Results 61 to 70 of about 23,134 (164)
Biochemistry and Biophysics ReportsHere, the protective mechanism of Codonopsis pilosula polysaccharide (CpP) against mouse brain organoids (mBO) damage was analyzed, and the rotenone affected the genomic epigenetic modifications and physiological activity of mouse brain organoids was ...
Haiyang Chen +5 more
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Brain organoids: advances, applications and challenges
Development, 2019 ABSTRACT Brain organoids are self-assembled three-dimensional aggregates generated from pluripotent stem cells with cell types and cytoarchitectures that resemble the embryonic human brain. As such, they have emerged as novel model systems that can be used to investigate human brain development and disorders.
Xuyu Qian, Hongjun Song, Guo-li Ming
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Cerebral organoid research for pediatric patients with neurological disorders [PDF]
Clinical and Experimental PediatricsCerebral organoids derived from human induced pluripotent stem cells offer a groundbreaking foundation for the analysis of pediatric neurological diseases. Unlike organoids from other somatic systems, cerebral organoids present unique challenges, such as
Jin Eun, Jung Eun Lee, Seung Ho Yang
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Brain organoids and Ó?organoid intelligenceÓ�: a neuroethical critique
Bioethics UpdateBackground: The article “Brain organoids and ‘organoid intelligence’” delves into the cutting-edge research surrounding the cultivation and utilization of brain organoids. It highlights the potential of these miniaturized, simplified versions of the brain to revolutionize our understanding of neural development, disease mechanisms, and neurophysiology.
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The Ethical Paradoxes of Human Cerebral Organoids Technology and Their Solutions
Yixue yu zhexueHuman brain organoids are used to study the developmental mechanisms of the human brain, brain diseases, and more. However, the more advanced the human cerebral organoids are, the intenser the ethical debates it provokes are.
Bin HUANG, Xiang HOU
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Modeling Neurological Diseases With Human Brain Organoids
Frontiers in Synaptic Neuroscience, 2018 The complexity and delicacy of human brain make it challenging to recapitulate its development, function and disorders. Brain organoids derived from human pluripotent stem cells (PSCs) provide a new tool to model both normal and pathological human brain,
Hansen Wang
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Scientific ReportsBiallelic loss-of-function variants of Seizure Threshold 2 (SZT2) cause neurodevelopmental diseases with developmental delay, epilepsy, and macrocephaly.
Emi Sato +9 more
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Bioengineering & Translational MedicineSelf‐organizing brain organoids provide a promising tool for studying human development and disease. Here we created human forebrain organoids with stable and homogeneous expression of channelrhodopsin‐2 (ChR2) by generating AAVS1 safe harbor locus ...
Soojung Hong +4 more
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Neural Regeneration ResearchThe brain is the most complex human organ, and commonly used models, such as two-dimensional-cell cultures and animal brains, often lack the sophistication needed to accurately use in research.
Raquel Coronel +10 more
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Brain organoid maturation and implantation integration based on electrical signals input
Journal of Advanced ResearchIntroduction: Brain organoids are believed to be able to regenerate impaired neural circuits and reinstate brain functionality. The neuronal activity of organoids is considered a crucial factor for restoring host function after implantation. However, the
Xiao-Hong Li +11 more
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