Results 31 to 40 of about 332,821 (272)
Frontiers in Genetics, 2021 The dysregulation of caspase 4 (CASP4) expression is related to the occurrence, development, and outcome of many malignant tumors; however, its role in clear cell renal cell carcinoma (ccRCC) remains unclear.
Lingfeng Meng +12 more
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Frontiers in Immunology, 2023 IntroductionHuman adenovirus (HAdV) is a common respiratory virus, which can lead to severe pneumonia in children and immunocompromised persons, and canonical inflammasomes are reported to be involved in anti-HAdV defense.
Lexi Li +9 more
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Pyroptosis: A Common Feature of Immune Cells of Haemodialysis Patients
Toxins, 2021 NLRP-3 inflammasome activation can result in interleukin-1β (IL-1β) release and inflammatory cell death (pyroptosis). Caspase-1 is able to trigger both processes.
Christof Ulrich +10 more
doaj +1 more source
Caspase-12 and Caspase-4 Are Not Required for Caspase-dependent Endoplasmic Reticulum Stress-induced Apoptosis [PDF]
Journal of Biological Chemistry, 2005 Alterations in cellular homeostasis that affect protein folding in the endoplasmic reticulum (ER) trigger a signaling pathway known as the unfolded protein response (UPR). The initially cytoprotective UPR will trigger an apoptotic cascade if the cellular insult is not corrected; however, the proteins required to initiate this cell death pathway are ...
Esther A, Obeng, Lawrence H, Boise
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Increased expression of caspase 1 during active phase of connective tissue disease [PDF]
PeerJ, 2019 Key factors of pyroptosis play an important role in the inflammatory response to connective tissue disease (CTD). However, information on active and stable stages of CTD is scarce.
Rentian Cai +4 more
doaj +2 more sources
Caspase-dependent apoptosis by ectopic expression of E2F-4 [PDF]
Oncogene, 2000 E2F is a family of transcription factors which regulates cell cycle and apoptosis of mammalian cells. E2F-1-3 localize in the nucleus, and preferentially bind pRb, while E2F-4 and 5 have no nuclear localization signal and preferentially bind p107/p130. E2F-6 suppresses the transcriptional activity of other E2F proteins.
Y C, Chang +12 more
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A Critical Role for Human Caspase-4 in Endotoxin Sensitivity [PDF]
The Journal of Immunology, 2014 Abstract Response to endotoxins is an important part of the organismal reaction to Gram-negative bacteria and plays a critical role in sepsis and septic shock, as well as other conditions such as metabolic endotoxemia. Humans are generally more sensitive to endotoxins when compared with experimental animals such as mice.
Yuji, Kajiwara +6 more
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Talaromyces marneffei activates the AIM2-caspase-1/-4-GSDMD axis to induce pyroptosis in hepatocytes
, 2022 Talaromyces marneffei tends to induce systemic infection in immunocompromised individuals, which is one of the causes of the high mortality. The underlying molecular mechanisms of T.marneffei-induced abnormal liver function are still poorly understood ...
Zhang, Peng +31 more
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Caspase-4 and -5 expression in HIOs and inhibition.
, 2022 A. Western blot measuring Caspase-4 levels in HIO lysates microinjected with PBS or STM. Blot was probed for Actin as a loading control. B. Western blot measuring Caspase-5 levels in HIO lysates that were microinjected with PBS or STM. Lysates from human
David R. Hill (2330602) +13 more
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Spotlight on pyroptosis: role in pathogenesis and therapeutic potential of ocular diseases
Journal of Neuroinflammation, 2022 Pyroptosis is a programmed cell death characterized by swift plasma membrane disruption and subsequent release of cellular contents and pro-inflammatory mediators (cytokines), including IL‐1β and IL‐18.
Meini Chen, Rong Rong, Xiaobo Xia
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