Results 71 to 80 of about 7,153 (219)

Differential expression of C5aR1 and C5aR2 in innate and adaptive immune cells located in early skin lesions of bullous pemphigoid patients

Frontiers in Immunology, 2022
Bullous pemphigoid (BP), the by far most frequent autoimmune subepidermal blistering disorder (AIBD), is characterized by the deposition of autoantibodies against BP180 (type XVII collagen; Col17) and BP230 as well as complement components at the dermal ...
Shirin Emtenani, Maike M. Holtsche, Richard Stahlkopf, Daniel L. Seiler, Timothy Burn, Huiqing Liu, Melissa Parker, Kaan Yilmaz, Hasan O. Dikmen, Markus Huber Lang, Christian D. Sadik, Christian M. Karsten, Nina van Beek, Ralf J. Ludwig, Ralf J. Ludwig, Jörg Köhl, Jörg Köhl, Enno Schmidt, Enno Schmidt   +18 more
doaj   +1 more source

A novel anticonvulsant mechanism via inhibition of complement receptor C5ar1 in murine epilepsy models

Neurobiology of Disease, 2015
The role of complement system-mediated inflammation is of key interest in seizure and epilepsy pathophysiology, but its therapeutic potential has not yet been explored.
Melissa J. Benson, Nicola K. Thomas, Sahil Talwar, Mark P. Hodson, Joseph W. Lynch, Trent M. Woodruff, Karin Borges   +6 more
doaj   +1 more source

From traumatic childhood to cocaine abuse: the critical function of the immune system [PDF]

, 2018
Background: Experiencing traumatic childhood is a risk factor for developing substance use disorder (SUD), but the mechanisms that underlie this relationship have not been determined.
Aricò, Eleonora, Bussone, Silvia, Carola, Valeria, Casella, Pietro, Catale, Clarissa, Chiurchiù, Valerio, Di Sabato, Paola, D’Argenio, Alberto, Guatteo, Ezia, Lo Iacono, Luisa, Maccarrone, Mauro, Martini, Alessandro, Mercuri, Nicola B., Perrone, Fabiana, Puglisi-Allegra, Stefano, Troisi, Alfonso, Valzania, Alessandro, Viscomi, Maria Teresa   +17 more
core   +1 more source

The C5a/C5aR1 Axis Contributes to the Pathogenesis of Acute Cystitis Through Enhancement of Adhesion and Colonization of Uropathogenic E. coli

Frontiers in Cellular and Infection Microbiology, 2022
Our previous work using a murine model of pyelonephritis demonstrated that the C5a/C5aR1 axis plays a pathogenic role in acute kidney infection. In this study, we report that the C5a/C5aR1 axis also plays a pathogenic role in acute bladder infection ...
Kun-Yi Wu, Bo Cao, Chun-Xuan Wang, Xue-Ling Yang, Shu-Juan Zhao, Teng-Yue Diao, Li-Rong Lin, Guo-Xiu Zhao, Wuding Zhou, Ju-Rong Yang, Ke Li   +10 more
doaj   +1 more source

Siah2 control of T-regulatory cells limits anti-tumor immunity. [PDF]

, 2020
Understanding the mechanisms underlying anti-tumor immunity is pivotal for improving immune-based cancer therapies. Here, we report that growth of BRAF-mutant melanoma cells is inhibited, up to complete rejection, in Siah2-/- mice.
Aifantis, Ioannis, Bosenberg, Marcus, Bradley, Linda M, Brown, Kevin, Dolgalev, Igor, Feng, Yongmei, Hockemeyer, Kathryn, Li, Yan, Marine, Jean-Christophe, Otero, Dennis C, Poźniak, Joanna, Rambow, Florian, Ronai, Ze'ev A, Scortegagna, Marzia, Tinoco, Roberto, Zhang, Tongwu   +15 more
core   +2 more sources

Potential Mechanisms Underlying TGF-β-mediated Complement Activation in Lung Fibrosis [PDF]

, 2017
While our previous studies suggest that limiting bleomycin-induced complement activation suppresses TGF-β signaling, the specific hierarchical interactions between TGF-β and complement in lung fibrosis are unclear.
Cipolla, Ellyse, Fisher, Amanda J., Gu, Hongmei, Mickler, Elizabeth A., Varre, Ananya, Vittal, Ragini   +5 more
core   +2 more sources

C5aR1 Promotes Invasion, Metastasis, and Poor Prognosis in Cutaneous Squamous Cell Carcinoma

The American Journal of Pathology
Cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer, and the metastatic from is associated with a poor prognosis. Here, the role of the complement C5a receptor C5aR1 was examined in the progression and metastasis of cSCC.
L. Heiskanen, L. Nissinen, E. Siljamäki, J. Knuutila, T. Pellinen, M. Kallajoki, J. Heino, P. Riihilä, V. Kähäri   +8 more
semanticscholar   +4 more sources

Monocyte LOXHD1 and RHOB Expression Predictive of Progressive Systemic Sclerosis–Associated Interstitial Lung Disease

Arthritis Care &Research, EarlyView.
Objective A leading cause of death among patients with scleroderma (SSc), interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monitoring and aggressive therapy would be an essential clinical tool.
Cristina M. Padilla, Robert Lafyatis, Kevin F. Gibson, Christina Morse, Eleanor Valenzi, Xiaoping Chen, Xiaoyun Li, Yanwu Zhao, Yongseok Park, Dana Ascherman, Jonathan Minden, Robyn Domsic, Yingze Zhang, Daniel J. Kass   +13 more
wiley   +1 more source

Anaphylatoxin Receptors C3aR and C5aR1 Are Important Factors That Influence the Impact of Ethanol on the Adipose Secretome

Frontiers in Immunology, 2018
Background and aims: Chronic ethanol exposure results in inflammation in adipose tissue; this response is associated with activation of complement as well as the development of alcohol-related liver disease (ALD).
Rebecca L. McCullough, Megan R. McMullen, Kyle L. Poulsen, Adam Kim, M. Edward Medof, Laura E. Nagy, Laura E. Nagy   +6 more
doaj   +1 more source

Persistent immune stimulation exacerbates genetically driven myeloproliferative disorders via stromal remodeling [PDF]

, 2017
Systemic immune stimulation has been associated with increased risk of myeloid malignancies, but the pathogenic link is unknown. We demonstrate in animal models that experimental systemic immune activation alters the bone marrow stromal microenvironment,
Botti, Laura, Burocchi, Alessia, Cappetti, Barbara, Chiodoni, Claudia, Colombo, Mario P., Falini, Brunangelo, Gulino, Alessandro, Isidori, Alessandro, Liso, Arcangelo, Martelli, Maria Paola, Pandolfi, Pier Paolo, Piccaluga, Pier Paolo, Portararo, Paola, Sangaletti, Sabina, Tripodo, Claudio, Visani, Giuseppe   +15 more
core   +1 more source