Bone morphogenetic protein 4 thermosensitive hydrogel inhibits corneal neovascularization by repairing corneal epithelial apical junctional complexes [PDF]
Materials Today BioCorneal neovascularization (CNV) is a heavy attribute of blinding disease changes. Existing medications need numerous infusions and have a limited absorption. Investigating novel drugs with safety, efficacy, and convenience is crucial.
Weijin Nan +7 more
doaj +2 more sources
Bone morphogenetic protein 4 is involved in cadmium-associated bone damage. [PDF]
Toxicol Sci, 2023 AbstractCadmium (Cd) is a well-characterized bone toxic agent and can induce bone damage via inhibiting osteogenic differentiation. Bone morphogenetic protein (BMP)/SMAD signaling pathway can mediate osteogenic differentiation, but the association between Cd and BMP/SMAD signaling pathway is yet to be illuminated.
Wan Y +12 more
europepmc +3 more sources
Bone Morphogenetic Protein 4 Gene Therapy in Mice Inhibits Myeloma Tumor Growth, But Has a Negative Impact on Bone [PDF]
JBMR Plus, 2020 Multiple myeloma is characterized by accumulation of malignant plasma cells in the bone marrow. Most patients suffer from an osteolytic bone disease, caused by increased bone degradation and reduced bone formation.
Marita Westhrin +15 more
doaj +2 more sources
Recombinant Human Bone Morphogenetic Protein 4 [PDF]
Definitions, 2020 M. Feldman
semanticscholar +2 more sources
BMP4 (bone morphogenetic protein 4) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2013 Review on BMP4 (bone morphogenetic protein 4), with data on DNA, on the protein encoded, and where the gene is implicated.
Thériault, BL, Nachtigal, MW
openaire +2 more sources
Interaction between Soluble Type I Receptor for Bone Morphogenetic Protein and Bone Morphogenetic Protein-4 [PDF]
Journal of Biological Chemistry, 1997 Bone morphogenetic proteins (BMPs) are multifunctional proteins that comprise the largest subfamily of the transforming growth factor-beta. These proteins bind to types I and II serine/threonine kinase receptors. Ligand-induced heteromeric dimerization of these receptors is the key event in initiation of biological responses. We report here large-scale
T, Natsume +5 more
openaire +2 more sources
Journal of Tissue Engineering, 2020 Limitation in cell sources for autologous cell therapy has been a recent focus in stem cell therapy and tissue engineering. Among various research advances, direct conversion, or transdifferentiation, is a notable and feasible strategy for the generation
Seung Hyun L Kim +8 more
doaj +1 more source
Bone Morphogenetic Protein 1 Prodomain Specifically Binds and Regulates Signaling by Bone Morphogenetic Proteins 2 and 4 [PDF]
Journal of Biological Chemistry, 2007 Highly purified fractions of bone extracts capable of inducing ectopic bone formation have been reported to contain peptides corresponding to the mature active regions of the TGF-beta-like bone morphogenetic proteins (BMPs) 2-7, and to the prodomain region of the metalloproteinase BMP1.
Reema, Jasuja +6 more
openaire +2 more sources
Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse.
Genes & Development, 1995 Bone morphogenetic protein-4 (BMP-4) is a member of the TGF-beta superfamily of polypeptide signaling molecules, closely related to BMP-2 and to Drosophila decapentaplegic (DPP).
G. Winnier +3 more
semanticscholar +1 more source
Is NO the Answer? The Nitric Oxide Pathway Can Support Bone Morphogenetic Protein 2 Mediated Signaling [PDF]
, 2019 The growth factor bone morphogenetic protein 2 (BMP2) plays an important role in bone development and repair. Despite the positive effects of BMP2 in fracture healing, its use is associated with negative side effects and poor cost effectiveness, partly ...
Bormann, Nicole +5 more
core +1 more source