Results 161 to 170 of about 76,436 (252)

AHR‐Responsive Carbon Dots Orchestrate Skin Wound Healing and Colonic Mucosal Repair via Treg‐Mediated Macrophage Efferocytosis

Advanced Science, EarlyView.
Guided by pharmacophore modeling and molecular docking, aryl hydrocarbon receptor (AHR)‐responsive carbon dots were synthesized. They bind directly to AHR and expand gut‐resident regulatory T (Treg) cells. Treg‐derived C‐C motif chemokine ligand 1 (CCL1) enhances macrophage efferocytosis, creating a pro‐regenetative niche that promotes colonic mucosal ...
Zilu Zhu, Han Zhang, Shuai Lin, Wenqian Zheng, Xin Li, Xiaowei Xu, Ruili Yang   +6 more
wiley   +1 more source

Size-Optimized LDH Nanoplatelet-Reinforced GelMA Hydrogels Orchestrate Osteoimmunomodulation for Critical-Sized Bone Defect Repair. [PDF]

Int J Nanomedicine
Zhao M, Yang N, Han Y, Huang J, Xu J, Wu W, Gao X, Ying B, Jia S.   +8 more
europepmc   +1 more source

Design principles of 3D-printed biomaterial scaffolds for bone defect repair: Materials, biological responses and translational barriers

Yanlan Yang, Jinnong Wang, Yang Xiang, Pu Xu, Boming Peng, Wenbo Zhang, Zhongwen Lei   +6 more
openalex   +1 more source

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

Janus Membranes as Multifunctional Nanostructures for Bone Defect Repair: Advances, Challenges, and Clinical Translation. [PDF]

Int J Nanomedicine
Liu J, Liu S, Tan R, Chang W, Chen Z, Wang Y, Zhou P, Sun H, Xu Z.   +8 more
europepmc   +1 more source

An Injectable Metal‐Drug Supramolecular Condensate Enables Radiosensitization and Systemic Antitumor Immunity for Post‐Surgical Osteosarcoma Therapy

Advanced Science, EarlyView.
This work designed an injectable metal‐drug supramolecular condensate formed from hafnium ions and alendronate (Hf‐ALN) and loaded with the COX‐2 inhibitor celecoxib (CXB) for synergistic radioimmunotherapy of postoperative osteosarcoma. Mechanistically, upon X‐ray irradiation, Hf enhances radiation energy deposition, ROS generation, and DNA damage ...
Tianhua Xiao, Zunlei Gong, Chuke Chen, Hui Yu, Yu Cai, Can Liu, Hongkai Huang, Ying Li, Jinyuan Guan, Le Wang, Chengyun Ning, Guoxin Tan, Lei Zhou   +12 more
wiley   +1 more source

Synergistic antibacterial and osteogenic properties of micro-arc oxidation GO@Ag/SF composite coatings for the repair of infectious bone defects

Wanliang Yang, Jingwei Bi, Xinxin Ji, Tian Bai, Zehao Jing, Xingkun Wang, Haoran Chang, Qian Xu, Junhao Lin, Jiguang Tian, Kai Di, Xin Pan, Wenhao Zhou, Hao Li, Teng Zhang   +14 more
openalex   +1 more source

Gut Microbiota‐Derived Indole‐3‐Propionic Acid Alleviates Diabetic Osteoporosis Through Nrf2‐Mediated Ferroptosis Suppression

Advanced Science, EarlyView.
Diabetes‐associated dysbiosis is accompanied by reduced Clostridium abundance, impaired microbial tryptophan metabolism, and lower circulating indole‐3‐propionic acid (IPA). Exogenous IPA improves trabecular microarchitecture and bone formation and restores Nrf2‐associated antioxidant signaling in bone marrow mesenchymal stem cells, limiting iron ...
Jinwu Bai, Qinyong You, Gao Si, Daole Hu, Ao Sun, Shilong Su, Ruideng Wang, Jixing Fan, Shan Gao, Tengjiao Zhu, Chun‐Li Song, Fang Zhou, Yang Lv   +12 more
wiley   +1 more source

A multifunctional EGCG/Si nanohybrid-coated 3D-printed porous scaffold for bone defect repair. [PDF]

Regen Biomater
Xiao S, Qi L, Wei J, Liu H, Ding S, Chen J, Yang J, Lin H, Lu D.   +8 more
europepmc   +1 more source

A dual-targeting mRNA lipid nanoparticle restores ABCA1-dependent cholesterol homeostasis to promote repair of age-related bone defects

Mengze Cheng, Kun Xi, Zhengxia Ni, Lingjun Wang, Jincheng Tang, Wei Wang, Ziang Li, Liang Zhou, Xinzhao Jiang, Jie Wu, Qiangqiang Guo, Yiwei Zhu, Zhengjie Tao, Tianyi Li, Changdong Cui, Wenguo Cui, Liang Chen, Yong Gu   +17 more
openalex   +1 more source