Results 101 to 110 of about 332,821 (272)
Caspase-8 catalytic activity is required for maximal TLR-induced cytokine production.
, 2016 (A-F) Indicated BMDMs were pretreated with the pan-caspase inhibitor zVAD-fmk (A-C), QVD-oph (D) or IETD-fmk (F) for 1hr prior to 6 hr stimulation with LPS (100 ng/mL).
Melanie Santos-Marrero (3217635) +16 more
core +1 more source
Advanced Engineering Materials, EarlyView.Selenium was incorporated into a sol–gel‐derived bioactive glass to enable sustained therapeutic ion release. The selenium‐containing glass preserved bioactivity while selectively inducing cytotoxicity in osteosarcoma cells and maintaining osteoblastic viability.
Breno Rocha Barrioni +7 more
wiley +1 more source
Mechanoluminescent HOF Nanotransducers Enabled Sono‐Optogenetics in Parkinsonian Rats
Advanced Functional Materials, EarlyView.We present a mechanoluminescent system utilizing porous hydrogen‐bonded organic frameworks (HOFs) as a toolkit for focused ultrasound‐triggered, non‐invasive light delivery to the deep brain in rats. This approach enables the specific activation of PV‐GPe neurons in dopamine‐depleted Parkinson's disease rat models, resulting in a comparable alleviation
Wenliang Wang +18 more
wiley +1 more source
TNFA deletion alters apoptosis as well as caspase 3 and 4 expression during otitis media
BMC Immunology, 2011 Background Tumor necrosis factor (TNFA) is the canonical member of the TNF superfamily, which plays a major role in both inflammation and apoptosis. To evaluate the role of TNFs in otitis media (OM), the most common disease of childhood, we evaluated ...
Broide David +9 more
doaj +1 more source
, 2008 Background: The BH3-only protein Bid is an important component of death receptor-mediated caspase activation. Bid is cleaved by caspase-8 or -10 into t-Bid, which translocates to mitochondria and triggers the release of caspase-activating factors.
Caoimhin G Concannon +17 more
core +1 more source
Advanced Functional Materials, EarlyView.We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins +9 more
wiley +1 more source
E. histolytica activates caspase-4 and caspase-1 in a time-dependent manner.
, 2022 The kinetics of Eh-induced caspase-4 activation was detected by incubating PMA-differentiated THP-1 macrophages for increasing amounts of time with 1:20 Eh to macrophage ratio. (A) Macrophages were incubated for increasing amounts of time with 1:20 Eh to
Kris Chadee (249039) +2 more
core +1 more source
Advanced Healthcare Materials, EarlyView.Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim +5 more
wiley +1 more source
Journal of Lipid Research, 2006 Two splice variants are derived from the caspase-9 gene, proapoptotic caspase-9a and antiapoptotic caspase-9b, by either the inclusion or exclusion of an exon 3, 4, 5, and 6 cassette.
Autumn Massiello, Charles E. Chalfant
doaj +1 more source
Caspase-3-Responsive, Fluorogenic Bivalent Bottlebrush Polymers
Controlling the access of proteases to cleavable peptides placed at specific locations within macromolecular architectures represents a powerful strategy for biologically responsive materials design.
Bin Liu (5899) +3 more
core +1 more source