Results 41 to 50 of about 127,833 (167)

Bioengineering Approaches to Mature Human Pluripotent Stem Cell-Derived Cardiomyocytes

Frontiers in Cell and Developmental Biology, 2017
Human pluripotent stem cell-derived cardiomyocytes (hPSC-CM) represent a potential unlimited cell supply for cardiac tissue engineering and possibly regenerative medicine applications.
Xuetao Sun, Sara S. Nunes, Sara S. Nunes, Sara S. Nunes   +3 more
doaj   +1 more source

Cre-loxP-mediated genetic lineage tracing: Unraveling cell fate and origin in the developing heart

Frontiers in Cardiovascular Medicine, 2023
The Cre-loxP-mediated genetic lineage tracing system is essential for constructing the fate mapping of single-cell progeny or cell populations. Understanding the structural hierarchy of cardiac progenitor cells facilitates unraveling cell fate and origin
Tao Wang, Xinzhe Chen, Kai Wang, Jie Ju, Xue Yu, Shaocong Wang, Cuiyun Liu, Kun Wang   +7 more
doaj   +1 more source

Transplantation of cryopreserved cardiomyocytes [PDF]

The Journal of Thoracic and Cardiovascular Surgery, 2001
The present study examined the survival and rate of contraction of (1) cardiomyocytes cultured from cryopreserved fetal rat myocardium and (2) cryopreserved cultured cardiomyocytes. In addition, the effects of transplantation of cryopreserved fetal cardiomyocytes were evaluated.Segments of fetal rat myocardial tissue (0.2, 2.0, and 6.0 mm(3) mince size)
Yokomuro, Hiroki, Li, Ren-Ke, Mickle, Donald A.G., Weisel, Richard D., Verma, Subodh, Yau, Terrence M.   +5 more
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Reprogramming Fibroblasts into Cardiomyocytes [PDF]

New England Journal of Medicine, 2011
The transdifferentiation of one differentiated cell type into another is the focus of much research activity. A recent study shows that mouse fibroblasts can be transdifferentiated, albeit with low efficiency, into cardiomyocytes.
Charles E, Murry, William T, Pu
openaire   +2 more sources

Sgk1-Dependent Stimulation of Cardiac Na+/H+ Exchanger Nhe1 by Dexamethasone

Cellular Physiology and Biochemistry, 2013
Background/Aims: The serum- and glucocorticoid-inducible kinase Sgk1 contributes to cardiac remodeling and development of heart failure, which is paralelled by Sgk1-dependent stimulation of the cardiac Na+/H+ exchanger Nhe1.
Jakob Voelkl, Venkanna Pasham, Mohamed Siyabeldin E. Ahmed, Britta Walker, Kalina Szteyn, Dietmar Kuhl, Bernhard Metzler, Ioana Alesutan, Florian Lang   +8 more
doaj   +1 more source

Myocardin Induces Cardiomyocyte Hypertrophy [PDF]

Circulation Research, 2006
In response to stress signals, postnatal cardiomyocytes undergo hypertrophic growth accompanied by activation of a fetal gene program, assembly of sarcomeres, and cellular enlargement. We show that hypertrophic signals stimulate the expression and transcriptional activity of myocardin, a cardiac and smooth muscle–specific coactivator of serum response ...
Weibing, Xing, Tong-Cun, Zhang, Dongsun, Cao, Zhigao, Wang, Christopher L, Antos, Shijie, Li, Yibin, Wang, Eric N, Olson, Da-Zhi, Wang   +8 more
openaire   +2 more sources

MicroRNA-Mediated Direct Reprogramming of Human Adult Fibroblasts Toward Cardiac Phenotype

Frontiers in Bioengineering and Biotechnology, 2020
Modulation of microRNA expression holds the promise to achieve direct reprogramming of fibroblasts into cardiomyocyte-like cells as a new strategy for myocardial regeneration after ischemic heart disease.
C. Paoletti, C. Divieto, G. Tarricone, F. Di Meglio, D. Nurzynska, V. Chiono   +5 more
doaj   +1 more source

Cardiomyocyte Cell Cycle Regulation [PDF]

Circulation Research, 2002
Although rapid progress is being made in many areas of molecular cardiology, issues pertaining to the origins of heart-forming cells, the mechanisms responsible for cardiogenic induction, and the pathways that regulate cardiomyocyte proliferation during embryonic and adult life remain unanswered.
Kishore B S, Pasumarthi, Loren J, Field
openaire   +2 more sources

NAD⁺-Dependent Lysine Acetylation Regulates Glucose Uptake and Fatty Acid Oxidation in Cardiomyocytes

Metabolites
Background/Objectives: Stimulation of glucose uptake in response to ischemic stress is important for cardiomyocyte post-ischemic function and survival. In the diabetic myocardium chronically exposed to an excess of circulating lipids, this mechanism is ...
Ettore Vanni, Christophe Montessuit
doaj   +1 more source

Experimental ‏review ‏of ‏cobalt ‏induced cardiomyopathy

Russian Open Medical Journal, 2017
The heart is a target of injury for many chemical compounds, both medically prescribed and not. Pathophysiological mechanisms underlying development of chemical-induced cardiomyopathies vary depending on the inciting agent, and can include: direct toxic ...
Igor ‏V. Zadnipryany, Olga ‏S. Tretiakova, Tatiana P. Sataieva, Walery ‏Zukow   +3 more
doaj   +1 more source