Results 171 to 180 of about 76,436 (252)

Sequential Regulation of Neurovascular Bone Regeneration in Large Bone Defects Using Black Phosphorus‐Europium Nanosheet Integrated TPMS Biomimetic Scaffold with Photo‐Controlled Ion Release

Advanced Science, EarlyView.
TPBE scaffolds, in conjunction with mild photothermal effects, effectively activate the PI3K/Akt signaling cascade, thereby promoting early neuronal differentiation and neurite growth. Short‐term (12 W) in vivo implantation studies revealed no significant pathological damage to major organs, providing preliminary evidence of the material's excellent ...
Bingqian Wang, Yuping Zhang, Xiaoning Su, Ning Liu, Hui Zeng, Bo Yang, Yang Xue, Fang Guo, Changkui Liu   +8 more
wiley   +1 more source

Exosome-enabled bone defect repair: mechanistic foundations, bioengineered delivery, and artificial intelligence-driven translation. [PDF]

J Nanobiotechnology
Yang S, Ge S, Liu Z, Chen J, Chang F, Shen J, Wu F, Sun X, Wang Z, Li Y, Zhang M, Chen R, Feng T, Yin T, Fu P, Chen M, Yin P, Hao L.   +17 more
europepmc   +1 more source

SWIR-responsive SeTe nanoparticles integrate antibacterial activity and selenoprotein-associated redox regulation for infected bone defect repair

Zhencheng Xiong, Xiutao Yang, Chaoyi Zhang, Zhao Zhang, Jin Yang, Man Li, 陈凤发, Yingze Ning, Shanwu Ma, Chutong Lin, Jizheng Tang, Changqing Dong, Jun Wang, Cheng Huang, Jun Gou, Guangliang Qiang   +15 more
openalex   +1 more source

TNAP and PHOSPHO1 Function Synergistically to Afford Critical Control Over the Mineralization of the Postnatal Murine Skeleton

Advanced Science, EarlyView.
Biomineralization underpins skeletal development, yet its molecular control remains incompletely understood. Using a novel murine knockout model, this study reveals the essential and complementary roles of PHOSPHO1 and TNAP in postnatal skeletal development.
Lucie E. Bourne, Aikta Sharma, Scott Dillon, Jacob Keen, Soher N. Jayash, Natalie Crump, Lucinda A.E. Evans, Maya Karmali, Worachet Promruk, Claire E. Clarkin, Sonoko Narisawa, Louise Stephen, Brian L. Foster, José Luis Millán, Colin Farquharson, Katherine A. Staines   +15 more
wiley   +1 more source

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, EarlyView.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

Epigenetic reprogramming periosteum promotes aging critical segmental bone defect repair via methylation remodeling. [PDF]

Bioact Mater
Zheng J, Ke J, Wu S, Lan Y, Zhong Z, Yang S, Zhao N, Wang Z, Chai M, Shi X, Wang Y.   +10 more
europepmc   +1 more source

Comprehensive guideline for X-ray microtomography-guided bone analysis and histology applied to the assessment of defect repair in long and flat bones [PDF]

Bruno Henrique Costa, Isabela Louise Pereira Lopes, M. De Oliveira, Tamires Aparecida Jaques de Resende, Murilo Leone Miranda Fajardo, ANNA BEATRIZ MODESTO PIRES, Anderson Camargo Moreira, Iara Frangiotti Mantovani, Rodrigo Nagata, Talita Martins, Eduardo Henrique Martins Nunes, Taíse Matte Manhabosco, Érika Costa de Alvarenga   +12 more
openalex   +1 more source

3D printed porous tantalum loaded with quercetin-curcumin-piperine PLGA nanoparticles for bone defect repair. [PDF]

Sci Rep
Yu S, Tantai M, Song J, Zhang Y, Zhang Z, Ma H, Lu Z.   +6 more
europepmc   +1 more source

Biomimetic Scaffold‐Based 3D Models for Decoding Cancer Biology and Advancing Therapy

Advanced Science, EarlyView.
A timeline of the research history of 3D biomimetic scaffold materials and platforms. With advances in biomimetic materials and 3D scaffold technologies, their functional scope has expanded from mimicking basic physical and biochemical properties to increasingly replicating complex pathophysiological processes.
Haitao Zhao, Yuechen Han, Jie Li, Peng Luo, Lin Qi, Zhiwei Xia, Xiaosong Li, Quan Cheng, Chenshen Huang, Wantao Wu, Hao Zhang   +10 more
wiley   +1 more source

Biomimetic scaffolds with synergistic BMSC targeting and ROS scavenging for mitochondrial protection and effective bone-defect repair. [PDF]

J Nanobiotechnology
Yao S, Zeng L, Wang H, Liu J, Cao X, Xu Z, Zhang Y, He S, Ye B, Sun T, Guo X.   +10 more
europepmc   +1 more source