UPR-induced intracellular C5aR1 promotes adaptation to the hypoxic tumour microenvironment [PDF]
Cell Death and DiseaseDysregulation of the C5a-C5a receptor 1 (C5aR1) signalling axis underlies inflammation and immune-driven pathology. C5aR1 was traditionally thought to be primarily expressed on the cell membrane, although recent reports indicate the importance of ...
Tatsuya Suwa +10 more
doaj +4 more sources
Evaluating the usefulness of C5 and C5AR1 as genetic biomarkers of IgA-mediated vasculitis [PDF]
Molecular MedicineBackground IgA-mediated vasculitis (IgAV) is a complex inflammatory disease. Unravelling its genetic background would allow us to identify genetic biomarkers that may be used as additional tools in its daily management, helping to solve the clinical ...
Joao Carlos Batista-Liz +23 more
doaj +3 more sources
13-methylpalmatine alleviates myocardial ischemia/reperfusion injury by potentially targeting the C5a-C5aR1 axis to inhibit neutrophil extracellular trap formation [PDF]
Redox BiologyThe complement system activation-induced inflammation is a critical contributor to myocardial ischemia/reperfusion (I/R) injury. However, effective therapeutic targets and pharmacological interventions remain limited.
Miao Zhang +14 more
doaj +3 more sources
C5aR1 Inhibition Alleviates Cranial Radiation-Induced Cognitive Decline. [PDF]
Cancer ResCranial radiation therapy (RT) for brain cancers leads to an irreversible decline in cognitive function without an available remedy. Radiation-induced cognitive decline (RICD) is a particularly pressing problem for brain cancer survivors who live long ...
Krattli RP +12 more
europepmc +3 more sources
Inhibition of C5a-C5aR1 axis suppresses tumour progression by enhancing antitumour immunity and chemotherapeutic effect in pancreatic ductal adenocarcinoma. [PDF]
Br J CancerComplement factors regulate tumour immunity in the tumour microenvironment (TME). We investigated the functions of complement 5a (C5a) and its receptors, C5aR1 and C5aR2, in forming the C5a-C5aR1 and C5a-C5aR2 signaling axes in the immune TME of ...
Eto R +7 more
europepmc +2 more sources
Regulation of phosphatase and tensin homolog by complement component 5a (C5a) and its receptor (C5aR1) in lupus nephritis: A novel therapeutic target. [PDF]
J Cell Commun SignalLupus nephritis (LN), a renal manifestation of systemic lupus erythematosus, results from immune‐mediated kidney injury. The present study investigated how complement component 5a (C5a) and its receptor (C5aR1) regulate phosphatase and tensin homolog ...
Ma Y +6 more
europepmc +2 more sources
Bioinformatics analysis reveals C5AR1's impact on thyroid cancer development via immune infiltration. [PDF]
Sci RepThyroid cancer (THCA) remains a prevalent endocrine malignancy, with limited molecular markers for accurate diagnosis and targeted therapy. This study aimed to identify key biomarkers and therapeutic targets for THCA using integrative bioinformatics and ...
Sun Y +9 more
europepmc +2 more sources
The Pleiotropic Effect of Complement C5a-C5aR1 Pathway in Diseases: From Immune Regulation to Targeted Therapy. [PDF]
Int J Mol SciThe complement system plays a pivotal role in the body’s immune defense mechanism. Its key effector molecule C5a and its primary receptor C5aR1 exhibit complex “double-edged sword” effects in various disease processes, including infectious diseases ...
Xu B +6 more
europepmc +2 more sources
Cell Death and DiseaseGlioblastoma (GBM) is the most common primary intracranial malignant tumor. Recent literature suggests that induction of programmed death has become a mainstream cancer treatment strategy, with ferroptosis being the most widely studied mode.
Xiangrui Meng +9 more
doaj +2 more sources
Nature CommunicationsAlzheimer’s disease (AD) is the leading cause of dementia in older adults, and the need for effective, sustainable therapeutic targets is imperative. The complement pathway has been proposed as a therapeutic target.
Nicole D. Schartz +8 more
doaj +2 more sources