Results 11 to 20 of about 332,821 (272)

Caspase-4 Directly Activates Caspase-9 in Endoplasmic Reticulum Stress–Induced Apoptosis in SH-SY5Y Cells

Journal of Pharmacological Sciences, 2011
The present study investigated the function of caspase-4 in endoplasmic reticulum (ER) stress–induced apoptosis in human neuronal cell line SH-SY5Y.
Akiko Yamamuro, Takashi Kishino, Yu Ohshima, Yasuhiro Yoshioka, Tomoki Kimura, Atsushi Kasai, Sadaaki Maeda   +6 more
doaj   +6 more sources

Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11 [PDF]

Nature Communications, 2018
Lipid A from some bacteria is sensed differently by humans and mice for the activation of the inflammasomes and inflammatory responses, but the mechanisms are not clear.
Brice Lagrange, Sacha Benaoudia, Pierre Wallet, Flora Magnotti, Angelina Provost, Fanny Michal, Amandine Martin, Flaviana Di Lorenzo, Bénédicte F. Py, Antonio Molinaro, Thomas Henry   +10 more
doaj   +7 more sources

Caspase-4 Is Required for Activation of Inflammasomes [PDF]

The Journal of Immunology, 2012
Abstract IL-1β and IL-18 are crucial regulators of inflammation and immunity. Both cytokines are initially expressed as inactive precursors, which require processing by the protease caspase-1 for biological activity. Caspase-1 itself is activated in different innate immune complexes called inflammasomes.
Sollberger, Gabriel, Strittmatter, Gerhard E., Kistowska, Magdalena, French, Lars E., Beer, Hans Dietmar   +4 more
openaire   +5 more sources

Beclin1 controls caspase-4 inflammsome activation and pyroptosis in mouse myocardial reperfusion-induced microvascular injury [PDF]

Cell Communication and Signaling, 2021
Background Myocardial reperfusion injury is often accompanied by cell death and inflammatory reactions. Recently, pyroptosis is gradually recognized as pivotal role in cardiovascular disease.
Wenjing Sun, Hongquan Lu, Shujuan Dong, Rui Li, Yingjie Chu, Nan Wang, Yu Zhao, Yabin Zhang, Limeiting Wang, Lin Sun, Di Lu   +10 more
doaj   +2 more sources

Estimation of noncanonical pyroptosis biomarkers gasdermin D and caspase 4 in gingiva of periodontitis and diabetes patients: An observational cross-sectional study

Journal of Indian Society of Periodontology
Background: Periodontitis and diabetes are chronic diseases where inflammation plays a central role, with each condition exacerbating the other. Pyroptosis, an inflammatory form of programmed cell death, is implicated in periodontitis and diabetes.
Lalitha Tanjore Arunachalam, Snophia Suresh, Vamsi Lavu, Shankarram Vedamanickam, John Ebinezer, Bhavishya Balachandran   +5 more
doaj   +2 more sources

Interleukin-17F suppressed colon cancer by enhancing caspase 4 mediated pyroptosis of endothelial cells [PDF]

Scientific Reports
The combination of anti-angiogenic treatment and immunotherapy presents a promising strategy against colon cancer. Interleukin-17F (IL-17F) emerges as a critical immune cell cytokine expressed in colonic epithelial cells, demonstrating potential in ...
Ying Zhou, Mei Yang, Rishun Fu, Weihuang Liu, Zihan Cai, Hanyu Lin, Siheng Li, Chuanyu Zong, Yun Chen, Zan Tong   +9 more
doaj   +2 more sources

The colonic pathogen Entamoeba histolytica activates caspase-4/1 that cleaves the pore-forming protein gasdermin D to regulate IL-1β secretion. [PDF]

PLoS Pathogens, 2022
A hallmark of Entamoeba histolytica (Eh) invasion in the gut is acute inflammation dominated by the secretion of pro-inflammatory cytokines TNF-α and IL-1β.
Shanshan Wang, France Moreau, Kris Chadee   +2 more
doaj   +2 more sources

Gasdermin-D pores induce an inactivating caspase-4 cleavage that limits IL-18 production in the intestinal epithelium [PDF]

Communications Biology
Intestinal epithelial-derived IL-18 is critical for homeostatic intestinal barrier function and is secreted through Gasdermin D (GSDMD) pores. Inflammasome activation is a prerequisite for both IL-18 maturation and GSDMD pore formation.
J. K. Bruce, L. Y. Li, Y. Tang, E. Forster, N. J. Winsor, P. Y. Bi, C. Krustev, S. Keely, J. E. Lee, J. R. Rohde, H. Y. Gaisano, D. J. Philpott, S. E. Girardin   +12 more
doaj   +2 more sources

Protective role of Cop in Rip2/Caspase-1/Caspase-4-mediated HeLa cell death

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2006
CARD only protein (Cop) was recently identified as a protein with significant homology with the CARD of caspase-1. We have conducted functional studies on Cop and report on its role as an inhibitor of cell death in a broad range of cell death paradigms. A notable exception in the ability of Cop to inhibit cell death pertains to its inability to inhibit
X. Wang, M. Narayanan, J. M. Bruey, D. Rigamonti, E. Cattaneo, J. C. Reed, R. M. Friedlander   +6 more
openaire   +3 more sources

Noncanonical Inflammasome Activation of Caspase-4/Caspase-11 Mediates Epithelial Defenses against Enteric Bacterial Pathogens [PDF]

Cell Host & Microbe, 2014
Inflammasome-mediated host defenses have been extensively studied in innate immune cells. Whether inflammasomes function for innate defense in intestinal epithelial cells, which represent the first line of defense against enteric pathogens, remains unknown.
Knodler, Leigh A, Crowley, Shauna M, Sham, Ho Pan, Yang, Hyungjun, Wrande, Marie, Ma, Caixia, Ernst, Robert K, Steele-Mortimer, Olivia, Celli, Jean, Vallance, Bruce A   +9 more
openaire   +4 more sources