Bone morphogenetic protein 4 is involved in cadmium-associated bone damage. [PDF]
Toxicol Sci, 2023 AbstractCadmium (Cd) is a well-characterized bone toxic agent and can induce bone damage via inhibiting osteogenic differentiation. Bone morphogenetic protein (BMP)/SMAD signaling pathway can mediate osteogenic differentiation, but the association between Cd and BMP/SMAD signaling pathway is yet to be illuminated.
Wan Y +12 more
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The serum levels of activin A and bone morphogenetic protein-4 and -6 in patients with fibrodysplasia ossificans progressiva [PDF]
Orphanet Journal of Rare Diseases, 2023 Background Fibrodysplasia ossificans progressiva (FOP) is an ultrarare and disabling genetic disorder of connective tissue characterized by congenital malformation of the great toes, and progressive heterotopic ossification (HO) in soft connective ...
Zhengqin Ye +5 more
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Bone morphogenetic protein 4 alleviates nonalcoholic steatohepatitis by inhibiting hepatic ferroptosis [PDF]
Cell Death Discovery, 2022 Nonalcoholic steatohepatitis (NASH) is a state of simple steatosis that progresses to inflammation and liver injury accompanied by ferroptosis. Bone morphogenetic protein 4 (BMP4) plays an important role in adipogenesis and differentiation, as well as in
Xingchun Wang +6 more
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Bone morphogenetic protein 4 in perivascular adipose tissue ameliorates hypertension through regulation of angiotensinogen [PDF]
Frontiers in Cardiovascular Medicine, 2022 BackgroundPerivascular adipose tissue (PVAT), an active endocrine organ, exerts direct effect on vascular tone through paracrine. Activation of PVAT metabolism plays an inhibitory role in atherosclerosis via secreting relaxing factors.
Wen-Juan Mu +7 more
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Bone morphogenetic protein 4 (BMP4) signaling in retinoblastoma cells [PDF]
International Journal of Biological Sciences, 2010 Bone morphogenetic proteins (BMPs) - expressed in the developing retina - are known to be involved in the regulation of cell proliferation and apoptosis in several tumor entities.
Maike Haubold, Andreas Weise, Harald Stephan, Nicole Dünker
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European Journal of Histochemistry, 2017 We investigated the expressions of bone morphogenetic protein-4 (BMP4) and its receptors, bone morphogenetic protein receptor IA (BMPRIA), bone morphogenetic protein receptor IB (BMPRIB) and bone morphogenetic protein receptor II (BMPRII) in the adult ...
Yuka Maruyama-Koide +3 more
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The Role of Bone Morphogenetic Protein 4 in Microglial Polarization in the Process of Neuropathic Pain [PDF]
Journal of Inflammation Research, 2022 Changqing Liu,1,2,* Qi Sun,1,2,* Junmei Xu,1,2 Weiyun Shen,1,2 Hui Li,1,2 Lin Yang1,2 1Department of Anesthesiology, Second Xiangya Hospital, Central South University, Changsha, Hunan Province, People’s Republic of China; 2Hunan Province Center ...
Liu C, Sun Q, Xu J, Shen W, Li H, Yang L
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Regulation of bone morphogenetic protein 4 on epithelial tissue. [PDF]
J Cell Commun Signal, 2020 Epithelial tissues provide tissue barriers and specialize in organs and glands. When epithelial homeostasis is physiologically or pathologically stimulated, epithelial cells produce mesenchymal cells through the epithelial-mesenchymal transition, forming new tissues, promoting the cure of diseases or leading to illness.
Shen S +5 more
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Platelet Bone Morphogenetic Protein-4 Mediates Vascular Inflammation and Neointima Formation after Arterial Injury [PDF]
Cells, 2021 The purpose of this study is to investigate the role of platelet bone morphogenetic proteins (BMP)-4 during vascular inflammation and remodeling in a mouse model of carotid wire injury. Transgenic mice with a platelet-specific deletion of BMP-4 (BMP4Plt−/
Marietta Jank +9 more
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Bone Morphogenetic Protein-4 Impairs Retinal Endothelial Cell Barrier, a Potential Role in Diabetic Retinopathy [PDF]
Cells, 2023 Bone Morphogenetic Protein 4 (BMP4) is a secreted growth factor of the Transforming Growth Factor beta (TGFβ) superfamily. The goal of this study was to test whether BMP4 contributes to the pathogenesis of diabetic retinopathy (DR). Immunofluorescence of
Noureldien H. E. Darwish +7 more
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