Altered expression of caspases-4 and -5 during inflammatory bowel disease and colorectal cancer : diagnostic and therapeutic potential [PDF]
, 2015 Caspases are a group of proteolytic enzymes involved in the co-ordination of cellular processes, including cellular homeostasis, inflammation and apoptosis.
Caiazza, F +12 more
core +2 more sources
mSystems, 2021 Macrophages and monocytes are innate immune cells playing an important role in orchestrating the initial innate immune response to bacterial infection and the tissue damage.
Orna Ernst +11 more
doaj +1 more source
Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death [PDF]
, 2016 Sensing bacterial products in the cytosol of mammalian cells by NOD-like receptors leads to the activation of caspase-1 inflammasomes, and the production of the pro-inflammatory cytokines interleukin (IL)-18 and IL-1β.
Alix, E +7 more
core +1 more source
TRAIL, DR5 and Caspase 3-dependent Apoptosis in Vessels of Diseased Human Temporomandibular Joint Disc. An Immunohistochemical Study [PDF]
, 2010 To evaluate the apoptosis involvement in the angiogenesis as a self-limiting process in patients with temporomandibular joint (TMJ) degenerated disc vessels, we assessed, by immunohistochemistry, the detection of TRAIL, its death receptor DR5 and caspase
Almeida, Luis Eduardo +4 more
core +4 more sources
NF-κB regulates caspase-4 expression and sensitizes neuroblastoma cells to Fas-induced apoptosis. [PDF]
PLoS ONE, 2015 Found in neurons and neuroblastoma cells, Fas-induced apoptosis and accompanied activation of NF-κB signaling were thought to be associated with neurodegenerative diseases. However, the detailed functions of NF-κB activation in Fas killing and the effect
Hai-Jie Yang +5 more
doaj +1 more source
Cleaved Caspase-3 Sebagai Uji Apoptosis Pada Kanker Serviks IIB Tipe Sel Skuamosa Yang Mendapat Kemoterapi Neoadjuvan Cisplatin [PDF]
, 2015 Tujuan: mencari peningkatan ekspresi cleaved caspase-3 pada pasien kanker serviks IIB tipe sel skuamosa sesudah pemberian kemoterapi neoadjuvan cisplatin dan mencari kapan waktu yang tepat untuk mendeteksi apoptosis menggunakan cleaved caspase-3.
Askandar, B. (Brahmana) +2 more
core +2 more sources
Function of BID - a molecule of the bcl-2 family - in ischemic cell death in the brain [PDF]
, 2002 Mitochondrial mechanisms, particularly the release of cytochrome c, play a role in the death of nerve and glial cells in cerebral ischemia. We have currently investigated whether BID, a proapoptotic molecule of the bcl-2 family and promoter of the ...
Amin-Hanjani, Sepideh +5 more
core +1 more source
Protective role of Cop in Rip2/Caspase-1/Caspase-4-mediated HeLa cell death
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2006 CARD only protein (Cop) was recently identified as a protein with significant homology with the CARD of caspase-1. We have conducted functional studies on Cop and report on its role as an inhibitor of cell death in a broad range of cell death paradigms. A notable exception in the ability of Cop to inhibit cell death pertains to its inability to inhibit
X. Wang +6 more
openaire +2 more sources
A Critical Role for Human Caspase-4 in Endotoxin Sensitivity [PDF]
The Journal of Immunology, 2014 Abstract Response to endotoxins is an important part of the organismal reaction to Gram-negative bacteria and plays a critical role in sepsis and septic shock, as well as other conditions such as metabolic endotoxemia. Humans are generally more sensitive to endotoxins when compared with experimental animals such as mice.
Yuji, Kajiwara +6 more
openaire +2 more sources
Saturated free fatty acids and apoptosis in microvascular mesangial cells: palmitate activates pro-apoptotic signaling involving caspase 9 and mitochondrial release of endonuclease G [PDF]
, 2005 BACKGROUND: In type 2 diabetes, free fatty acids (FFA) accumulate in microvascular cells, but the phenotypic consequences of FFA accumulation in the microvasculature are incompletely understood. Here we investigated whether saturated FFA induce apoptosis
Mishra, Rangnath, Simonson, Michael S
core +3 more sources