Results 51 to 60 of about 23,134 (164)

Generation of human vascularized brain organoids [PDF]

NeuroReport, 2018
The aim of this study was to vascularize brain organoids with a patient's own endothelial cells (ECs). Induced pluripotent stem cells (iPSCs) of one UC Davis patient were grown into whole-brain organoids. Simultaneously, iPSCs from the same patient were differentiated into ECs.
Pham, Missy T, Pollock, Kari M, Rose, Melanie D, Cary, Whitney A, Stewart, Heather R, Zhou, Ping, Nolta, Jan A, Waldau, Ben   +7 more
openaire   +4 more sources

Reliability of high-quantity human brain organoids for modeling microcephaly, glioma invasion and drug screening

Nature Communications
Brain organoids offer unprecedented insights into brain development and disease modeling and hold promise for drug screening. Significant hindrances, however, are morphological and cellular heterogeneity, inter-organoid size differences, cellular stress,
Anand Ramani, Giovanni Pasquini, Niklas J. Gerkau, Vaibhav Jadhav, Omkar Suhas Vinchure, Nazlican Altinisik, Hannes Windoffer, Sarah Muller, Ina Rothenaigner, Sean Lin, Aruljothi Mariappan, Dhanasekaran Rathinam, Ali Mirsaidi, Olivier Goureau, Lucia Ricci-Vitiani, Quintino Giorgio D’Alessandris, Bernd Wollnik, Alysson Muotri, Limor Freifeld, Nathalie Jurisch-Yaksi, Roberto Pallini, Christine R. Rose, Volker Busskamp, Elke Gabriel, Kamyar Hadian, Jay Gopalakrishnan   +25 more
doaj   +1 more source

Cerebral Malaria Model Applying Human Brain Organoids

Cells, 2023
Neural injuries in cerebral malaria patients are a significant cause of morbidity and mortality. Nevertheless, a comprehensive research approach to study this issue is lacking, so herein we propose an in vitro system to study human cerebral malaria using cellular approaches.
Rita Silva-Pedrosa, Jonas Campos, Aline Marie Fernandes, Miguel Silva, Carla Calçada, Ana Marote, Olga Martinho, Maria Isabel Veiga, Ligia R. Rodrigues, António José Salgado, Pedro Eduardo Ferreira   +10 more
openaire   +4 more sources

A tumorigenicity evaluation platform for cell therapies based on brain organoids

Translational Neurodegeneration
Background Tumorigenicity represents a critical challenge in stem cell-based therapies requiring rigorous monitoring. Conventional approaches for tumorigenicity evaluation are based on animal models and have numerous limitations.
Jun Xue, Youjun Chu, Yanwang Huang, Ming Chen, Meng Sun, Zhiqin Fan, Yonghe Wu, Liang Chen   +7 more
doaj   +1 more source

Brain organoid protocols and limitations

Frontiers in Cellular Neuroscience
Stem cell-derived organoid technology is a powerful tool that revolutionizes the field of biomedical research and extends the scope of our understanding of human biology and diseases. Brain organoids especially open an opportunity for human brain research and modeling many human neurological diseases, which have lagged due to the inaccessibility of ...
Helen H. Zhao, Gabriel Haddad, Gabriel Haddad, Gabriel Haddad   +3 more
openaire   +5 more sources

Approaches to vascularizing human brain organoids

PLOS Biology, 2023
A major challenge in brain organoid technologies is the lack of vasculature. In recent years, innovative approaches have been taken to meet this challenge. A 2020 paper published in PLOS Biology exemplifies the approaches used in this booming field.
openaire   +3 more sources

Analysis of Synapses in Cerebral Organoids

Cell Transplantation, 2019
Cerebral organoids are an emerging cutting-edge technology to model human brain development and neurodevelopmental disorders, for which mouse models exhibit significant limitations.
Abraam M. Yakoub, Mark Sadek
doaj   +1 more source

Cerebral organoids exhibit mature neurons and astrocytes and recapitulate electrophysiological activity of the human brain

Neural Regeneration Research, 2019
Multiple protocols have been devised to generate cerebral organoids that recapitulate features of the developing human brain, including the presence of a large, multi-layered, cortical-like neuronal zone.
Abraam M Yakoub
doaj   +1 more source

Human brain organoid: trends, evolution, and remaining challenges

Neural Regeneration Research
Advanced brain organoids provide promising platforms for deciphering the cellular and molecular processes of human neural development and diseases. Although various studies and reviews have described developments and advancements in brain organoids, few ...
Minghui Li, Yuhan Yuan, Zongkun Hou, Shilei Hao, Liang Jin, Bochu Wang   +5 more
doaj   +1 more source

Vascularizing the brain organoids

Journal of Molecular Cell Biology, 2022
Xin-Yao Sun, Zhen-Ge Luo
openaire   +2 more sources