Results 11 to 20 of about 7,153 (219)

Osteoblast-specific overexpression of complement receptor C5aR1 impairs fracture healing. [PDF]

PLoS ONE, 2017
The anaphylatoxin receptor C5aR1 plays an important role not only in innate immune responses, but also in bone metabolism and fracture healing, being highly expressed on immune and bone cells, including osteoblasts and osteoclasts.
Stephanie Bergdolt, Anna Kovtun, Yvonne Hägele, Astrid Liedert, Thorsten Schinke, Michael Amling, Markus Huber-Lang, Anita Ignatius   +7 more
doaj   +4 more sources

C5aR1 signaling triggers lung immunopathology in COVID-19 through neutrophil extracellular traps

The Journal of Clinical Investigation, 2023
Patients with severe COVID-19 develop acute respiratory distress syndrome (ARDS) that may progress to cytokine storm syndrome, organ dysfunction, and death.
Bruna M. Silva, Giovanni F. Gomes, Flavio P. Veras, Seppe Cambier, Gabriel V.L. Silva, Andreza U. Quadros, Diego B. Caetité, Daniele C. Nascimento, Camilla M. Silva, Juliana C. Silva, Samara Damasceno, Ayda H. Schneider, Fabio Beretta, Sabrina S. Batah, Icaro M.S. Castro, Isadora M. Paiva, Tamara Rodrigues, Ana Salina, Ronaldo Martins, Guilherme C.M. Cebinelli, Naira L. Bibo, Daniel M. Jorge, Helder I. Nakaya, Dario S. Zamboni, Luiz O. Leiria, Alexandre T. Fabro, José C. Alves-Filho, Eurico Arruda, Paulo Louzada-Junior, Renê D. Oliveira, Larissa D. Cunha, Pierre Van Mol, Lore Vanderbeke, Simon Feys, Els Wauters, Laura Brandolini, Andrea Aramini, Fernando Q. Cunha, Jörg Köhl, Marcello Allegretti, Diether Lambrechts, Joost Wauters, Paul Proost, Thiago M. Cunha   +43 more
doaj   +4 more sources

Mechanism of activation and biased signaling in complement receptor C5aR1

Cell Research, 2023
The complement system plays an important role in the innate immune response to invading pathogens. The complement fragment C5a is one of its important effector components and exerts diverse physiological functions through activation of the C5a receptor 1
Yuying Feng, Chang Zhao, Yue Deng, Heli Wang, Liang Ma, Si-Yue Liu, Xiaowen Tian, Bo Wang, Yan Bin, Peipei Chen, Wei Yan, P. Fu, Zhenhua Shao   +12 more
semanticscholar   +3 more sources

ACSL4 Drives C5a/C5aR1-Calcium-Induced Fibroblast-to-Myofibroblast Transition in a Bleomycin-Induced Mouse Model of Pulmonary Fibrosis. [PDF]

Biomolecules
Idiopathic pulmonary fibrosis (IPF) is characterized by excessive extracellular matrix (ECM) deposition driven by aberrant fibroblast-to-myofibroblast transition (FMT).
Ren T, Shi J, Zhuang L, Su R, Lai Y, Yang N.   +5 more
europepmc   +2 more sources

C5a/C5aR1 Pathway Is Critical for the Pathogenesis of Psoriasis [PDF]

Frontiers in Immunology, 2019
Psoriasis is one of the most common chronic inflammatory skin diseases, affecting ~2% of the population. The lack of characterization of the pathogenesis of psoriasis has hindered efficient clinical treatment of the disease.
Quan-you Zheng, Quan-you Zheng, Shen-ju Liang, Feng Xu, Gui-qing Li, Na Luo, Shun Wu, You Li, Ming Tang, Yu Zhong, Jian Chen, Di Yang, Dao-dong Sun, Ke-qin Zhang, Gui-lian Xu   +14 more
doaj   +7 more sources

Modulation of C5a–C5aR1 signaling alters the dynamics of AD progression [PDF]

Journal of Neuroinflammation, 2022
Background The complement system is part of the innate immune system that clears pathogens and cellular debris. In the healthy brain, complement influences neurodevelopment and neurogenesis, synaptic pruning, clearance of neuronal blebs, recruitment of ...
Klebea Carvalho, Nicole D. Schartz, Gabriela Balderrama-Gutierrez, Heidi Y. Liang, Shu-Hui Chu, Purnika Selvan, Angela Gomez-Arboledas, Tiffany J. Petrisko, Maria I. Fonseca, Ali Mortazavi, Andrea J. Tenner   +10 more
doaj   +4 more sources

C5a-C5aR1 axis mediates lung inflammation and fibrosis induced by single-walled carbon nanotubes via promoting neutrophils recruitment

Ecotoxicology and Environmental Safety
A mounting number of studies have been documenting strong pro-inflammatory and pro-fibrotic effects of carbon nanotube (CNT). However, the molecular mechanisms of single-walled CNT (SWCNT)-provoked lung injury remain to be elucidated.
Jiaojiao Zhu, Xiang Zhang, Lanlan Li, Hongxu Yang, Hang Liu, Danyang Wu, Zikai Liu, Bin Liu, Tong Shen   +8 more
doaj   +2 more sources

Blockade of C5aR1 resets M1 via gut microbiota-mediated PFKM stabilization in a TLR5-dependent manner

Cell Death and Disease
Targeting C5aR1 modulates the function of infiltrated immune cells including tumor-associated macrophages (TAMs). The gut microbiome plays a pivotal role in colorectal cancer (CRC) tumorigenesis and development through TAM education. However, whether and
Jie Zhao, Chen Yao, Yongqin Qin, Hanyong Zhu, Hui Guo, Binbin Ji, Xueqin Li, Na Sun, Rongqing Li, Yuzhang Wu, Kuiyang Zheng, Yuchen Pan, Tingting Zhao, Jing Yang   +13 more
doaj   +2 more sources

Association of COVID-19 inflammation with activation of the C5a-C5aR1 axis [PDF]

Nature, 2020
Coronavirus disease 2019 (COVID-19) is a disease caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has resulted in a pandemic1.
Julien Carvelli, O. Demaria, F. Vely, L. Batista, N. Benmansour, J. Fares, S. Carpentier, Marie‐Laure Thibult, Ariane Morel, R. Remark, P. André, Agnès Represa, C. Pipéroglou, P. Cordier, Erwan Le Dault, C. Guervilly, P. Simeone, M. Gainnier, Y. Morel, M. Ebbo, N. Schleinitz, É. Vivier   +21 more
semanticscholar   +3 more sources

C5a–C5AR1 axis as a potential trigger of the rupture of intracranial aneurysms

Scientific Reports
Recent studies have indicated the involvement of neutrophil-mediated inflammatory responses in the process leading to intracranial aneurysm (IA) rupture. Receptors mediating neutrophil recruitment could thus be therapeutic targets of unruptured IAs.
Akihiro Okada, Kampei Shimizu, Akitsugu Kawashima, Tomomichi Kayahara, Masahiko Itani, Hiroki Kurita, Susumu Miyamoto, Hiroharu Kataoka, Tomohiro Aoki   +8 more
doaj   +2 more sources