Results 41 to 50 of about 332,821 (272)
New insights into the noncanonical inflammasome point to caspase-4 as a druggable target. [PDF]
Nat Rev ImmunolRecent studies indicate that the human lipopolysaccharide sensor caspase-4, unlike its mouse homologue caspase-11, is constitutively expressed and activates pro-IL-18 as well as gasdermin D-mediated pyroptosis. Activation of human caspase-4 causes vascular leakage systemically and at the blood-brain barrier in mice and is implicated in the pathogenesis
Elkayam E +4 more
europepmc +3 more sources
Caspase-3 content in SNU-1 cells.
, 2021 Increase in intracellular Caspase-3 compared to blank (untreated) SNU-1 cells upon treatment with 50–5000 nm sized aminated, carboxylated and NF particles for 4 h. Data compared with respect to surface functionalization (A) or particle size (B). All data
Amrita Banerjee (382658) +2 more
core +1 more source
Function and Regulation of Noncanonical Caspase-4/5/11 Inflammasome [PDF]
The Journal of Immunology, 2020 Abstract Inflammasomes are multiprotein complexes of the innate immune system that orchestrate development of inflammation by activating the secretion of proinflammatory cytokines, IL-1β and IL-18. The LPS of Gram-negative bacteria have been shown to activate a novel, noncanonical inflammasome by directly binding in the cytosol to human ...
Sampsa Matikainen +2 more
openaire +2 more sources
Caspase-4 regulates cell death in STM-infected PMN-HIOs.
, 2022 A. Representative fluorescence microscopy images of TUNEL staining of PMN-HIO frozen histology sections. HIOs were microinjected with STM and co-cultured with PMNs in the presence of inhibitors for Caspase-4 (z-LEVD) (20 μM), or DMSO control.
David R. Hill (2330602) +13 more
core +1 more source
mSystems, 2021 Macrophages and monocytes are innate immune cells playing an important role in orchestrating the initial innate immune response to bacterial infection and the tissue damage.
Orna Ernst +11 more
doaj +1 more source
Anti-GBM glomerulonephritis involves IL-1 but is independent of NLRP3/ASC inflammasome-mediated activation of caspase-1 [PDF]
, 2011 IL-1b and IL-18 are proinflammatory cytokines that contribute to renal immune complex disease, but whether IL-1b and IL-18 are mediators of intrinsic glomerular inflammation is unknown.
Volker Vielhauer +47 more
core +1 more source
Caspase-8 is upstream of caspase-1 in the death pathway of Ripk1D325A/D325A mice at E10.5.
, 2021 (A and B) IF staining of E10.5 YS with anti-PECAM (red) and anti-Cl.CASP1 (green) antibodies. Scale bars, 50 μm. Images are representative of 4 embryos per genotype.
Ye-hsuan Sun (11338002) +12 more
core +1 more source
NF-κB regulates caspase-4 expression and sensitizes neuroblastoma cells to Fas-induced apoptosis. [PDF]
PLoS ONE, 2015 Found in neurons and neuroblastoma cells, Fas-induced apoptosis and accompanied activation of NF-κB signaling were thought to be associated with neurodegenerative diseases. However, the detailed functions of NF-κB activation in Fas killing and the effect
Hai-Jie Yang +5 more
doaj +1 more source
Caspase-mediated Specific Cleavage of Human Histone Deacetylase 4 [PDF]
Journal of Biological Chemistry, 2004 Histone deacetylase 4 (HDAC4) is a class II HDAC implicated in controlling gene expression important for diverse cellular functions, but little is known about how its expression and stability are regulated. We report here that this deacetylase is unusually unstable, with a half-life of less than 8 h.
Fang, Liu +3 more
openaire +2 more sources
Caspase-8 content in SNU-1 cells.
, 2021 Increases in intracellular Caspase-8 compared to blank (untreated) SNU-1 cells upon treatment with 50–5000 nm sized aminated, carboxylated and NF particles for 4 h. Data compared with respect to surface functionalization (A) or particle size (B).
Amrita Banerjee (382658) +2 more
core +1 more source