Results 111 to 120 of about 1,850,852 (293)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Influence factors in increasing brand loyalty through customer engagement on MPV cars
JPPI (Jurnal Penelitian Pendidikan Indonesia)Customer engagement can be formed with supportive social media marketing and brand experience. But in this case, the company has not fully created the experience and social media consumers need.
Indawati Lestari +2 more
doaj +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Brand Guidelines: International Rice Research Institute
These guidelines help ensure that every initiative and activity of the International Rice Research Institute presents one clear and consistent brand. By following them, IRRI staff and external partners strengthen IRRI’s identity, enhance recognition, and
IRRI Communication and Engagement Department
core
Journal of Engineering, Project, and Production ManagementWithin a strategic management framework, this study investigated the mediating roles of customer engagement and brand awareness in the relationship between content marketing and purchase intentions in Egypt’s beauty sector.
Atef Fakhfakh +4 more
doaj +1 more source
Age 2.0: motivations and brand engagement
, 2020 The demographic winter that is widespread throughout Europe, along with the spread of network society, has brought to contemporary societies a striking new world of opportunity and challenge. The increasing adhesion of seniors to the Information and Communication Technologies and, in particular, to digital social networks while being seen as a positive
Miranda, Sandra +3 more
openaire +2 more sources
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Antecedents of consumer-brand engagement: The mediating role of brand satisfaction
South African Journal of Economic and Management SciencesBackground: Customer management has evolved from transaction-based to customer engagement, emphasising the importance of establishing strong customer-brand relationships.
Thinkwell Ndhlovu, Tania Maree
doaj +1 more source