Results 221 to 230 of about 493,088 (328)
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Platform power, athlete branding, generative AI, and the future of sport governance-a systematic review. [PDF]
Westerbeek H, van Schaik T.
europepmc +1 more source
Effect of Brand Identity and Brand Image On Customer Loyalty Case Study In Daihatsu Car Consumer
Catur Rachmad Susetyo +2 more
openalex +2 more sources
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
From function to wellbeing: healing design strategies in contemporary outdoor fashion. [PDF]
Li Y, Kam S.
europepmc +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Enhanced fuzzy combined techniques for group decision-making with 2-tuple linguistic neutrosophic number and applications to sports event brand building evaluation. [PDF]
Lian J, Guo H, Hwan CK, Meng Y.
europepmc +1 more source
A Study on the Brand Identity Platform Development for Capital of Culture
HoSeung Yang, EunSil Yi
openalex +1 more source
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source

