Results 131 to 140 of about 332,821 (272)

Caspase-8 levels correlate with the expression of signal transducer and activator of transcription 1 in high-grade but not lower grade neuroblastoma

, 2006
BACKGROUND: Previous studies in advanced-stage neuroblastoma (NB) have shown a link between the silencing of caspase-8 and methylation of a regulatory region at the boundary between caspase-8 exon 3 and intron 3.
A Muscat (14461452), C Hawkins (9874637), DM Ashley (14452374)   +2 more
core  

Indução de apoptose e ativação de caspase por chalconas em linhagem celular de leucemia: relação entre estresse oxidativo e morte celular [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2010O câncer corresponde a um grupo de doenças que possuem em comum o descontrole na proliferação.
Silva, Evelyn Winter da
core  

NF-κB inhibition down-regulates the expression of caspase-4.

, 2015
(A) SH-EP1 cells transfected with control vector (Ctl) or DN-IκBα expression vector (DN-IκBα) were lysed, and the expression levels of various caspases were detected using corresponding antibodies.
Xiao-Yu Lin (693877), Lei Wang (6656), Mian Wang (153332), Bin-Feng Cheng (693876), Zhi-Wei Feng (693878), Hai-Jie Yang (693875)   +5 more
core   +1 more source

Dual‐Responsive Dynamic Covalent Bond‐Based Assembly of Lipid‐Nanozyme Systems via Multi‐Target Synergy and Efficient Target Enrichment for Ischemic Stroke Therapy

Advanced Science, EarlyView.
This system adopts a biomimetic phospholipid structure, covalently binding iNOS inhibitors, neuroprotective agent PCA and vitamin E derivatives through pH/ROS dual‐responsive bonds, and assembles them with Prussian blue nanozyme to form PBB@AHA. It can efficiently penetrate the blood‐brain barrier and simultaneously release multiple active components ...
Mengcheng Guo, Qingran Guan, Guanyu Qiao, Lixue Zhang, Man Liu, Zhen Li, Qingbiao Yang, Meili Shen, Linlin Liu, Yapeng Li   +9 more
wiley   +1 more source

The role of caspase-1, caspase-4, NLRP3 and IL-1RA in bladder epithelial cells infected by uropathogenic Escherichia coli

, 2023
Urinary tract infection is one of the most common infections and is mostlycaused by uropathogenic Escherichia coli (UPEC). The inflammasomeassociatedproteins caspase-1, caspase-4 and NLRP3 are essential in the hostcell response during urinary tract ...
Lindblad, Anna
core   +1 more source

Die Rolle der Caspase-4 und -5 in renalen Schädigungsmodellen

, 2021
Hintergrund und Ziele: Die murine Caspase-11 und ihre humanen Gegenstücke, Caspase-4 und -5, sind bei Entzündungsreaktionen an der Regulation von Zelluntergang und damit verbunden an der Freisetzung von Interleukin-1a beteiligt.
Göth, Daniel
core  

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

Microbial sensing through the non-canonical inflammasome modulates airway type 2 immunity

Frontiers in Immunology
IntroductionAirway epithelial cells serve as critical sensors of both microbes and allergens, orchestrating immune responses through damage-associated molecular patterns including IL-33.
Olivier Bernard, Sheyla Yamato, Oluwaferanmi Bello, Raquel Alvarez, Carter J. Supple, Louis Z. Sharp, Jahanvi Kumar, Maya E. Kotas, Erin D. Gordon   +8 more
doaj   +1 more source

African swine fever virus infection regulates pyroptosis by cleaving gasdermin A via active caspase-3 and caspase-4

Journal of Biological Chemistry
African swine fever, caused by the African swine fever virus (ASFV), is a viral hemorrhagic disease that affects domestic pigs and wild boars. ASFV infection causes extensive tissue damage, and the associated mechanism is poorly understood. Pyroptosis is characterized by the activation of inflammatory caspases and pore formation in the cellular plasma ...
Li, Shuai, Song, Jie, Liu, Jia, Zhou, Shijun, Zhao, Gaihong, Li, Tingting, Huang, Li, Li, Jiangnan, Weng, Changjiang   +8 more
openaire   +2 more sources

PSMA8‐Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility

Advanced Science, EarlyView.
PSMA8 assembles s20S proteasome that degrades specific substrates in elongating spermatids. Degradation of s20S‐substrates activates translation of FXR1‐target mRNAs, which are essential for mitochondrial sheath formation and sperm morphogenesis.
Huiwen Cao, Qianting Zhang, Wei Xu, Anxuan Fang, Haomang Xu, Cheng Qiu, Lugeng He, Chao Yu   +7 more
wiley   +1 more source