Results 21 to 30 of about 127,833 (167)

Recapitulation of Clinical Individual Susceptibility to Drug-Induced QT Prolongation in Healthy Subjects Using iPSC-Derived Cardiomyocytes

Stem Cell Reports, 2017
To predict drug-induced serious adverse events (SAE) in clinical trials, a model using a panel of cells derived from human induced pluripotent stem cells (hiPSCs) of individuals with different susceptibilities could facilitate major advancements in ...
Tadahiro Shinozawa, Koki Nakamura, Masanobu Shoji, Maya Morita, Maya Kimura, Hatsue Furukawa, Hiroki Ueda, Masanari Shiramoto, Kyoko Matsuguma, Yoshikazu Kaji, Ippei Ikushima, Makoto Yono, Shyh-Yuh Liou, Hirofumi Nagai, Atsushi Nakanishi, Keiji Yamamoto, Seigo Izumo   +16 more
doaj   +1 more source

How to alleviate cardiac injury from electric shocks at the cellular level

Frontiers in Cardiovascular Medicine, 2022
Electric shocks, the only effective therapy for ventricular fibrillation, also electroporate cardiac cells and contribute to the high-mortality post-cardiac arrest syndrome.
Pamela W. Sowa, Pamela W. Sowa, Pamela W. Sowa, Aleksander S. Kiełbik, Aleksander S. Kiełbik, Andrei G. Pakhomov, Emily Gudvangen, Uma Mangalanathan, Volker Adams, Olga N. Pakhomova   +9 more
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Mechanotransduction regulates inflammation responses of epicardial adipocytes in cardiovascular diseases

Frontiers in Endocrinology, 2022
Adipose tissue is a crucial regulator in maintaining cardiovascular homeostasis by secreting various bioactive products to mediate the physiological function of the cardiovascular system.
Xiaoliang Liu, Lei Liu, Junfei Zhao, Hua Wang, Yifei Li   +4 more
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Atorvastatin alleviates cardiomyocyte apoptosis by suppressing TRB3 induced by acute myocardial infarction and hypoxia

Journal of the Formosan Medical Association, 2017
TRB3 (tribbles 3), an apoptosis-regulated gene, increases during endoplasmic reticulum stress. Hypoxia can induce inflammatory mediators and apoptosis in cardiomyocytes.
Wen-Pin Cheng, Huey-Ming Lo, Bao-Wei Wang, Su-Kiat Chua, Ming-Jen Lu, Kou-Gi Shyu   +5 more
doaj   +1 more source

Function of Adenylyl Cyclase in Heart: the AKAP Connection

Journal of Cardiovascular Development and Disease, 2018
Cyclic adenosine monophosphate (cAMP), synthesized by adenylyl cyclase (AC), is a universal second messenger that regulates various aspects of cardiac physiology from contraction rate to the initiation of cardioprotective stress response pathways.
Tanya A. Baldwin, Carmen W. Dessauer
doaj   +1 more source

Cardiomyocyte Maturation [PDF]

Circulation Research, 2020
Maturation is the last phase of heart development that prepares the organ for strong, efficient, and persistent pumping throughout the mammal’s lifespan. This process is characterized by structural, gene expression, metabolic, and functional specializations in cardiomyocytes as the heart transits from fetal to adult states.
Yuxuan Guo, William T. Pu
openaire   +2 more sources

Mini Review: the non-neuronal cardiac cholinergic system in type-2 diabetes mellitus

Frontiers in Cardiovascular Medicine
Diabetic heart disease remains the leading cause of death in individuals with type-2 diabetes mellitus (T2DM). Both insulin resistance and metabolic derangement, hallmark features of T2DM, develop early and progressively impair cardiovascular function ...
Eng Leng Saw, Martin Fronius, Rajesh Katare, Yoshihiko Kakinuma   +3 more
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Cardiomyocyte Inflammasome Signaling in Cardiomyopathies and Atrial Fibrillation: Mechanisms and Potential Therapeutic Implications

Frontiers in Physiology, 2018
Inflammasomes are high molecular weight protein complexes in the cytosol of immune and other cells that play a critical role in the innate immune system in response to cellular stress.
Gong Chen, Mihail G. Chelu, Mihail G. Chelu, Dobromir Dobrev, Na Li, Na Li, Na Li   +6 more
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The role of amino acid arginine and nitric oxide system in implementing cardioprotective effect of non-opioid analogue of leu-enkephalin in newborn albino rats after intrauterine hypoxia

Russian Open Medical Journal, 2020
Objective ― to evaluate the role of the amino acid arginine in the structure of the non-opioid analogue of leu-enkephalin (NALE) and the involvement of the nitric oxide system in the implementation of its cardioprotective effect in newborn albino rats ...
Elena N. Sazonova, Olga А. Lebed'ko, Natalya A. Tsymbalist, Ilya A. Gusev, Elena Yu. Samarina, Yulia B. Malofey   +5 more
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A New Role for Extracellular Vesicles in Cardiac Tissue Engineering and Regenerative Medicine

Advanced NanoBiomed Research, 2021
Cardiovascular diseases are the leading cause of death worldwide. Discovering new therapies to treat heart disease requires improved understanding of cardiac physiology at a cellular level. Extracellular vesicles (EVs) are plasma membrane‐bound nano‐ and
Karl T. Wagner, Milica Radisic
doaj   +1 more source