Results 41 to 50 of about 7,153 (219)
Differential regulation of C5a receptor 1 in innate immune cells during the allergic asthma effector phase. [PDF]
PLoS ONE, 2017 C5a drives airway constriction and inflammation during the effector phase of allergic asthma, mainly through the activation of C5a receptor 1 (C5aR1). Yet, C5aR1 expression on myeloid and lymphoid cells during the allergic effector phase is ill-defined ...
Fanny Ender +7 more
doaj +1 more source
Cancer Research, 2021 Abstract C5AR1 (complement C5a receptor 1) is a classical G protein-coupled receptor that is mainly expressed on granulocytes, monocytes, dendritic cells and MDSCs (Myeloid-derived suppressor cells) in several cancer types. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of immature cells that play a significant role ...
Yanhui Nie +4 more
openaire +1 more source
Journal of Neuroinflammation, 2023 The contribution of the gut microbiome to neuroinflammation, cognition, and Alzheimer’s disease progression has been highlighted over the past few years.
Tiffany J. Petrisko +5 more
doaj +1 more source
Inhibition of C5AR1 impairs osteoclast mobilization and prevents bone loss
Molecular Therapy, 2023 Age-related and chemotherapy-induced bone loss depends on cellular senescence and the cell secretory phenotype. However, the factors secreted in the senescent microenvironment that contribute to bone loss remain elusive. Here, we report a central role for the inflammatory alternative complement system in skeletal bone loss.
Carolina Pimenta-Lopes +9 more
openaire +2 more sources
Targeting C5aR1 Increases the Therapeutic Window of Radiotherapy [PDF]
, 2020 AbstractEngaging innate immune pathways is emerging as a productive way of achieving durable anti-tumor responses. However, systemic administration of these therapies can result in toxicity, deemed to be particularly problematic when combined with current standard-of-care cytotoxic treatments such as radiotherapy.
Monica M. Olcina +10 more
openaire +1 more source
Discovery of functionally selective C5aR2 ligands: novel modulators of C5a signalling. [PDF]
, 2016 The complement cascade is comprised of a highly sophisticated network of innate immune proteins that are activated in response to invading pathogens or tissue injury. The complement activation peptide, C5a, binds two seven transmembrane receptors, namely
Blaskovich, M.A. +11 more
core +1 more source
The Complement C5a-C5aR1 GPCR Axis in COVID-19 Therapeutics [PDF]
Trends in Immunology, 2020 The current pandemic of coronavirus disease (COVID-19) caused by SARS-CoV-2 is a significant global health challenge. A recent study by Carvelli and colleagues now demonstrates the involvement of complement C5a and its receptor C5aR1 in disease progression and suggests that blockade of the C5a-C5aR1 axis may represent a potential therapeutic strategy ...
Woodruff, Trent M., Shukla, Arun K.
openaire +3 more sources
The tumour microenvironment links complement system dysregulation and hypoxic signalling. [PDF]
, 2018 The complement system is an innate immune pathway typically thought of as part of the first line of defence against "non-self" species. In the context of cancer, complement has been described to have an active role in facilitating cancer-associated ...
Giaccia, Amato J +4 more
core +1 more source
Molecular Changes in Pre-Metastatic Lymph Nodes of Esophageal Cancer Patients [PDF]
, 2014 Lymph node metastasis indicates poor prognosis in esophageal cancer. To understand the underlying mechanisms, most studies so far focused on investigating the tumors themselves and/or invaded lymph nodes.
Izbicki, J.R. +9 more
core +10 more sources
Renal C3 complement component: feed forward to diabetic kidney disease [PDF]
, 2015 BACKGROUND: Diabetic nephropathy is the main cause of end-stage renal disease and has reached epidemic proportions. METHODS: Comprehensive genomic profiling (RNAseq) was employed in the ZS (F1 hybrids of Zucker and spontaneously hypertensive heart ...
Dominguez, Jesus H. +3 more
core +2 more sources