Results 41 to 50 of about 23,134 (164)
Cell Regeneration, 2022 Early human brain development can be affected by multiple prenatal factors that involve chemical exposures in utero, maternal health characteristics such as psychiatric disorders, and cancer.
Kangli Cui +7 more
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Rapid and Efficient Generation of Myelinating Human Oligodendrocytes in Organoids
Frontiers in Cellular Neuroscience, 2021 Human stem cell derived brain organoids are increasingly gaining attention as an ideal model system for investigating neurological diseases, particularly those that involve myelination defects.
Mohammed R. Shaker +6 more
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Brain organoid data synthesis and evaluation
Frontiers in Neuroscience, 2023 IntroductionDatasets containing only few images are common in the biomedical field. This poses a global challenge for the development of robust deep-learning analysis tools, which require a large number of images. Generative Adversarial Networks (GANs) are an increasingly used solution to expand small datasets, specifically in the biomedical domain ...
Clara Brémond-Martin +4 more
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Modeling APOE ε4 familial Alzheimer’s disease in directly converted 3D brain organoids
Frontiers in Aging NeuroscienceBrain organoids have become a valuable tool for studying human brain development, disease modeling, and drug testing. However, generating brain organoids with mature neurons is time-intensive and often incomplete, limiting their utility in studying age ...
Yunkyung Kim +7 more
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Modelling Toxoplasma gondii infection in human cerebral organoids
Emerging Microbes and Infections, 2020 Pluripotent stem cell-derived cerebral organoids have the potential to recapitulate the pathophysiology of in vivo human brain tissue, constituting a valuable resource for modelling brain disorders, including infectious diseases.
Hyang-Hee Seo +7 more
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Vascularized human brain organoid on-chip
Lab on a Chip, 2023 We review the existingin vitrohuman brain models and elaborate on various strategies that enable the curation of a vascularized human brain organoid using microfluidic devices.
Sin Yen Tan +3 more
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Functional neuronal circuitry and oscillatory dynamics in human brain organoids
Nature Communications, 2022 Brain organoids replicate cellular organization found in the developing human brain. Here, the authors utilize microelectronics to map activity in brain organoids and assemble functional circuits that mirror complexity found in brain networks in vivo.
Tal Sharf +15 more
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Cell Stem Cell, 2018 In large mammalian brains, including those of humans, the surface of the cortex is highly folded. How these convolutions form is still unclear, but recent work in Nature Physics by Karzbrun et al. (2018) supports a mechanism involving differential surface swelling combined with internal constraint.
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Cerebral Organoids Recapitulate Epigenomic Signatures of the Human Fetal Brain
Cell Reports, 2016 Organoids derived from human pluripotent stem cells recapitulate the early three-dimensional organization of the human brain, but whether they establish the epigenomic and transcriptional programs essential for brain development is unknown.
Chongyuan Luo +5 more
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Efficient generation of brain organoids using magnetized gold nanoparticles
Scientific Reports, 2023 Brain organoids, which are three-dimensional cell culture models, have the ability to mimic certain structural and functional aspects of the human brain.
Hongwon Kim +3 more
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