Results 11 to 20 of about 4,015,701 (290)

Noncanonical inflammasomes: caspase-11 activation and effector mechanisms. [PDF]

PLoS Pathogens, 2013
Inflammasomes are cytosolic, multiprotein complexes assembled by members of the NOD-like receptor (NLR) and PYHIN protein families in response to pathogen-associated molecular patterns (PAMPs) and danger signals, and serve as activation platforms for ...
Petr Broz, Denise M Monack
doaj   +9 more sources

Roles of the Caspase-11 Non-Canonical Inflammasome in Rheumatic Diseases. [PDF]

Int J Mol Sci
Inflammasomes are intracellular multiprotein complexes that activate inflammatory signaling pathways. Inflammasomes comprise two major classes: canonical inflammasomes, which were discovered first and are activated in response to a variety of pathogen ...
Yi YS.
europepmc   +4 more sources

Caspase-11 Non-canonical Inflammasomes in the Lung [PDF]

Frontiers in Immunology, 2020
The airway epithelium and underlying innate immune cells comprise the first line of host defense in the lung. They recognize pathogen-associated molecular patterns (PAMPs) using membrane-bound receptors, as well as cytosolic receptors such as ...
Changhoon Oh, Ambika Verma, Youssef Aachoui   +2 more
doaj   +5 more sources

Regulation, Activation and Function of Caspase-11 during Health and Disease. [PDF]

Int J Mol Sci, 2021
Caspase-11 is a pro-inflammatory enzyme that is stringently regulated during its expression and activation. As caspase-11 is not constitutively expressed in cells, it requires a priming step for its upregulation, which occurs following the stimulation of
Agnew A, Nulty C, Creagh EM.
europepmc   +5 more sources

Caspase-11 promotes allergic airway inflammation [PDF]

Nature Communications, 2020
Caspase 11 activation involves transcriptional upregulation and proteolytic cleavage. Here the authors show that prostaglandin E2 prevents caspase-11-mediated pyroptosis, blocking caspase-11 mRNA and protein upregulation in macrophages and in vivo, and ...
Zbigniew Zasłona, Ewelina Flis, Mieszko M. Wilk, Richard G. Carroll, Eva M. Palsson-McDermott, Mark M. Hughes, Ciana Diskin, Kathy Banahan, Dylan G. Ryan, Alexander Hooftman, Alicja Misiak, Jay Kearney, Gunter Lochnit, Wilhelm Bertrams, Timm Greulich, Bernd Schmeck, Oliver J. McElvaney, Kingston H. G. Mills, Ed C. Lavelle, Małgorzata Wygrecka, Emma M. Creagh, Luke A. J. O’Neill   +21 more
doaj   +5 more sources

Caspase-11/GSDMD contributes to the progression of hyperuricemic nephropathy by promoting NETs formation. [PDF]

Cell Mol Life Sci
Hyperuricemia is an independent risk factor for chronic kidney disease (CKD) and promotes renal fibrosis, but the underlying mechanism remains largely unknown.
Wu F, Chen C, Lin G, Wu C, Xie J, Lin K, Dai X, Chen Z, Ye K, Yuan Y, Chen Z, Ma H, Lin Z, Xu Y.   +13 more
europepmc   +2 more sources

Quercetin Ameliorates Acute Lethal Sepsis in Mice by Inhibiting Caspase-11 Noncanonical Inflammasome in Macrophages. [PDF]

Molecules
Quercetin is a natural polyphenolic flavonoid widely found in plants, fruits, and vegetables, and has been reported to play pharmacological roles in numerous pathogenic conditions.
Kim E, Choi DH, Yi YS.
europepmc   +2 more sources

Ganglioside GA2-mediated caspase-11 activation drives macrophage pyroptosis aggravating intimal hyperplasia after arterial injury. [PDF]

Int J Biol Sci
Intimal hyperplasia (IH) remains a significant clinical problem, causing vascular intervention failure. This study aimed to elucidate whether gangliosides GA2 accumulated in atherosclerotic mouse aortae and plasma promote the development of IH.
Shi Y, He T, Liu H, Li X, Li Z, Wen Q, Dai Z, Sun X, Tan Q, Yang W, Jiang Y, Liu Y, Yuan H, Lei F, Yi Y, Cai J.   +15 more
europepmc   +2 more sources

Adipose tissue IL‐18 production is independent of caspase‐1 and caspase‐11 [PDF]

Immunity, Inflammation and Disease
Background Inflammation in adipose tissue, resulting from imbalanced caloric intake and energy expenditure, contributes to the metabolic dysregulation observed in obesity.
Luis Román‐Domínguez, Jonathan Salazar‐León, Karla F. Meza‐Sosa, Leonor Pérez‐Martínez, Gustavo Pedraza‐Alva   +4 more
doaj   +2 more sources

Dectin-1 aggravates neutrophil inflammation through caspase-11/4-mediated macrophage pyroptosis in asthma. [PDF]

Respir Res
Background The pattern recognition receptor Dectin-1 was initially discovered to play a pivotal role in mediating pulmonary antifungal immunity and promoting neutrophil-driven inflammation.
Cai R, Gong X, Li X, Jiang Y, Deng S, Tang J, Ge H, Wu C, Tang H, Wang G, Xie L, Chen X, Hu X, Feng J.   +13 more
europepmc   +2 more sources