Results 21 to 30 of about 7,153 (219)

C5aR2 Deficiency Lessens C5aR1 Distribution and Expression in Neutrophils and Macrophages

Journal of Immunology Research
As another receptor for complement activation product C5a, C5aR2 has been paid much attention these years. Although controversial and complex, its specific signals or roles in modulating the classic receptor C5aR1 have been investigated and gradually ...
Ting Zhang, Ning Ma, Jiaxing Wang, Xiaoyun Min, Linlin Wei, Ke Li   +5 more
doaj   +3 more sources

<i>Adu</i>CPI2 alleviates MSU-induced acute gouty arthritis in mice by inhibiting cathepsin S and the C5a-C5aR1 axis. [PDF]

Front Pharmacol
Background Gout, a prevalent and severe form of arthritis precipitated by hyperuricemia, has been the subject of extensive research. However, the intricate underlying mechanisms governing gout-related inflammation are still only partially elucidated ...
Liu S, Situ Y, Deng L, Liang M, He H, Shao Z, Peng L.   +6 more
europepmc   +2 more sources

Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1

The Journal of Clinical Investigation, 2023
An immunosuppressive microenvironment causes poor tumor T cell infiltration and is associated with reduced patient overall survival in colorectal cancer. How to improve treatment responses in these tumors is still a challenge.
Callum Beach, David MacLean, Dominika Majorova, Stavros Melemenidis, Dhanya K. Nambiar, Ryan K. Kim, Gabriel N. Valbuena, Silvia Guglietta, Carsten Krieg, Mahnaz Darvish-Damavandi, Tatsuya Suwa, Alistair Easton, Lily V.S. Hillson, Ashley K. McCulloch, Ross K. McMahon, Kathryn Pennel, Joanne Edwards, Sean M. O’Cathail, Campbell S. Roxburgh, Enric Domingo, Eui Jung Moon, Dadi Jiang, Yanyan Jiang, Qingyang Zhang, Albert C. Koong, Trent M. Woodruff, Edward E. Graves, Tim Maughan, Simon J.A. Buczacki, Manuel Stucki, Quynh-Thu Le, Simon J. Leedham, Amato J. Giaccia, Monica M. Olcina   +33 more
doaj   +5 more sources

Yuye Jinhua Qingre Tablets Attenuate Acute Pharyngitis by inhibiting the Complement Cascade and C5a/C5aR1 Axis. [PDF]

Chin Med
Acute pharyngitis (AP) is a common upper respiratory tract infection, primarily characterized by symptoms such as throat pain, redness, swelling, and difficulty swallowing. It is typically caused by viral infections, bacterial infections, or physical and
Gao Y, You L, Zhou J, Tao X, Jin Z, Wu C, Zhang F, Guo S, Wang H, Guan Y, Luo H, Wu J.   +11 more
europepmc   +2 more sources

C5aR1-positive adipocytes mediate non-shivering thermogenesis in neonatal mice

iScience
Summary: Brown adipose tissue (BAT) plays an important role in maintaining body temperature in newborn mammals; however, its mechanisms remain poorly understood.
Huan-Yu Wang, Xue-Min Peng, Min Yang, Ying Weng, Xi Yang, Di Zhan, Qin Ning, Xiao-Ping Luo, Yong Chen   +8 more
doaj   +3 more sources

The role of C5aR1-mediated hepatic macrophage efferocytosis in NASH

Scientific Reports
Non-alcoholic fatty liver disease (NAFLD) has become the first major chronic liver disease in developed countries. 10–20% of NAFLD patients will progress to non-alcoholic steatohepatitis (NASH), and up to 25% of NASH patients may develop cirrhosis within
Xuan Shen, Wenxing Zheng, Xinna Du, Yuping Chen, Xianping Song, Liucai Yang, Qi Yuan   +6 more
semanticscholar   +4 more sources

Conformational variants of the ternary complex of C5a, C5aR1, and G-protein

Journal of Biomolecular Structure and Dynamics
The complement component fragment 5a (C5a) binds and activates two complement receptors like C5aR1 and C5aR2, which play a significant role in orchestrating the proinflammatory function of C5a in tissues through the recruitment of heterotrimeric G ...
Pulkit Kr. Gupta, Aditi Singh, Soumendra Rana   +2 more
semanticscholar   +3 more sources

Innate Immune Cell Infiltration Induced by Polatuzumab Vedotin Contributes to the Antitumor Effect in Mouse Models. [PDF]

EJHaem
ABSTRACT Introduction Polatuzumab vedotin (Pola) is an antibody‐drug conjugate approved for the treatment of diffuse large B‐cell lymphoma (DLBCL). Several reports suggest that the tumor microenvironment influences the outcome of DLBCL treatments; with Pola, however, the link between tumor microenvironment and treatment outcome remains unclear ...
Tomita M, Kawasaki N, Yorozu K, Shu S, Kato C, Kurasawa M, Masutani B, Sax N, Yamashita-Kashima Y, Yoshiura S.   +9 more
europepmc   +2 more sources

Role of C5aR1 and C5L2 Receptors in Ischemia-Reperfusion Injury [PDF]

Journal of Clinical Medicine, 2021
The role of C5a receptors (C5aR1 and C5L2) in renal ischemia-reperfusion injury (IRI) is uncertain. We generated an in vitro model of hypoxia/reoxygenation with human proximal tubule epithelial cells to mimic some IRI events. C5aR1, membrane attack complex (MAC) and factor H (FH) deposits were evaluated with immunofluorescence.
Carlos Arias-Cabrales, Eva Rodriguez-Garcia, Javier Gimeno, David Benito, María José Pérez-Sáez, Dolores Redondo-Pachón, Anna Buxeda, Carla Burballa, Marta Crespo, Marta Riera, Julio Pascual   +10 more
openaire   +2 more sources

C5a/C5aR1 mediates the IMQ-induced psoriatic skin inflammation via promoting IL-17A expression by γδ T cells in mice [PDF]

Jichu yixue yu linchuang, 2022
Objective To explore the effects and underlying mechanism of C5a/C5aR1 pathway in mediating imiquimod (IMQ)-induced psoriatic skin inflammation by increasing IL-17A expression in γδ T cells.
ZHENG Quan-you, LIANG Shen-ju,SHU Yong, ZHOU Shan, ZHONG Yu, SHENG Fen, TANG Ming-jun
doaj   +1 more source