Results 91 to 100 of about 241,163 (293)

Energy homeostasis : crosstalk between adipose tissue and the human hypothalamus [PDF]

There is a worldwide epidemic of obesity. Weight rise is a consequence of continuous positive energy balance which leads to accumulation of body fat. Recent insights into adipose tissue (AT) biology have led to the conclusion that the adipocyte is not
Kos, Katarina
core  

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

Preclinical Evaluation of a Novel Molecule Targeting Nucleoside Homeostasis to Restore Energy Metabolism and Cognitive Function in Alzheimer's Disease

Pharmacology Research & Perspectives
Alzheimer's disease (AD) is the most prevalent cause of dementia, characterized by progressive cognitive decline and cerebral metabolic impairment. Yet, the therapeutic options for addressing the disease pathogenesis are limited.
Kuo‐Chen Wu, Chien‐Yu Lin, Thanh Tran, Jung‐Hsing Lin, Hsin‐Hsien Yeh, Chin‐Jui Ho, Yijuang Chern, Chun‐Jung Lin   +7 more
doaj   +1 more source

Human metabolic adaptations and prolonged expensive neurodevelopment: A review

, 2008
1. After weaning, human hunter-gatherer juveniles receive substantial (≈3.5-7 MJ day^-1^), extended (≈15 years) and reliable (kin and nonkin food pooling) energy provision. 2. The childhood (pediatric) and the adult human ...
John R. Skoyles
core  

The bioenergetic status relates to dopamine neuron loss in familial PD with PINK1 mutations

, 2012
Mutations in the PINK1 gene cause autosomal recessive familial Parkinson’s disease (PD). The gene encodes a mitochondrial protein kinase that plays an important role in maintaining mitochondrial function and integrity.
Johann Hagenah, Neumaier, Bernd, Roggendorf, J., Julia Roggendorf, Roggendorf, Julia, Johannes C Klein, Hattingen, E., Steinmetz, H., Hagenah, Johann, Hagenah, J., Klein, Johannes C., Eggers, C., Hilker, Rüediger, Klein, Christine, Hattingen, Elke, Klein, C., Fink, Gereon R., Pilatus, U., Ulrich Pilatus, Elke Hattingen, Bernd Neumaier, Klein, Johannes Christian, Baudrexel, S., Hilker, Rüdiger, Eggers, Carsten, Neumaier, B., Hagenah, Johann Meinert, Carsten Eggers, Klein, J., Helmuth Steinmetz, Fink, Gereon Rudolf, Steinmetz, Helmuth, Pilatus, Ulrich, Fink, G., Rüediger Hilker, Baudrexel, Simon, Gereon R Fink, Christine Klein, Hilker, R., Simon Baudrexel   +39 more
core   +1 more source

Intrinsic Photoactive Star ZnPc–Poly(glutamate) Nanoplatforms for Multimodal Glioblastoma Therapy and Brain‐Targeted Delivery

Advanced Functional Materials, EarlyView.
An intrinsic photoactive star‐shaped zinc phtalocyanine‐poly(L‐glutamic acid) (ZnPc‐PGA) nanoplatform for multimodal glioblastoma (GBM) therapy and brain‐targeted elivery. A ZnPc‐PGA‐based multifunctional theranostic nanocarrier platform enables image‐guided, multimodal GBM therapy. ZnPc‐PGA nanocarriers support the integration of fluorescence imaging,
Amina Benaicha‐Fernández, Teodora Ranđelović, Ana Armiñán, Víctor Sebastián, Manuel Fuentes, Cristián Huck‐Iriart, Esther Masiá, Paula Carrascosa‐Marco, Pablo Juanes‐Velasco, Snežana Đorđević, Clara Bayona, Ignacio Ochoa, Maria Medel, Inmaculada Conejos‐Sánchez, María J. Vicent   +14 more
wiley   +1 more source

Nutritional Ketosis Increases NAD+/NADH Ratio in Healthy Human Brain: An in Vivo Study by 31P-MRS

Frontiers in Nutrition, 2018
Ketones represent an important alternative fuel for the brain under glucose hypo-metabolic conditions induced by neurological diseases or aging, however their metabolic consequences in healthy brain remain unclear.
Lijing Xin, Özlem Ipek, Maurice Beaumont, Maya Shevlyakova, Nicolas Christinat, Mojgan Masoodi, Norman Greenberg, Rolf Gruetter, Bernard Cuenoud   +8 more
doaj   +1 more source

Functional Proteomics and Metabolomics of Brain Energy Metabolism in Pathology and Therapy

, 2014
Functional Proteomics and Metabolomics of Brain Energy Metabolism in Pathology and ...
FERRARI, FEDERICA, VILLA, ROBERTO FEDERICO, GORINI, ANTONELLA   +2 more
core  

Gut-brain axis: regulation of glucose metabolism

, 2006
Obesity and type II diabetes mellitus have reached epidemic proportions. From this perspective, knowledge about the regulation of satiety and food intake is more important than ever.
Heijboer, A. C., Pijl, H., Romijn, J. A., Havekes, L. M., Corssmit, E. P. M., Corssmit, E. P.M., van den Hoek, A. M.   +6 more
core   +1 more source

Periphery-Brain Interactions and Leptin in the Regulation of Whole-Body Energy Metabolism

, 2022
In order to combat overweight and obesity as a global public health issue and prevent its impact on other debilitating cardiovascular, metabolic and renal diseases, a better understanding of the processes regulating energy metabolism are essential [...
Bruneau Jr., Michael, Mohammed Khair Hankir, Hankir, Mohammed Khair, Michael Bruneau   +3 more
core   +1 more source