Results 81 to 90 of about 231,805 (310)
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021 Background We determined if the sodium glucose co‐transporter 2 inhibitor empagliflozin attenuates pressure overload‐induced heart failure in non‐diabetic mellitus mice by direct cardiac effects and the mechanisms involved. Methods and Results Male C57BL/
Xuan Li +10 more
doaj +1 more source
Regulated Inositol‐Requiring Protein 1‐Dependent Decay as a Mechanism of Corin RNA and Protein Deficiency in Advanced Human Systolic Heart Failure [PDF]
, 2014 BACKGROUND: The compensatory actions of the endogenous natriuretic peptide system require adequate processing of natriuretic peptide pro‐hormones into biologically active, carboxyl‐terminal fragments.
Barton, P +5 more
core +1 more source
Myocardin Induces Cardiomyocyte Hypertrophy [PDF]
Circulation Research, 2006 In response to stress signals, postnatal cardiomyocytes undergo hypertrophic growth accompanied by activation of a fetal gene program, assembly of sarcomeres, and cellular enlargement. We show that hypertrophic signals stimulate the expression and transcriptional activity of myocardin, a cardiac and smooth muscle–specific coactivator of serum response ...
Weibing, Xing +8 more
openaire +2 more sources
Smart Catheters for Diagnosis, Monitoring, and Therapy
Advanced Healthcare Materials, EarlyView.This study presents a comprehensive review of smart catheters, an emerging class of medical devices that integrate embedded sensors, robotics, and communication systems, offering increased functionality and complexity to enable real‐time health monitoring, diagnostics, and treatment. Abstract This review explores smart catheters as an emerging class of
Azra Yaprak Tarman +12 more
wiley +1 more source
MetabolitesBackground/Objectives: Stimulation of glucose uptake in response to ischemic stress is important for cardiomyocyte post-ischemic function and survival. In the diabetic myocardium chronically exposed to an excess of circulating lipids, this mechanism is ...
Ettore Vanni, Christophe Montessuit
doaj +1 more source
Experimental review of cobalt induced cardiomyopathy
Russian Open Medical Journal, 2017 The heart is a target of injury for many chemical compounds, both medically prescribed and not. Pathophysiological mechanisms underlying development of chemical-induced cardiomyopathies vary depending on the inciting agent, and can include: direct toxic ...
Igor V. Zadnipryany +3 more
doaj +1 more source
Frontiers in Bioengineering and Biotechnology, 2020 Cardiovascular diseases represent the major cause of morbidity and mortality worldwide. Multiple studies have been conducted so far in order to develop treatments able to prevent the progression of these pathologies.
Marta Mazzola +2 more
doaj +1 more source
IL-1α and TNF-α Down-Regulate CRH Receptor-2 mRNA Expression in the Mouse Heart [PDF]
, 2001 Two receptors (CRH receptor type 1 and CRH receptor type 2) have been identified for the stress-induced neuropeptide, CRH and related peptides, urocortin, and urocortin II.
Coste, Sarah C. +4 more
core +2 more sources
Cardiomyocyte Cell Cycle Regulation [PDF]
Circulation Research, 2002 Although rapid progress is being made in many areas of molecular cardiology, issues pertaining to the origins of heart-forming cells, the mechanisms responsible for cardiogenic induction, and the pathways that regulate cardiomyocyte proliferation during embryonic and adult life remain unanswered.
Kishore B S, Pasumarthi, Loren J, Field
openaire +2 more sources
Advanced Healthcare Materials, EarlyView.Patient‐derived cardiac organoids reveal key features of Duchenne muscular dystrophy cardiomyopathy, including apoptosis, oxidative stress, calcium handling defects, and mechanical remodeling. By integrating organoids into alginate–gelatin bioprinted constructs, disease phenotypes are organized into scalable 3D cardiac tissues displaying extracellular ...
Vittoria Marini +15 more
wiley +1 more source