Results 21 to 30 of about 23,134 (164)
Human brain organoid networks [PDF]
, 2021 AbstractHuman brain organoids replicate much of the cellular diversity and developmental anatomy of the human brain. However, the physiological behavior of neuronal circuits within organoids remains relatively under-explored. With high-density CMOS microelectrode arrays (26,400 electrodes) and shank electrodes (960 electrodes), we probed broadband and ...
Tal Sharf +15 more
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Challenges in Modeling Human Neural Circuit Formation via Brain Organoid Technology
Frontiers in Cellular Neuroscience, 2020 Human brain organoids are three-dimensional self-organizing tissues induced from pluripotent cells that recapitulate some aspects of early development and some of the early structure of the human brain in vitro.
Takeshi K. Matsui +2 more
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Engineered extracellular matrices facilitate brain organoids from human pluripotent stem cells
Annals of Clinical and Translational Neurology, 2023 Objective Brain organoids are miniaturized in vitro brain models generated from pluripotent stem cells, which resemble full‐sized brain more closely than conventional two‐dimensional cell cultures. Although brain organoids mimic the human brain's cell‐to‐
Ayşe J. Muñiz +10 more
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Nature Communications, 2021 Brain organoids derived from human pluripotent stem cells can model human brain development and disease, though current culture systems fail to ensure reliable production of high-quality organoids.
Ann-Na Cho +22 more
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Nature Communications, 2021 3D brain organoids have been used to investigate human brain development and pathology. Here the authors establish human ventral midbrain organoids coupled with single cell sequencing to study developing and mature dopamine neurons and use silk ...
Alessandro Fiorenzano +13 more
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What Makes Organoids Good Models of Human Neurogenesis?
Frontiers in Neuroscience, 2022 Human neurogenesis occurs mainly in embryonic, fetal, and neonatal stages and generates tremendously diverse neural cell types that constitute the human nervous system.
Qian Yang +10 more
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Moral Limits of Brain Organoid Research [PDF]
Journal of Law, Medicine & Ethics, 2019 Brain organoid research raises ethical challenges not seen in other forms of stem cell research. Given that brain organoids partially recapitulate the development of the human brain, it is plausible that brain organoids could one day attain consciousness and perhaps even higher cognitive abilities.
Koplin, JJ, Savulescu, J
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Human 3D brain organoids: steering the demolecularization of brain and neurological diseases
Cell Death Discovery, 2023 Understanding of human brain development, dysfunction and neurological diseases has remained limited and challenging due to inability to recapitulate human brain-specific features in animal models. Though the anatomy and physiology of the human brain has
Yogita K. Adlakha
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Advances and Applications of Brain Organoids
Neuroscience Bulletin, 2023 AbstractUnderstanding the fundamental processes of human brain development and diseases is of great importance for our health. However, existing research models such as non-human primate and mouse models remain limited due to their developmental discrepancies compared with humans.
Yang Li +3 more
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3D-printed microplate inserts for long term high-resolution imaging of live brain organoids
BMC Biomedical Engineering, 2021 Background Organoids are a reliable model used in the study of human brain development and under pathological conditions. However, current methods for brain organoid culture generate tissues that range from 0.5 to 2 mm of size, which need to be ...
Mariana Oksdath Mansilla +17 more
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