Results 31 to 40 of about 23,134 (164)

3D organotypic cell structures for drug development and Microorganism-Host interaction research [PDF]

Research Results in Pharmacology, 2021
Introduction: The article describes a new method of tissue engineering, which is based on the use of three-dimensional multicellular constructs consisting of stem cells that mimic the native tissue in vivo – organoids.
Ekaterina V. Zubareva, Sergey V. Nadezhdin, Natalia A. Nadezhdina, Veronika S. Belyaeva, Yuriy E. Burda, Tatyana V. Avtina, Oleg S. Gudyrev, Inga M. Kolesnik, Svetlana Yu. Kulikova, Mikhail O. Mishenin   +9 more
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Modeling human neurodevelopmental diseases with brain organoids

Cell Regeneration, 2022
Studying the etiology of human neurodevelopmental diseases has long been a challenging task due to the brain’s complexity and its limited accessibility.
Xiaoxiang Lu, Jiajie Yang, Yangfei Xiang
doaj   +1 more source

Human Brain Organoids as an In Vitro Model System of Viral Infectious Diseases

Frontiers in Immunology, 2022
Brain organoids, or brainoids, have shown great promise in the study of central nervous system (CNS) infection. Modeling Zika virus (ZIKV) infection in brain organoids may help elucidate the relationship between ZIKV infection and microcephaly.
Xuan Su, Xuan Su, Peng Yue, Peng Yue, Jing Kong, Jing Kong, Xin Xu, Xin Xu, Yu Zhang, Yu Zhang, Wenjing Cao, Wenjing Cao, Yuxin Fan, Yuxin Fan, Meixiao Liu, Meixiao Liu, Jingjing Chen, Jingjing Chen, Aihua Liu, Aihua Liu, Fukai Bao, Fukai Bao   +21 more
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Modeling neurological disorders using brain organoids

Seminars in Cell & Developmental Biology, 2021
Neurological disorders are challenging to study given the complexity and species-specific features of the organ system. Brain organoids are three dimensional structured aggregates of neural tissue that are generated by self-organization and differentiation from pluripotent stem cells under optimized culture conditions.
Daniel Y, Zhang, Hongjun, Song, Guo-Li, Ming   +2 more
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Emerging brain organoids: 3D models to decipher, identify and revolutionize brain

Bioactive Materials
Brain organoids are an emerging in vitro 3D brain model that is integrated from pluripotent stem cells. This model mimics the human brain’s developmental process and disease-related phenotypes to a certain extent while advancing the development of human ...
Yuli Zhao, Ting Wang, Jiajun Liu, Ze Wang, Yuan Lu   +4 more
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Telencephalic organoids as model systems to study cortical development and diseases [PDF]

Organoid
The telencephalon is the largest region of the brain and processes critical brain activity. Despite much progress, our understanding of the telencephalon’s function, development, and pathophysiological processes remains largely incomplete.
Woo Sub Yang, Ferdi Ridvan Kiral, In-Hyun Park   +2 more
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Electrophysiological Analysis of Brain Organoids: Current Approaches and Advancements

Frontiers in Neuroscience, 2021
Brain organoids, or cerebral organoids, have become widely used to study the human brain in vitro. As pluripotent stem cell-derived structures capable of self-organization and recapitulation of physiological cell types and architecture, brain organoids ...
Austin P. Passaro, Austin P. Passaro, Steven L. Stice, Steven L. Stice, Steven L. Stice   +4 more
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From Brain Organoids to Networking Assembloids: Implications for Neuroendocrinology and Stress Medicine

Frontiers in Physiology, 2021
Brain organoids are three-dimensional cultures that contain multiple types of cells and cytoarchitectures, and resemble fetal human brain structurally and functionally. These organoids are being used increasingly to model brain development and disorders,
Evanthia A. Makrygianni, George P. Chrousos, George P. Chrousos   +2 more
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Translational potential of human brain organoids [PDF]

Annals of Clinical and Translational Neurology, 2018
Abstract The recent technology of 3D cultures of cellular aggregates derived from human stem cells have led to the emergence of tissue‐like structures of various organs including the brain. Brain organoids bear molecular and structural resemblance with developing human brains, and have been demonstrated to recapitulate several ...
Sun A.X., Ng H.-H., Tan E.-K.
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Brain Organoids to Evaluate Cellular Therapies

Animals, 2022
Animal models currently used to test the efficacy and safety of cell therapies, mainly murine models, have limitations as molecular, cellular, and physiological mechanisms are often inherently different between species, especially in the brain. Therefore, for clinical translation of cell-based medicinal products, the development of alternative models ...
Ana Belén García-Delgado, Rafael Campos-Cuerva, Cristina Rosell-Valle, María Martin-López, Carlos Casado, Daniela Ferrari, Javier Márquez-Rivas, Rosario Sánchez-Pernaute, Beatriz Fernández-Muñoz   +8 more
openaire   +8 more sources