Results 31 to 40 of about 7,153 (219)

The activation of complement C5a-C5aR1 axis in astrocytes facilitates the neuropathogenesis due to EV-A71 infection by upregulating CXCL1

Journal of Virology
Enterovirus A71 (EV-A71) is a common small RNA virus that is highly neuroinvasive. Emerging evidence indicates that the complement fragment C5a and its receptor C5aR1 are important drivers of neuroinflammation.
Peiyu Zhu, Wangquan Ji, Dong Li, Fang Wang, Tiantian Sun, Haiyan Yang, Shuaiyin Chen, Weiguo Zhang, Yuefei Jin, Guangcai Duan   +9 more
doaj   +2 more sources

Specific inhibition of complement activation significantly ameliorates autoimmune blistering disease in mice [PDF]

, 2018
Epidermolysis bullosa acquisita (EBA) is an antibody-mediated blistering skin disease associated with tissue-bound and circulating autoantibodies to type VII collagen (COL7).
B. Paul Morgan, Detlef Zillikens, Falk Nimmerjahn, Joshua M. Thurman, Jörg Köhl, Jörg Köhl, Misa Hirose, Ralf J. Ludwig, Sidonia Mihai, Sidonia Mihai, V. Michael Holers, Yi Wang   +11 more
core   +15 more sources

Functional Analysis of a Novel Complement C5a Receptor 1-Blocking Monoclonal Antibody

Journal of Innate Immunity, 2023
Introduction: The complement system anaphylatoxin C5a is a critical player in inflammation. By binding to complement C5a receptor 1 (C5aR1/CD88), C5a regulates many cellular functions, mainly as a potent pro-inflammatory inducer.
Leon Cyranka, Ida Mariegaard, Mikkel-Ole Skjødt, Rafael Bayarri-Olmos, Tom Eirik Mollnes, Peter Garred, Anne Rosbjerg   +6 more
doaj   +1 more source

Correction: The role of C5aR1-mediated hepatic macrophage efferocytosis in NASH. [PDF]

Sci Rep
Shen X, Zheng W, Du X, Chen Y, Song X, Yang L, Yuan Q.   +6 more
europepmc   +2 more sources

The C5a/C5aR1 axis controls the development of experimental allergic asthma independent of LysM-expressing pulmonary immune cells. [PDF]

PLoS ONE, 2017
C5a regulates the development of maladaptive immune responses in allergic asthma mainly through the activation of C5a receptor 1 (C5aR1). Yet, the cell types and the mechanisms underlying this regulation are ill-defined.
Anna V Wiese, Fanny Ender, Katharina M Quell, Konstantina Antoniou, Tillman Vollbrandt, Peter König, Jörg Köhl, Yves Laumonnier   +7 more
doaj   +1 more source

Monitoring and Cell-Specific Deletion of C5aR1 Using a Novel Floxed GFP-C5aR1 Reporter Knock-in Mouse [PDF]

The Journal of Immunology, 2015
Abstract Many of the biological properties of C5a are mediated through activation of its receptor (C5aR1), the expression of which has been demonstrated convincingly on myeloid cells, such as neutrophils, monocytes, and macrophages. In contrast, conflicting results exist regarding C5aR1 expression in dendritic cells (DCs) and lymphoid ...
Christian M, Karsten, Yves, Laumonnier, Benjamin, Eurich, Fanny, Ender, Katharina, Bröker, Sreeja, Roy, Anna, Czabanska, Tillman, Vollbrandt, Julia, Figge, Jörg, Köhl   +9 more
openaire   +2 more sources

C5aR1 promotes acute pyelonephritis induced by uropathogenic E. coli [PDF]

JCI Insight, 2017
C5a receptor 1 (C5aR1) is a G protein-coupled receptor for C5a and also an N-linked glycosylated protein. In addition to myeloid cells, C5aR1 is expressed on epithelial cells. In this study, we examined the role of C5aR1 in bacterial adhesion/colonization of renal tubular epithelium and addressed the underlying mechanisms of this role.
Li K, Wu KY, Wu W, Wang N, Zhang T, Choudhry N, Song Y, Farrar CA, Ma L, Wei LL, Duan ZY, Dong X, Liu EQ, Li ZF, Sacks SH, Zhou W   +15 more
openaire   +3 more sources

Allergen-Induced C5a/C5aR1 Axis Activation in Pulmonary CD11b⁺ cDCs Promotes Pulmonary Tolerance through Downregulation of CD40

Cells, 2020
Activation of the C5/C5a/C5a receptor 1 (C5aR1) axis during allergen sensitization protects from maladaptive T cell activation. To explore the underlying regulatory mechanisms, we analyzed the impact of C5aR1 activation on pulmonary CD11b+ conventional ...
Konstantina Antoniou, Fanny Ender, Tillman Vollbrandt, Yves Laumonnier, Franziska Rathmann, Chandrashekhar Pasare, Harinder Singh, Jörg Köhl   +7 more
doaj   +1 more source

C5aR1-positive neutrophils promote breast cancer glycolysis through WTAP-dependent m6A methylation of ENO1

Cell Death and Disease, 2021
Neutrophils are significant compositions of solid tumors and exert distinct functions in different types of tumors. However, the precise role of neutrophils in the progression of breast cancer (BC) is presently unclear.
Baochi Ou, Yuan Liu, Xiaowei Yang, Xiaojun Xu, Yunwen Yan, Jingjie Zhang   +5 more
doaj   +1 more source

Ras-Related Protein Rab5a Regulates Complement C5a Receptor Trafficking, Chemotaxis, and Chemokine Secretion in Human Macrophages

Journal of Innate Immunity, 2023
Complement activation and Rab GTPase trafficking are commonly observed in inflammatory responses. Recruitment of innate immune cells to sites of infection or injury and secretion of inflammatory chemokines are promoted by complement component 5a (C5a ...
Kai-Chen Wu, Nicholas D Condon, Timothy A. Hill, Robert C. Reid, David Fairlie, Junxian Lim   +5 more
doaj   +1 more source