Results 81 to 90 of about 7,153 (219)

Citalopram exhibits immune-dependent anti-tumor effects by modulating C5aR1+ TAMs

bioRxiv
Administration of selective serotonin reuptake inhibitors (SSRIs) is associated with a reduced cancer risk and shows significant anti-tumor effects across multiple tumor types, suggesting the potential for repurposing SSRIs in cancer therapy. Nonetheless,
Fang-yuan Dong, Shan Zhang, Kaiyuan Song, Luju Jiang, Lipeng Hu, Qing Li, Xue-Li Zhang, Jun Li, Mingxuan Feng, Zhi-Wei Cai, Hong-Fei Yao, Rong-Kun Li, Hui Li, Jie Chen, Xiaona Hu, Jiao-feng Wang, Chongyi Jiang, Helen He Zhu, Cun Wang, Lin-Tai Da, Zhignang Zhang, Zhijun Bao, Xu Wang, Shuheng Jiang   +23 more
semanticscholar   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Safety and feasibility of Lin- cells administration to ALS patients : a novel view on humoral factors and miRNA profiles [PDF]

, 2018
Therapeutic options for amyotrophic lateral sclerosis (ALS) are still limited. Great hopes, however, are placed in growth factors that show neuroprotective abilities (e.g., nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and vascular
Baumert, Bartłomiej, Dulak, Józef, Gołąb-Janowska, Monika, Gródecka-Szwajkiewicz, Dorota, Kawa, Miłosz P., Kotowski, Maciej, Litwińska, Zofia, Machaliński, Bogusław, Nowacki, Przemysław, Peregud-Pogorzelski, Jarosław, Pius-Sadowska, Ewa, Sobuś, Anna, Stępniewski, Jacek   +12 more
core   +2 more sources

Prenatal betamethasone–postnatal N‐methyl‐D‐aspartic acid model of spasms: Update on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Infantile epilepsy spasms syndrome (IESS), formerly known as infantile spasms or West Syndrome, is a severe epilepsy syndrome affecting about 3 in 10,000 newborns in the United States. Characterized by clusters of epileptic spasms, interictal hypsarrhythmia, and developmental delays, IESS has diverse causes, including structural‐metabolic ...
Kayla Vieira, Antonia Schonwald, Chian‐Ru Chern, Kamya Shah, Jana Velíšková, Libor Velíšek   +5 more
wiley   +1 more source

Finding the association of mRNA and miRNA using Next Generation Sequencing data of Kidney renal cell carcinoma [PDF]

, 2017
MicroRNAs (miRNAs) are a class of 22-nucleotide endogenous noncod- ing RNAs, plays important role in regulating target gene expression via repress- ing translation or promoting messenger RNAs (mRNA) degradation.
A Grada, A Sharma, D Yu, H Peng, I Guyon, Indrajit Saha, L Breiman, M Sehhati, Maxim V. Kuleshov, MD Robinson, Nathan Wong, P Leidinger, Simon Anders, Tzu-Pin Lu, X Lu   +14 more
core   +1 more source

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, EarlyView.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

Finerenone Alleviates Over-Activation of Complement C5a-C5aR1 Axis of Macrophages by Regulating G Protein Subunit Alpha i2 to Improve Diabetic Nephropathy

Cells
Diabetic nephropathy (DN), one of the most common complications of diabetes mellitus (DM), accounts for a major cause of chronic kidney disease (CKD) worldwide, with a complicated pathogenesis and limited effective strategies nowadays.
Zi-Han Li, Zi-Jun Sun, Sydney C. W. Tang, Ming-Hui Zhao, Min Chen, D. Chang   +5 more
semanticscholar   +1 more source

Deciphering diverse cell‐death patterns to predict the prognosis and potential therapy target of hepatocellular carcinoma patients

VIEW, EarlyView.
Abstract Ninety percent of all primary liver malignancies are hepatocellular carcinomas (HCC), making liver cancer the third most common cause of cancer‐associated mortality. Different patterns of programmed cell death (PCD) are crucial for the survival of tumors, and they might serve as a prognostic marker for HCC.
Lin Ding, Qian Li, Wenjing Yang, Te Liu, Tongtong Tian, Yu Liu, Chunyan Zhang, Baishen Pan, Beili Wang, Fan Wu, Wei Guo   +10 more
wiley   +1 more source

The role of the complement system in traumatic brain injury: a review [PDF]

, 2018
Traumatic brain injury (TBI) is an important cause of disability and mortality in the western world. While the initial injury sustained results in damage, it is the subsequent secondary cascade that is thought to be the significant determinant of ...
A Alawieh, A Jauneau, A Kumar, Adnan Hammad, AG Therien, AH Stephan, AI Faden, AL Vescovi, B Oderfeld-Nowak, B Stevens, B-M Bellander, B-M Bellander, B-M Bellander, BJ Gabbe, BP Morgan, BP Morgan, C Cudrici, C Wang, CA Colton, CG Cochrane, D Cederberg, D Dupret, D Ricklin, D Shlosberg, DG Nicholls, DL Sewell, DN Abrous, DP Ankeny, DP Schafer, DT Fearon, E Makou, ED Ponomarev, EO Samstad, F Orsini, F Qiao, FH Brennan, G Arbore, G Winocur, GM Pasinetti, GT Manley, H Osaka, HD Manthey, HG Rus, HG Rus, HX Nguyen, I Leinhase, I Leinhase, I Leinhase, IP Karve, J Rogers, J van Beek, J van Beek, J Wetherington, JJ Ramirez, JL Cole, JR Dunkelberger, K Fluiter, K Färber, K Heese, K Järlestedt, K Pisalyaput, KA Kigerl, L Berliocchi, L Boos, L Longhi, L Longhi, L Soane, Laura Westacott, LG Coulthard, M Bénard, M Bénard, M Fosbrink, M Lévi-Strauss, M Moriyama, M Rancan, M-C Mathieu, Malik Zaben, MC Carroll, MC Carroll, MC Garrett, MD Saxe, ME Benoit, ME Medof, MJ Rutkowski, MK Liszewski, ML Pearn, MM Ruseva, N Sanai, N Shinjyo, NA Martin, O Butovsky, P Gasque, PF Stahel, PF Stahel, PF Stahel, PF Stahel, PH Yager, Q Shi, R Beschorner, R Knoth, RM Chesnut, RM Ransohoff, RS Ames, S Fumagalli, S Nataf, S Nataf, S Yang, SH Weerth, SK Ludwin, SL Kaczorowski, T Fujita, T Kossmann, TA Rupprecht, TJ Shors, U Amara, VM Holers, W Zheng, WH Kwan, X de la Rosa, X Jin, Y Chu, Y Rahpeymai, Y Xiong, YR Bogestål, Z You   +124 more
core   +1 more source

C5aR1 signaling promotes region‐ and age‐dependent synaptic pruning in models of Alzheimer's disease

Alzheimer's & Dementia
Synaptic loss is a hallmark of Alzheimer's disease (AD) that correlates with cognitive decline in AD patients. Complement‐mediated synaptic pruning has been associated with this excessive loss of synapses in AD.
Angela Gomez-Arboledas, M. Fonseca, E. Kramár, Shu-Hui Chu, Nicole D. Schartz, Purnika Selvan, Marcelo A. Wood, Andrea J. Tenner   +7 more
semanticscholar   +1 more source