Results 31 to 40 of about 65,722 (350)

Interplay between integrins and cadherins to control bone differentiation upon BMP-2 stimulation

Frontiers in Cell and Developmental Biology, 2023
Introduction: Upon BMP-2 stimulation, the osteoblastic lineage commitment in C2C12 myoblasts is associated with a microenvironmental change that occurs over several days.
Anne Valat, Laure Fourel, Adria Sales, Paul Machillot, Paul Machillot, Anne-Pascale Bouin, Carole Fournier, Lauriane Bosc, Mélanie Arboléas, Ingrid Bourrin-Reynard, Amy J. Wagoner Johnson, Amy J. Wagoner Johnson, Amy J. Wagoner Johnson, Amy J. Wagoner Johnson, Franz Bruckert, Corinne Albigès-Rizo, Catherine Picart, Catherine Picart, Catherine Picart   +18 more
doaj   +1 more source

“Switch of E-Cadherin to N-Cadherin expression in different molecular subtypes of breast invasive duct carcinomas and its correlation with clinicopathological features”

Indian Journal of Pathology and Microbiology, 2021
Background: In breast cancer, metastasis and recurrence is the main culprit in treatment failure. This study aimed to explore the role of E-cadherin/N-cadherin Switch in progression, spread and metastasis in breast invasive duct carcinoma.
Mayada S Farrag, Abeer H Anter, Nesrine S Farrag, Afaf T Ibrahiem   +3 more
doaj   +1 more source

Foxp1 and lhx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling. [PDF]

, 2010
Topographic neuronal maps arise as a consequence of axon trajectory choice correlated with the localisation of neuronal soma, but the identity of the pathways coordinating these processes is unknown.
Kania, Artur, Kao, Tzu-Jen, Klar, Avihu, Laufer, Ed, Novitch, Bennett G, Okamoto, Hitoshi, Palmesino, Elena, Rousso, David L, Uemura, Osamu   +8 more
core   +4 more sources

A Scoping Review of the Role of Metalloproteinases in the Pathogenesis of Autoimmune Pemphigus and Pemphigoid

Biomolecules, 2021
Pemphigus and pemphigoid diseases are potentially life-threatening autoimmune blistering disorders that are characterized by intraepithelial and subepithelial blister formation, respectively. In both disease groups, skin and/or mucosal blistering develop
Nicola Cirillo, Stephen S. Prime
doaj   +1 more source

Patterns in Space: Coordinating Adhesion and Actomyosin Contractility at E-cadherin Junctions

, 2013
Cadherin adhesion receptors are fundamental determinants of tissue organization in health and disease. Increasingly, we have come to appreciate that classical cadherins exert their biological actions through active cooperation with the contractile actin ...
Wu, Selwin K., Yap, Alpha S.
core   +1 more source

VE-cadherin and claudin-5: it takes two to tango [PDF]

, 2008
Endothelial barrier function requires the adhesive activity of VE-cadherin and claudin-5, which are key components of adherens and tight endothelial junctions, respectively.
A Taddei, AS Yap, D Hoogeboom, E Dejana, J Gavard, J Rhee, J. Silvio Gutkind, Julie Gavard, MAG Essers, MG Lampugnani, P Carmeliet, R Paul, S Tsukita, S van Wetering, S Weis, T Nitta, VV Orlova, WJ Nelson   +17 more
core   +5 more sources

Lactoferrin's anti-cancer properties. Safety, selectivity, and wide range of action [PDF]

, 2020
Despite recent advances in cancer therapy, current treatments, including radiotherapy, chemotherapy, and immunotherapy, although beneficial, present attendant side effects and long-term sequelae, usually more or less affecting quality of life of the ...
Bonaccorsi di Patti, M. C., Cutone, A., Ianiro, G., Lepanto, M. S., Musci, G., Rosa, L., Valenti, P.   +6 more
core   +1 more source

Anticancer Activity of Holothuria Leucospilota-Derived Saponin on MKN45 Gastric Cancer Cell via Upregulation of CDH1 Hub Gene [PDF]

Middle East Journal of Cancer
Background: The treatment of gastric cancer (GC) is still quite challenging. Yet, marine invertebrates have been found to produce a wide range of anticancer bioactive compounds that show promise in fighting cancer.
Khadijeh Sadegh, Amirhossein Ahmadi, Ahmad Shadi, Ahmad Ghasemi   +3 more
doaj   +1 more source

Cadherin Expression and EMT: A Focus on Gliomas

Biomedicines, 2021
Cadherins are calcium-binding proteins with a pivotal role in cell adhesion and tissue homeostasis. The cadherin-dependent mechanisms of cell adhesion and migration are exploited by cancer cells, contributing to tumor invasiveness and dissemination.
Carolina Noronha, Ana Sofia Ribeiro, Ricardo Taipa, Diogo S. Castro, Joaquim Reis, Cláudia Faria, Joana Paredes   +6 more
doaj   +1 more source

Cadherins and catenins in cancer: connecting cancer pathways and tumor microenvironment

Frontiers in Cell and Developmental Biology, 2023
Cadherin-catenin complexes are integral components of the adherens junctions crucial for cell-cell adhesion and tissue homeostasis. Dysregulation of these complexes is linked to cancer development via alteration of cell-autonomous oncogenic signaling ...
Wan-Hsin Lin, Lisa M. Cooper, Panos Z. Anastasiadis   +2 more
doaj   +1 more source