Results 51 to 60 of about 7,153 (219)
OncoImmunology, 2023 High-grade serous ovarian cancer (HGSC), with a modest response to immune checkpoint blockade (ICB) targeting PD-1/PD-L1 monotherapy, is densely infiltrated by M2-polarized tumor-associated macrophages (TAMs) and regulatory T (Treg) cells. The complement
Chen Zhang +8 more
doaj +1 more source
Local endothelial complement activation reverses endothelial quiescence, enabling t-cell homing, and tumor control during t-cell immunotherapy. [PDF]
, 2017 Cancer immunotherapy relies upon the ability of T cells to infiltrate tumors. The endothelium constitutes a barrier between the tumor and effector T cells, and the ability to manipulate local vascular permeability could be translated into effective ...
Balint, K. +14 more
core +2 more sources
Intracellular complement C5a/C5aR1 stabilizes β-catenin to promote colorectal tumorigenesis
Cell Reports, 2022 Complement is operative in not only the extracellular but also the intracellular milieu. However, little is known about the role of complement activation inside tumor cells. Here, we report that intracellular C5 is cleaved by cathepsin D (CTSD) to produce C5a in lysosomes and endosomes of colonic cancer cells.
Peipei Ding +13 more
openaire +2 more sources
PLoS ONE, 2021 The complement component C5a and its receptor C5aR1 are involved in the development of numerous inflammatory diseases. In addition to immune cells, C5aR1 is expressed in neoplastic cells of multiple tumour entities, where C5aR1 is associated with a ...
Benjamin Nürge +6 more
doaj +1 more source
Frontiers in Endocrinology, 2022 In recent years, evidence has accumulated that the complement system, an integral part of innate immunity, may be involved in the regulation of bone homeostasis as well as inflammatory bone loss, for example, in rheumatoid arthritis and periodontitis.
Jasmin Maria Bülow +9 more
openaire +4 more sources
Future Needs in Mast Cell Biology. [PDF]
, 2019 The pathophysiological roles of mast cells are still not fully understood, over 140 years since their description by Paul Ehrlich in 1878. Initial studies have attempted to identify distinct "subpopulations" of mast cells based on a relatively small ...
de Paulis, Amato +3 more
core +2 more sources
Mammalian cryptochromes impinge on cell cycle progression in a circadian clock-independent manner [PDF]
, 2011 By gating cell cycle progression to specific times of the day, the intracellular circadian clock is thought to reduce the exposure of replicating cells to potentially hazardous environmental and endogenous genotoxic compounds.
Destici Eugin +4 more
core +1 more source
Helix 8 in chemotactic receptors of the complement system.
PLoS Computational Biology, 2022 Host response to infection involves the activation of the complement system leading to the production of anaphylatoxins C3a and C5a. Complement factor C5a exerts its effect through the activation of C5aR1, chemotactic receptor 1, and triggers the G ...
Szymon Wisniewski +3 more
doaj +1 more source
Complement in the homeostatic and ischemic brain [PDF]
, 2015 The complement system is a component of the immune system involved in both recognition and response to pathogens, and it is implicated in an increasing number of homeostatic and disease processes. It is well documented that reperfusion of ischemic tissue
Aivazian +129 more
core +3 more sources
Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo [PDF]
, 2013 Neutrophil recruitment from blood to extravascular sites of sterile or infectious tissue damage is a hallmark of early innate immune responses, and the molecular events leading to cell exit from the bloodstream have been well defined1,2. Once outside the
Afonso, P. +6 more
core +2 more sources