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Brain organoids: Establishment and application
Frontiers in Cell and Developmental Biology, 2022 Brain organoids are produced by the differentiation of pluripotent stem cells under three-dimensional culture conditions by adding neurodevelopment-related regulatory signals. They are similar to the cell composition and anatomical structure of the brain,
Hao Chen, Xin Jin, Tie Li, Zhuang Ye
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Brain Organoids and Assembloids—From Disease Modeling to Drug Discovery [PDF]
CellsBrain organoids are self-organized, three-dimensional (3D) aggregates derived from human embryonic stem cells, induced pluripotent stem cells, or primary organs with cell types and cellular architectures resembling those of the developing human brain ...
Aderonke O. Ajongbolo +1 more
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Brain Organoids, the Path Forward?
Voices in BioethicsPhoto by Maxim Berg on Unsplash INTRODUCTION The brain is one of the most foundational parts of being human, and we are still learning about what makes humans unique.
Ashley Diloreto
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One‐Step Drug Screening System Utilizing Electrophysiological Activity in Multiple Brain Organoids [PDF]
Advanced ScienceHuman‐induced pluripotent stem cell (iPSC)‐derived brain organoids have attracted significant attention as promising models for drug screening owing to their remarkable resemblance to the human brain.
Hyogeun Shin +9 more
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Human brain organoid code of conduct
Frontiers in Molecular Medicine, 2023 Human brain organoids are models derived from human embryonic or induced pluripotent stem cells that mimic basic cerebral microanatomy and demonstrate simple functional neuronal networks.
Meagan Hoppe +13 more
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Generation of vascularized brain organoids to study neurovascular interactions
eLife, 2022 Brain organoids have been used to recapitulate the processes of brain development and related diseases. However, the lack of vasculatures, which regulate neurogenesis and brain disorders, limits the utility of brain organoids.
Xin-Yao Sun +9 more
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Vascularization of Human Brain Organoids [PDF]
Stem Cells, 2021 Abstract Human brain organoids are three-dimensional tissues that are generated in vitro from pluripotent stem cells and recapitulate the early development of the human brain. Brain organoids consist mainly of neural lineage cells, such as neural stem/precursor cells, neurons, astrocytes, and oligodendrocytes.
Takeshi K. Matsui +3 more
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Generation of Human Blood Vessel and Vascularized Cerebral Organoids
Bio-Protocol, 2023 Brain organoids have been widely used to study diseases and the development of the nervous system. Many reports have investigated the application of brain organoids, but most of these models lack vascular structures, which play essential roles in brain ...
Xin Sun +5 more
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Human Brain Organoids and Consciousness [PDF]
Neuroethics, 2022 AbstractThis article proposes a methodological schema for engaging in a productive discussion of ethical issues regarding human brain organoids (HBOs), which are three-dimensional cortical neural tissues created using human pluripotent stem cells. Although moral consideration of HBOs significantly involves the possibility that they have consciousness ...
Takuya Niikawa +3 more
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Scientific Reports, 2022 The establishment of robust human brain organoids to model cerebellar diseases is essential to study new therapeutic strategies for cerebellum-associated disorders.
João Brás +9 more
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