Results 61 to 70 of about 7,153 (219)

TPST2-mediated receptor tyrosine sulfation enhances leukocidin cytotoxicity and S. aureus infection

Frontiers in Immunology, 2023
BackgroundAn essential fact underlying the severity of Staphylococcus aureus (S. aureus) infection is the bicomponent leukocidins released by the pathogen to target and lyse host phagocytes through specific binding cell membrane receptors.
Jie He, Xianggui Yang, Kai Yang, Honglin Xu, Cheng Chen, Junxiong Wang, Jun Zeng   +6 more
doaj   +1 more source

Inflammasome priming in sterile inflammatory disease [PDF]

, 2017
The inflammasome is a cytoplasmic protein complex that processes interleukins (IL)-1β and IL-18, and drives a form of cell death known as pyroptosis. Oligomerization of this complex is actually the second step of activation, and a priming step must occur
Bryant, Clare E., Carroll, Richard G., Galván-Peña, Silvia, Masters, Seth L., Mills, Evanna L., Olden, Robin, Patel, Meghana N., Triantafilou, Kathy, Triantafilou, Martha, Wolf, Amaya I.   +9 more
core   +2 more sources

Dysregulated signaling, proliferation and apoptosis impact on the pathogenesis of TCRγδ+ T cell large granular lymphocyte leukemia [PDF]

, 2017
TCRγδ+ T-LGL leukemia is a rare form of chronic mature T cell disorders in elderly, which is generally characterized by a ...
De Ridder, D. (Dick), Dongen, J.J.M. (Jacques) van, Kallemeijn, M.J. (Martine), Langerak, A.W. (Anton), Sandberg, Y. (Yorick), Schilperoord-Vermeulen, J. (Joyce), Van Der Klift, M.Y. (Michèle Y.)   +6 more
core   +1 more source

C5aR1 is a master regulator in Colorectal Tumorigenesis via Immune modulation

Theranostics, 2020
Numerous factors have been claimed to play important roles in colorectal cancer (CRC) tumorigenesis, including myeloid-derived suppressor cells (MDSCs) and other immune cells, cytokines, and chemokines; however, the precise mechanisms of colorectal tumorigenesis remain elusive, and there is a lack of effective preventive treatments.
Ding, Peipei, Li, Ling, Li, Luying, Lv, Xinyue, Zhou, Danlei, Wang, Qingkai, Chen, Jianfeng, Yang, Chaoqun, Xu, Enjie, Dai, Weixing, Zhang, Xin, Wang, Na, Wang, Qi, Zhang, Wei, Zhang, Long, Zhou, Yuzhen, Gu, Hongyu, Lei, Qunying, Zhou, Xuhui, Hu, Weiguo   +19 more
openaire   +2 more sources

Modulation of porcine intestinal epitheliocytes immunetranscriptome response by Lactobacillus jensenii TL2937 [PDF]

, 2016
In order to evaluate probiotic strains applicable for the beneficial immunomodulation of the porcine gut (immunobiotics), we previously developed a porcine intestinal epitheliocyte cell line (PIE cells).
Albarracín, Leonardo Miguel, Aso, Hisashi, Ikeda-Ohtsubo, Wakako, Kanmani, Paulraj, Kano, Hiroshi, Kitazawa, Haruki, Kobayashi, Hisakazu, Kober, Humayun A.K.M., Makino, Seiya, Nochi, Tomonori, Ohkawara, Sou, Saito, Tadao, Sato, Nana, Suda, Yoshihito, Villena, Julio Cesar   +14 more
core   +1 more source

Global impact of Salmonella type III secretion effector SteA on host cells [PDF]

, 2014
Salmonella enterica is a Gram-negative bacterium that causes gastroenteritis, bacteremia and typhoid fever in several animal species including humans. Its virulence is greatly dependent on two type III secretion systems, encoded in pathogenicity islands ...
Cardenal Muñoz, Elena, Gutiérrez Pozo, Gabriel, Ramos Morales, Francisco   +2 more
core   +1 more source

Complement C5a-C5aR1 signalling drives skeletal muscle macrophage recruitment in the hSOD1G93A mouse model of amyotrophic lateral sclerosis

Skeletal Muscle, 2017
Background The terminal pathway of the innate immune complement system is implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). Terminal complement activation leads to generation of C5a, which through its receptor, C5aR1, drives immune ...
Haitao A. Wang, John D. Lee, Kah Meng Lee, Trent M. Woodruff, Peter G. Noakes   +4 more
doaj   +1 more source

Complement C5a Receptor Signaling Alters Stress Responsiveness and Modulates Microglia Following Chronic Stress Exposure

Biological Psychiatry Global Open Science
Background: Accumulating evidence underscores the pivotal role of heightened inflammation in the pathophysiology of stress-related diseases, but the underlying mechanisms remain elusive.
Hsiao-Jou Cortina Chen, Jereme G. Spiers, Titaya Lerskiatiphanich, Sandra E. Parker, Nickolas A. Lavidis, Jenny N. Fung, Trent M. Woodruff, John D. Lee   +7 more
doaj   +1 more source

Differential Contributions of the Complement Anaphylotoxin Receptors C5aR1 and C5aR2 to the Early Innate Immune Response against Staphylococcus aureus Infection

Pathogens, 2015
The complement anaphylatoxin C5a contributes to host defense against Staphylococcus aureus. In this study, we investigated the functional role of the two known C5a receptors, C5aR1 and C5aR2, in the host response to S. aureus. We found that C5aR1−/− mice
Sarah A. Horst, Andreas Itzek, Andreas Klos, Andreas Beineke, Eva Medina   +4 more
doaj   +1 more source

Paclitaxel binds and activates C5aR1: A new potential therapeutic target for the prevention of chemotherapy-induced peripheral neuropathy and hypersensitivity reactions

Cell Death and Disease, 2022
Chemotherapy-induced peripheral neuropathy (CIPN) and hypersensitivity reactions (HSRs) are among the most frequent and impairing side effects of the antineoplastic agent paclitaxel.
Laura Brandolini, Michele d’Angelo, Rubina Novelli, Vanessa Castelli, Cristina Giorgio, Anna Sirico, Pasquale Cocchiaro, Francesco D’Egidio, Elisabetta Benedetti, Claudia Cristiano, Antonella Bugatti, Anna Ruocco, Pier Giorgio Amendola, Carmine Talarico, Candida Manelfi, Daniela Iaconis, Andrea Beccari, Andreza U. Quadros, Thiago M. Cunha, Arnaldo Caruso, Roberto Russo, Annamaria Cimini, Andrea Aramini, Marcello Allegretti   +23 more
doaj   +1 more source