Results 91 to 100 of about 1,364 (167)

Serum carboxymethyllysine, an advanced glycation end product, and age-related macular degeneration: the Age, Gene/Environment Susceptibility-Reykjavik Study.

, 2014
IMPORTANCE Advanced glycation end products have been implicated in the pathogenesis of age-related macular degeneration (AMD). OBJECTIVE To investigate the relationship between serum carboxymethyllysine (CML), a major circulating advanced glycation end ...
Harris, Tamara B, Cotch, Mary Frances, Sun, Kai, Schaumberg, Debra A, Jonasson, Fridbert, Eiríksdottir, Gudny, Klein, Ronald, Gudnason, Vilmundur, Semba, Richard D, Ferrucci, Luigi   +9 more
core   +1 more source

Fecal excretion of Maillard reaction products and the gut microbiota composition of rats fed with bread crust or bread crumb

, 2017
A comparison between the impacts of advanced (Nε-carboxymethyllysine – CML) and terminal (melanoidins) Maillard reaction products from bread on gut microbiota was carried out in this study.
F. J. Tessier, C. Niquet-Léridon, M. Spatz, P. Gadonna-Widehem, P. M. Anton, C. Helou   +5 more
core   +1 more source

Peroxisome Proliferator-Activated Receptor‑γ Activators Monascin and Rosiglitazone Attenuate Carboxymethyllysine-Induced Fibrosis in Hepatic Stellate Cells through Regulating the Oxidative Stress Pathway but Independent of the Receptor for Advanced Glycation End Products Signaling

, 2016
Advanced glycation end products (AGEs) signaling through its receptors (RAGE) results in an increase in reactive oxygen species (ROS) and is thought to contribute to hepatic fibrosis via hyperglycemia.
Ya-Wen Hsu (398616), Wei-Hsuan Hsu (1793962), Tzu-Ming Pan (156183), Bao-Hong Lee (1793965)   +3 more
core   +1 more source

Quantitation of free glycation compounds in saliva.

PLoS ONE, 2019
In the course of the Maillard reaction, which occurs during heating of food but also under physiological condition, a broad spectrum of reaction products is formed.
Friederike Manig, Michael Hellwig, Franziska Pietz, Thomas Henle   +3 more
doaj   +1 more source

Effect of diabetes and aging on carboxymethyllysine levels in human urine

, 1991
Carboxymethyllysine (CML) has been identified as a modified amino acid that accumulates with age in human lens proteins and collagen. CML may be formed by oxidation of fructoselysine (FL), the Amadori adduct formed on nonenzymatic glycosylation of lysine
Dunn, J A, McCance, D R, Thorpe, S R, Baynes, J W, Lyons, T J, Knecht, K J, McFarland, K F   +6 more
core  

Comparative Study of the Effects of Dietary-Free and -Bound Nε-Carboxymethyllysine on Gut Microbiota and Intestinal Barrier

Nε-carboxymethyllysine (CML) is produced by a nonenzymatic reaction between reducing sugar and ε-amino group of lysine in food and exists as free and bound forms with varying digestibility and absorption properties in vivo, causing diverse interactions ...
Chenxi Nie (5600816), Zhifei Chen (1740625), Juxiu Li (5600825), Juan Liu (6492), Qingyu Ma (573061), Xiaojin Yuan (11607456), Min Zhang (111999), Chaoqi Wang (3045351), Huicui Liu (10162164)   +8 more
core   +1 more source

Nε-(carboxymethyl)lysine in blood from maintenance hemodialysis patients may contribute to dialysis-related amyloidosis

, 1998
Nε-(carboxymethyl)lysine in blood from maintenance hemodialysis patients may contribute to dialysis-related amyloidosis.BackgroundRecent studies demonstrated not only that advanced glycation end product could be found in amyloid tissue from patient with ...
Iwamoto, Hisahiko, Uchimura, Tomonori, Motomiya, Yoshihiro, Oyama, Nobuo, Maruyama, Ikuro   +4 more
core   +1 more source

Cross-sectional Analysis of AGE-CML, sRAGE, and esRAGE with Diabetes and Cardiometabolic Risk Factors in a Community-Based Cohort

, 2017
BACKGROUND Advanced glycation end products (AGEs) and their receptors are regarded as central to the development of diabetic complications, but associations with diabetes and cardiometabolic outcomes in previous studies are mixed.
Robert H Christenson, Casey M Rebholz, Eric S Christenson, Stephanie J Loomis, Elizabeth Selvin, Yuan Chen, David B Sacks   +6 more
core   +1 more source

Cuban Policosanol (Raydel^®) Exerts Higher Antioxidant and Anti-Glycation Activities than Chinese Policosanol (BOC Sciences) in Reconstituted High-Density Lipoproteins: In Vivo Anti-Inflammatory Activities in Zebrafish and Its Embryos

Pharmaceuticals
The present study compares sugarcane-wax purified policosanols sourced from Cuba (Raydel®) and China (BOC Sciences) and utilized following the synthesis of reconstituted high-density lipoproteins (rHDL).
Kyung-Hyun Cho, Ji-Eun Kim, Myeong-Sung Lee, Ashutosh Bahuguna   +3 more
doaj   +1 more source

Paradoxical impact of ntioxidants on post-amadori glycoxidation : counterintuitive increase in the yields of pentosidine and n{epsilon}-carboxymethyllysine using a novel multifunctional pyridoxamine derivative

, 2003
The inhibition of post-Amadori advanced glycation end product (AGE) formation by three different classes of AGE inhibitors, carbonyl group traps, chelators, and radical-trapping antioxidants, challenge the current paradigms that: 1) AGE inhibitors will ...
Ingold, Keith U., Morrison, Lisa D., Culbertson, Sean M., Vassilenko, Ekaterina I.   +3 more
core   +1 more source