Results 11 to 20 of about 23,134 (164)
Mechanics of human brain organoids [PDF]
Physical Review E, 2020 Organoids are prototypes of human organs derived from cultured human stem cells. They provide a reliable and accurate experimental model to study the physical mechanisms underlying the early developmental stages of human organs and, in particular, the early morphogenesis of the cortex.
Valentina Balbi +2 more
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Unraveling Human Brain Development and Evolution Using Organoid Models
Frontiers in Cell and Developmental Biology, 2021 Brain organoids are proving to be physiologically relevant models for studying human brain development in terms of temporal transcriptional signature recapitulation, dynamic cytoarchitectural development, and functional electrophysiological maturation ...
Sarah Fernandes +5 more
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Brain organoids are new tool for drug screening of neurological diseases
Neural Regeneration Research, 2023 At the level of in vitro drug screening, the development of a phenotypic analysis system with high-content screening at the core provides a strong platform to support high-throughput drug screening. There are few systematic reports on brain organoids, as
Jin-Qi Zhou +7 more
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Human Brain Organoids to Decode Mechanisms of Microcephaly
Frontiers in Cellular Neuroscience, 2020 Brain organoids are stem cell-based self-assembling 3D structures that recapitulate early events of human brain development. Recent improvements with patient-specific 3D brain organoids have begun to elucidate unprecedented details of the defective ...
Elke Gabriel +3 more
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Activity-induced instabilities of brain organoids [PDF]
The European Physical Journal E, 2021 AbstractWe present an analytical and numerical investigation of the activity-induced hydrodynamic instabilities in model brain organoids. While several mechanisms have been introduced to explain the experimental observation of surface instabilities in brain organoids, the role of activity has been largely overlooked.
Thijssen, Kristian +2 more
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The Application of Brain Organoids: From Neuronal Development to Neurological Diseases
Frontiers in Cell and Developmental Biology, 2020 Brain organoids are derived from induced pluripotent stem cells and embryonic stem cells under three-dimensional culture condition. The generation of an organoid requires the self-assembly of stem cells, progenitor cells, and multiple types of ...
Yikai Shou +7 more
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eLife, 2022 Fusing brain organoids with blood vessel organoids leads to the incorporation of non-neural endothelial cells and microglia into the brain organoids.
Bilal Cakir, In-Hyun Park
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Frontiers in Neuroscience, 2021 Over the past years, brain development has been investigated in rodent models, which were particularly relevant to establish the role of specific genes in this process.
Lisiane O. Porciúncula +4 more
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Genetic Modification of Brain Organoids [PDF]
Frontiers in Cellular Neuroscience, 2019 Brain organoids have become increasingly used systems allowing 3D-modeling of human brain development, evolution, and disease. To be able to make full use of these modeling systems, researchers have developed a growing toolkit of genetic modification techniques.
Fischer, J., Heide, M., Huttner, W.
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Synthetic Analyses of Single-Cell Transcriptomes from Multiple Brain Organoids and Fetal Brain
Cell Reports, 2020 Summary: Human brain organoid systems offer unprecedented opportunities to investigate both neurodevelopmental and neurological disease. Single-cell-based transcriptomics or epigenomics have dissected the cellular and molecular heterogeneity in the brain
Yoshiaki Tanaka +4 more
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