stability of a Mutualistic Escherichia coli Co‐Culture During Violacein Production Depends on the Kind of Carbon Source

Engineering in Life Sciences, Volume 24, Issue 10, October 2024.
ABSTRACT The L‐tryptophan–derived purple pigment violacein (VIO) is produced in recombinant bacteria and studied for its versatile applications. Microbial synthetic co‐cultures are gaining more importance as efficient factories for synthesizing high‐value compounds.
Simon Schick, Tobias Müller, Ralf Takors, Georg A. Sprenger   +3 more
wiley   +1 more source

C. elegans-based screen identifies lysosome-damaging alkaloids that induce STAT3-dependent lysosomal cell death

Protein & Cell, 2018
Lysosomes are degradation and signaling centers within the cell, and their dysfunction impairs a wide variety of cellular processes. To understand the cellular effect of lysosome damage, we screened natural small-molecule compounds that induce lysosomal ...
Yang Li, Yu Zhang, Qiwen Gan, Meng Xu, Xiao Ding, Guihua Tang, Jingjing Liang, Kai Liu, Xuezhao Liu, Xin Wang, Lingli Guo, Zhiyang Gao, Xiaojiang Hao, Chonglin Yang   +13 more
doaj   +1 more source

Fishing for Targets of Alien Metabolites: A Novel Peroxisome Proliferator-Activated Receptor (PPAR) Agonist from a Marine Pest [PDF]

, 2018
Although the chemical warfare between invasive and native species has become a central problem in invasion biology, the molecular mechanisms by which bioactive metabolites from invasive pests influence local communities remain poorly characterized.
Amodeo, Pietro, Calignano, Antonio, Carbone, Marianna, Cutignano, Adele, D'Aniello, Biagio, D'Aniello, Enrico, Defranoux, Fanny, Di Marzo, Vincenzo, Felline, Serena, Fellous, Tariq, Gentile, Alessandra, Giuliani, Maria Elisa, Gorbi, Stefania, Grauso, Laura, Magliozzi, Laura, Martella, Andrea, Mollo, Ernesto, Polese, Gianluca, Regoli, Francesco, Silvestri, Cristoforo, Terlizzi, Antonio, Vitale, Rosa Maria   +21 more
core   +1 more source

Bisleuconothine A protects periodontal tissue via the regulation of RANKL expression and infiltration of inflammatory cells [PDF]

, 2020
Purpose: To investigate the protective effect of bisleuconothine A on periodontal tissue in rats and the mechanism involved. Methods: Adult male Sprague Dawley rats (n = 32) weighing 180 - 200 g (mean weight, 190 ± 10 g) were randomly assigned to four ...
Sun, Ping, Sun, Qiang, Wang, Fang
core   +2 more sources