Results 81 to 90 of about 1,364 (167)

High Serum Advanced Glycation End Products Are Associated with Decreased Insulin Secretion in Patients with Type 2 Diabetes: A Brief Report

Journal of Diabetes Research, 2017
Objective. Advanced glycation end products (AGEs) are important in the pathophysiology of type 2 diabetes mellitus (T2DM). They directly cause insulin secretory defects in animal and cell culture models and may promote insulin resistance in nondiabetic ...
Tsuyoshi Okura, Etsuko Ueta, Risa Nakamura, Yohei Fujioka, Keisuke Sumi, Kazuhisa Matsumoto, Kyoko Shoji, Kazuhiko Matsuzawa, Shoichiro Izawa, Yuri Nomi, Hitomi Mihara, Yuzuru Otsuka, Masahiko Kato, Shin-ichi Taniguchi, Kazuhiro Yamamoto   +14 more
doaj   +1 more source

Advanced glycation end products and protein carbonyl levels in plasma reveal sex-specific differences in Parkinson's and Alzheimer's disease

Redox Biology, 2020
Neurodegenerative diseases (NDD) such as Alzheimer's (AD) and Parkinson's disease (PD) are distinct clinical entities, however, the aggregation of key neuronal proteins, presumably leading to neuronal demise appears to represent a common mechanism.
Amit Sharma, Daniela Weber, Jana Raupbach, Tikam Chand Dakal, Klaus Fließbach, Alfredo Ramirez, Tilman Grune, Ullrich Wüllner   +7 more
doaj   +1 more source

Temporal increases in urinary carboxymethyllysine correlate with albuminuria development in diabetes

, 2011
Background/Aims: Advanced glycation end products (AGEs) mediate progressive tissue damage in diabetic nephropathy; however, their utility as a noninvasive reliable biomarker of progressive diabetic nephropathy remains to be determined.
Josephine M. Forbes, Coughlan, Melinda T., Forbes, Josephine M., Melinda T. Coughlan   +3 more
core   +1 more source

Anti-Inflammatory Activity of CIGB-258 against Acute Toxicity of Carboxymethyllysine in Paralyzed Zebrafish via Enhancement of High-Density Lipoproteins Stability and Functionality

, 2022
Background: Hyperinflammation is frequently associated with the chronic pain of autoimmune disease and the acute death of coronavirus disease (COVID-19) via a severe cytokine cascade.
Na, Hye-Jee, Hye-Jee Na, Kim, Ji-Eun, Nam, Hyo-Seon, Hyo-Seon Nam, Kang, Dae-Jin, Ji-Eun Kim, Dae-Jin Kang, Kyung-Hyun Cho, Cho, Kyung-Hyun   +9 more
core   +1 more source

Study of the urinary and faecal excretion of N ε-carboxymethyllysine in young human volunteers

, 2011
The dietary habits of the adolescent population with a high intake of snack and fast foods mean that they consume a high rate of which in turn leads to the development of different degenerative disorders. There are few studies available on MRP absorption
Frédéric J. Tessier, Tessier, Frédéric J., Céline Niquet-Leridon, Navarro, María Pilar, Isabel Seiquer, Delgado-Andrade, Cristina, Cristina Delgado-Andrade, Niquet-Leridon, Céline, M. Pilar Navarro, Seiquer, Isabel   +9 more
core   +1 more source

Nε-carboxymethyllysine in nutritional milk formulas for infants

, 2018
Production of infant formulas involves high temperature processing for microbiological safety. However, heat processes generate Advanced Glycation End-products (AGEs), including Nε-carboxymethyllysine (CML) formed between lysine and lactose.
Alison Hodgkinson (15394178), Elizabeth Carpenter (15397100), Colin Prosser (15395060)   +2 more
core  

Advanced glycation end product Nε-carboxymethyllysine induces endothelial cell injury: the involvement of SHP-1-regulated VEGFR-2 dephosphorylation

, 2013
Nε-carboxymethyllysine (CML), a major advanced glycation end product, plays a crucial role in diabetes-induced vascular injury. The roles of protein tyrosine phosphatases and vascular endothelial growth factor (VEGF) receptors in CML-related endothelial ...
Pan, Hung Chuan, Tzung Jie Yang, Wayne Huey Herng Sheu, Lee, Maw Rong, Wen Jane Lee, Yi, Yu Chiao, Tien, Hsing Ru, Hung Chuan Pan, Meei Ling Sheu, Yu Chiao Yi, Sheu, Meei Ling, Hsing Ru Tien, Chen, Wen Bao, Maw Rong Lee, Wen Bao Chen, Lee, Wen Jane, Shen, Chin Chang, Jen Fon Jen, Liu, Shing Hwa, Yang, Tzung Jie, Chin Chang Shen, Jen, Jen Fon, Shing Hwa Liu   +22 more
core   +1 more source

-carboxymethyllysine, its precursor glyoxal and AGE-modified BSA on serotonin release from human parietal cells in culture

, 2018
Advanced glycation end products (AGEs) are frequently encountered in a western diet, in addition to their formation in vivo. N-Epsilon-carboxymethyllysine (CML), one of the chemically diverse compounds formed in the reaction between reducing ...
Holik, Ann-Katrin, Mark M. Somoza, Hölz, Kathrin, Ann-Katrin Holik, Kathrin Hölz, Veronika Somoza, Verena Stöger, Stöger, Verena, Somoza, Veronika, Somoza, Mark M.   +9 more
core   +1 more source

Formation of free and protein-bound carboxymethyllysine and carboxyethyllysine in meats during commercial sterilization

, 2016
The effect of commercial sterilization treatments on the levels of advanced glycation endproducts (AGEs) in meats was investigated. The amounts of both free and protein-bound N(ε)-carboxymethyllysine (CML) and N(ε)-carboxyethyllysine (CEL) in beef (rump,
Juming Tang, Xiaohua Sun, Yiqun Huang, Wang, Jing, Tang, Juming, Barbara A. Rasco, Rasco, Barbara A, Lai, Keqiang, Jing Wang, Keqiang Lai, Huang, Yiqun, Sun, Xiaohua   +11 more
core   +1 more source

Inhibition of Methylglyoxal-Induced Histone H1 N^ε‑Carboxymethyllysine Formation by (+)-Catechin

, 2018
Reactive dicarbonyl species (RCS) such as methylglyoxal (MGO) and glyoxal (GO) are common intermediates in protein damage, leading to the formation of advanced glycation end products (AGEs) through nonenzymatic glycation.
Cuixia Feng (5308367), Xinping Li (395794), Lijun Yang (356935), Zhaozhen Wu (5308370), Shaohua Dai (5308364), Qiang Dong (380835), Tianyu Zhang (188439)   +6 more
core   +1 more source