Bone morphogenetic protein 4 alleviates nonalcoholic steatohepatitis by inhibiting hepatic ferroptosis [PDF]
Cell Death Discovery, 2022 Nonalcoholic steatohepatitis (NASH) is a state of simple steatosis that progresses to inflammation and liver injury accompanied by ferroptosis. Bone morphogenetic protein 4 (BMP4) plays an important role in adipogenesis and differentiation, as well as in
Xingchun Wang +6 more
doaj +3 more sources
European Journal of Histochemistry, 2017 We investigated the expressions of bone morphogenetic protein-4 (BMP4) and its receptors, bone morphogenetic protein receptor IA (BMPRIA), bone morphogenetic protein receptor IB (BMPRIB) and bone morphogenetic protein receptor II (BMPRII) in the adult ...
Yuka Maruyama-Koide +3 more
doaj +5 more sources
Therapeutic Potential for Bone Morphogenetic Protein 4 in Human Malignant Glioma
Neoplasia: An International Journal for Oncology Research, 2017 Human glioma, in particular, malignant forms such as glioblastoma exhibit dismal survival rates despite advances in treatment strategies. A population of glioma cells with stem-like features, glioma cancer stem-like cells (GCSCs), contribute to renewal ...
Guifa Xi +4 more
doaj +4 more sources
Bone morphogenetic protein 4 inhibits pulmonary fibrosis by modulating cellular senescence and mitophagy in lung fibroblasts. [PDF]
Eur Respir J, 2022 Background Accumulation of myofibroblasts is critical to fibrogenesis in idiopathic pulmonary fibrosis (IPF). Senescence and insufficient mitophagy in fibroblasts contribute to their differentiation into myofibroblasts, thereby promoting the development ...
Guan R +22 more
europepmc +2 more sources
The serum levels of activin A and bone morphogenetic protein-4 and -6 in patients with fibrodysplasia ossificans progressiva [PDF]
Orphanet Journal of Rare Diseases, 2023 Background Fibrodysplasia ossificans progressiva (FOP) is an ultrarare and disabling genetic disorder of connective tissue characterized by congenital malformation of the great toes, and progressive heterotopic ossification (HO) in soft connective ...
Zhengqin Ye +5 more
doaj +2 more sources
Bone morphogenetic protein 4 in perivascular adipose tissue ameliorates hypertension through regulation of angiotensinogen [PDF]
Frontiers in Cardiovascular Medicine, 2022 BackgroundPerivascular adipose tissue (PVAT), an active endocrine organ, exerts direct effect on vascular tone through paracrine. Activation of PVAT metabolism plays an inhibitory role in atherosclerosis via secreting relaxing factors.
Wen-Juan Mu +7 more
doaj +2 more sources
The Role of Bone Morphogenetic Protein 4 in Microglial Polarization in the Process of Neuropathic Pain [PDF]
Journal of Inflammation Research, 2022 Changqing Liu,1,2,* Qi Sun,1,2,* Junmei Xu,1,2 Weiyun Shen,1,2 Hui Li,1,2 Lin Yang1,2 1Department of Anesthesiology, Second Xiangya Hospital, Central South University, Changsha, Hunan Province, People’s Republic of China; 2Hunan Province Center ...
Liu C, Sun Q, Xu J, Shen W, Li H, Yang L
doaj +2 more sources
Platelet Bone Morphogenetic Protein-4 Mediates Vascular Inflammation and Neointima Formation after Arterial Injury [PDF]
Cells, 2021 The purpose of this study is to investigate the role of platelet bone morphogenetic proteins (BMP)-4 during vascular inflammation and remodeling in a mouse model of carotid wire injury. Transgenic mice with a platelet-specific deletion of BMP-4 (BMP4Plt−/
Marietta Jank +9 more
doaj +2 more sources
Bone Morphogenetic Protein-4 Impairs Retinal Endothelial Cell Barrier, a Potential Role in Diabetic Retinopathy [PDF]
Cells, 2023 Bone Morphogenetic Protein 4 (BMP4) is a secreted growth factor of the Transforming Growth Factor beta (TGFβ) superfamily. The goal of this study was to test whether BMP4 contributes to the pathogenesis of diabetic retinopathy (DR). Immunofluorescence of
Noureldien H. E. Darwish +7 more
doaj +2 more sources
Identification of bone morphogenetic protein 4 in the saliva after the placement of fixed orthodontic appliance [PDF]
Progress in Orthodontics, 2021 Background This study was conducted in order to explore the effects of orthodontic tooth movement (OTM) on the changes of salivary proteome. This prospective observational pilot study recruited 12 healthy teenage boys with malocclusion treated with a ...
Lovorka Grgurevic +6 more
doaj +2 more sources