Results 111 to 120 of about 332,821 (272)

Inhibitors of Caspase-1, Caspase-3, Caspase-6 and Caspase-8 block silica-induced pyroptosis.

, 2022
Related to Fig 4. a, Images and cell viability of WT, Nlrp3-/-, Caspase-1-/-, Gsdmd-/-, Gsdme-/- and Gsdmd-/-Gsdme-/- BMDMs pretreated with the indicated caspase inhibitors and stimulated with silica. Arrowheads indicate pyroptotic cells.
Yujie Zou (408340), Yaqiong Tian (6309854), Peiliang Shi (2617767), Lulu Kang (684986), Ji Zhang (70438), Visarut Codey Buranasudja (14209915), Jinghong Dai (13848544), Jingwen Pei (5626415), Xiang Gao (4077), Hourong Cai (6309875), Zhaoyu Lin (170763), Yufang Wang (105742), Jingyu Chen (3571688)   +12 more
core   +1 more source

Self‐Assembled Skin Equivalents with Monoclonal CRISPR/Cas9‐Modified N/TERT‐1 Keratinocytes: A Cutting‐Edge model for Human Skin and its Diseases

Advanced Healthcare Materials, EarlyView.
Self‐assembled, scaffold‐free full‐thickness skin equivalents with monoclonal, genetically modified N/TERT‐1 keratinocytes represent a novel in vitro model of human skin and skin diseases. The model is highly robust, reproducible, physiologically relevant, and suitable for high‐throughput applications.
Marta Slaufova, Tugay Karakaya, Michela Di Filippo, Thomas Kündig, Hans‐Dietmar Beer   +4 more
wiley   +1 more source

Autophagy occurs upstream or parallel to the apoptosome during histolytic cell death

, 2006
Histolysis refers to a widespread disintegration of tissues that is morphologically distinct from apoptosis and often associated with the stimulation of autophagy. Here, we establish that a component of the apoptosome, and pivotal regulator of apoptosis,
Xiaodong Wang, John M. Abrams, Suganthi Chittaranjan, Gorski, Sharon M., Antony Rodriguez, Medved'ova, L, Wang, Xd, Rodriguez, Antony, Akdemir, Fatih, Farkas, Robert, Sharon M. Gorski, Lai Wang, Medved'ová, Lucia, Abrams, John M., Wang, Xiaodong, Sass, Miklós, Gabor Juhasz, Chittaranjan, Suganthi, Robert Farkaš, Abrams, Jm, Po Chen, Miklos Sass, Fatih Akdemir, Chen, Po, Lucia Medved'ová, Gorski, Sm, Juhász, Gábor, Wang, Lai   +27 more
core   +1 more source

Predicated cleavage site for caspase-4 on GSDMD.

, 2022
The molecular weight of full length rGSDMD is 81 kDa as a GST tag is linked to NT of rGSDMD, whereas CT is tagged by His. (A) Cleavage of 5 μg purified recombinant GSDMD with 6U recombinant caspase-4 visualized by Coomassie blue staining of the protein ...
Kris Chadee (249039), France Moreau (458493), Shanshan Wang (283009)   +2 more
core   +1 more source

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal, Milan Patra, Rianita Mondal, Shubhasis Haldar   +3 more
wiley   +1 more source

GPR124 Alleviates Blood–Brain Barrier Disruption by Enhancing Microvascular Endothelial Function after Traumatic Brain Injury

Advanced Science, EarlyView.
Our study reveals the protective role of GPR124 in maintaining BBB integrity and promoting neurological recovery following TBI. It makes a significant contribution by uncovering a novel molecular interaction between GPR124 and FGFBP1 and linking this to activation of the Wnt/β‐catenin signaling pathway in vascular repair mechanisms.
Chen Wang, Lin Cai, Qiuyuan Gong, Yang Yang, Yuqing Liang, Xinyu Niu, Lai Wei, Ze Liu, Shengju Wu, Yinghui Men, Yaohui Tang, Jun Ding, Hengli Tian, Hao Chen   +13 more
wiley   +1 more source

Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome

Cell Reports, 2018
Summary: The non-canonical caspase-4 and canonical NLRP3 inflammasomes are both activated by intracellular lipopolysaccharide (LPS), but the crosstalk between these two pathways remains unclear.
Jaye M. Platnich, Hyunjae Chung, Arthur Lau, Christina F. Sandall, Adom Bondzi-Simpson, Huey-Miin Chen, Takanori Komada, Aaron C. Trotman-Grant, Jeremy R. Brandelli, Justin Chun, Paul L. Beck, Dana J. Philpott, Stephen E. Girardin, May Ho, Roger P. Johnson, Justin A. MacDonald, Glen D. Armstrong, Daniel A. Muruve   +17 more
doaj   +1 more source

Berberine induces caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factor

, 2011
Berberine, an isoquinoline alkaloid derived from plants, is a traditional medicine for treating bacterial diarrhea and intestinal parasite infections. Although berberine has recently been shown to suppress growth of several tumor cell lines, information ...
Tianhui Hu, Rupesh Chaturvedi, Yan Shi, Hamwei Cao, Fang Yan, Lihong Wang, Liping Liu, Keith Wilson, D. Brent Polk   +8 more
core  

Caspase-11, NLRP3 and type IV secretion system are critical to IL-1β secretion and caspase-1 activation in response to B. abortus.

, 2019
BMDMs obtained from C57BL/6, Casp11−/−, Casp1−/−Casp11Tg, Nlrp3−/− and Casp1/11−/− mice were primed with E. coli LPS (1 μg/ml) for 4 h and then left uninfected (NI) or stimulated with B. abortus or mutant virB2. BMDMs were infected with B.
Daiane M. Cerqueira (4329529), Dario S. Zamboni (192409), Alexandre L. N. Silva (284119), Erika S. Guimarães (5363321), Sergio C. Oliveira (212251), Marcella Rungue (6160733), Natan R. G. Assis (540086), Suellen B. Morais (540084), Marco Túlio R. Gomes (5363324), Petr Broz (383934)   +9 more
core   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source