Results 101 to 110 of about 1,364 (167)

RUSS-AGE study: Markers of carbohydrate metabolism and their time course in different age groups of a healthy population of the Russian Federation

Consilium Medicum
Background. One of the important tasks of modern science is to search for key biomarkers of aging of various body systems. Parameters of carbohydrate metabolism play an essential role in maintaining vital activity.
Anna K. Ilyushchenko, Arina E. Veriaskina, Lubov V. Machekhina, Aleksandra A. Melnitskaia, Olga N. Tkacheva, Andrey A. Tyazhelnikov, Valeriy S. Polunin, Alexander V. Iumukian, Irina D. Strazhesko   +8 more
doaj   +1 more source

N-epsilon-carboxymethyllysine in brain aging, diabetes mellitus, and Alzheimer\u27s disease

Oxidative stress has been implicated in the pathophysiology of Alzheimer\u27s disease (AD) and diabetes mellitus (DM). N-epsilon-Carboxymethyllysine (CML) is an advanced glycation end product (AGE) recently found to be associated with oxidative stress ...
Girones X, Makita Z, Cruz-Sanchez CZ, Guimera A, Cruz-Sanchez FF, Ortega A, Sasaki N, Lafuente JV, Kalaria R   +8 more
core  

Quantitation of Nε-carboxymethyllysine and Nε-carboxyethyllysine in oxidative stressor exposed cells by liquid chromatography tandem mass spectrometry

, 2019
Advanced glycation end-products (AGEs) are a large group of compounds originated from the Maillard reaction. Their formation and accumulation in human body are closely related to aging and various degenerative diseases.
Wong, Sum Kok
core  

Comparison of Anti-Acute Phase Effect of CIGB-258 and Its Wild-Type Peptide (E18-3) in a Hyperinflammatory and Acute Bleeding Model of Zebrafish: A Surface Plasmon Resonance Study to Compare Binding Affinity with High-Density Lipoproteins. [PDF]

Int J Mol Sci
Cho KH, Lee Y, Lee SH, Bahuguna A, Hee Baek S, Domínguez-Horta MDC, Martínez-Donato G.   +6 more
europepmc   +1 more source

Synergistic Anti-Inflammatory Activity of Apolipoprotein A-I and CIGB-258 in Reconstituted High-Density Lipoproteins (rHDL) against Acute Toxicity of Carboxymethyllysine in Zebrafish and Its Embryo

CIGB-258 is a 3 kDa altered peptide ligand from heat shock protein (HSP) 60 that exhibits anti-inflammatory activity against the acute toxicity of carboxymethyllysine (CML) with antioxidant and anti-glycation activities via protection of high-density ...
Maria del Carmen Dominguez-Horta, Ji-Eun Kim, Dae-Jin Kang, Kyung-Hyun Cho, Gillian Martinez-Donato   +4 more
core   +1 more source

Multi-Response Kinetic Modeling of the Maillard Reaction in Milk During Heating at Ultra-High-Temperature Range. [PDF]

J Agric Food Chem
Hamzalıoǧlu A, Aktaǧ I, Gökmen V.
europepmc   +1 more source

Increase in the advanced glycation end product pentosidine in Bruch's membrane with age

, 1999
PURPOSE. To determine whether there is an age-related increase of pentosidine in human Bruch's membranes and to localize pentosidine and carboxymethyllysine (CML), two well-characterized, advanced glycation end products (AGEs) in aged human Bruch's ...
Koppele, J.M. te, Matsunaga, H., Lutty, G.A., Verzijl, N., Hjelmeland, L.M., Handa, J.T., Aotaki-Keen, A., Miyata, T.   +7 more
core  

Advanced glycation end-products and sclerostin are elevated across diabetes phenotypes and associated with vertebral fractures in type 2 diabetes. [PDF]

BMC Endocr Disord
Taskin Kursun S, Imre E, Gogas Yavuz D.
europepmc   +1 more source

Effects of N-carboxymethyllysine on Osteogenesis and Adipogenesis

, 2010
羧甲基離胺酸(CML)為最終糖化產物(AGEs)的主要成分，在糖尿病以及老化之人的血管以及組織中，常常發現有累積的現象而導致其他併發症，如:骨質疏症。先前研究發現AGEs 可調控骨髓間質幹細胞的分化作用，包括脂肪細胞化以及造骨細胞分化。但是至今其分子機制尚未了解。此本篇主要探討羧甲基離胺酸對於間質幹細胞分化成造骨細胞以及脂肪細的影響。首先我們先利用MTT 試驗來選定不造成細胞死亡的使用劑量: 25μ/ml，發現在此劑量下能夠有效抑制造骨細胞分化主要是透過促進RAGE、NOS、,NO ...
陳帝瑞, Chen, Ti-Jui
core  

Metabolic Landscape and Cell-Type-Specific Transcriptional Signatures Associated with Dopamine Receptor Activation in the Honeybee Brain. [PDF]

Biology (Basel)
Zhang M, Xu K, Xu M, Li J, Xu Y, Niu Q, Li X, Chen P.   +7 more
europepmc   +1 more source