Results 21 to 30 of about 332,821 (272)

Entamoeba histolytica-Induced Caspase-4 Activation Regulates IL-1β Secretion Through Caspase-1

, 2018
Entamoeba histolytica (Eh) is the causative agent of amebiasis, one of the top four parasitic causes of mortality worldwide. In 90% of infected individuals, Eh harmlessly colonizes the large intestine and results in a non-invasive and asymptomatic infection.
Quach, Jeanie
openaire   +3 more sources

Inflammation in Hypervolemic Hemodialysis Patients: The Roles of RelB and Caspase-4. [PDF]

Int J Mol Sci, 2023
Hypervolemia is associated with inflammation in hemodialysis (HD) patients. How hypervolemia triggers inflammation is not entirely known. We initiated a cross-sectional study enrolling 40 hemodialysis patients who were categorized into normovolemic (N; 23) and hypervolemic (H; 17) groups by bioimpedance measurement.
Ulrich C, Canim Z, Herberger E, Girndt M, Fiedler R.   +4 more
europepmc   +4 more sources

Structural insights into cytokine cleavage by inflammatory caspase-4. [PDF]

Nature, 2023
Inflammatory caspases are key enzymes in mammalian innate immunity that control the processing and release of interleukin-1 (IL-1)-family cytokines1,2. Despite the biological importance, the structural basis for inflammatory caspase-mediated cytokine processing has remained unclear.
Devant P, Dong Y, Mintseris J, Ma W, Gygi SP, Wu H, Kagan JC.   +6 more
europepmc   +3 more sources

FE65 Binds Teashirt, Inhibiting Expression of the Primate-Specific Caspase-4

PLoS ONE, 2009
The Alzheimer disease (AD) amyloid protein precursor (APP) can bind the FE65 adaptor protein and this complex can regulate gene expression. We carried out yeast two-hybrid studies with a PTB domain of FE65, focusing on those genes that might be involved in nuclear signaling, and identified and validated Teashirt proteins as FE65 interacting proteins in
Yuji Kajiwara, Afia Akram, Pavel Katsel, Vahram Haroutunian, James Schmeidler, Gary Beecham, Jonathan L Haines, Margaret A Pericak-Vance, Joseph D Buxbaum   +8 more
openaire   +5 more sources

Resurrection of an ancient inflammatory locus reveals switch to caspase-1 specificity on a caspase-4 scaffold. [PDF]

J Biol Chem, 2022
Pyroptosis is a mechanism of inflammatory cell death mediated by the activation of the prolytic protein gasdermin D by caspase-1, caspase-4, and caspase-5 in human, and caspase-1 and caspase-11 in mouse. In addition, caspase-1 amplifies inflammation by proteolytic activation of cytokine interleukin-1β (IL-1β). Modern mammals of the order Carnivora lack
Bibo-Verdugo B, Joglekar I, Karadi Giridhar MN, Ramirez ML, Snipas SJ, Clark AC, Poreba M, Salvesen GS.   +7 more
europepmc   +3 more sources

Noncanonical Roles of Caspase-4 and Caspase-5 in Heme-Driven IL-1β Release and Cell Death. [PDF]

J Immunol, 2021
Abstract Excessive release of heme from RBCs is a key pathophysiological feature of several disease states, including bacterial sepsis, malaria, and sickle cell disease. This hemolysis results in an increased level of free heme that has been implicated in the inflammatory activation of monocytes, macrophages, and the endothelium.
Bolívar BE, Brown-Suedel AN, Rohrman BA, Charendoff CI, Yazdani V, Belcher JD, Vercellotti GM, Flanagan JM, Bouchier-Hayes L.   +8 more
europepmc   +4 more sources

Neutrophils Orchestrate the Periodontal Pocket

Frontiers in Immunology, 2021
The subgingival biofilm attached to tooth surfaces triggers and maintains periodontitis. Previously, late-onset periodontitis has been considered a consequence of dysbiosis and a resultant polymicrobial disruption of host homeostasis.
Ljubomir Vitkov, Ljubomir Vitkov, Luis E. Muñoz, Luis E. Muñoz, Janina Schoen, Janina Schoen, Jasmin Knopf, Jasmin Knopf, Christine Schauer, Christine Schauer, Bernd Minnich, Martin Herrmann, Martin Herrmann, Matthias Hannig   +13 more
doaj   +1 more source

Evolutionary loss of inflammasomes in the Carnivora and implications for the carriage of zoonotic infections

Cell Reports, 2021
Summary: Zoonotic pathogens, such as COVID-19, reside in animal hosts before jumping species to infect humans. The Carnivora, like mink, carry many zoonoses, yet how diversity in host immune genes across species affect pathogen carriage is poorly ...
Zsofi Digby, Panagiotis Tourlomousis, James Rooney, Joseph P. Boyle, Betsaida Bibo-Verdugo, Robert J. Pickering, Steven J. Webster, Thomas P. Monie, Lee J. Hopkins, Nobuhiko Kayagaki, Guy S. Salvesen, Soren Warming, Lucy Weinert, Clare E. Bryant   +13 more
doaj   +1 more source

Caspase-4: A Therapeutic Target for Peptic Ulcer Disease [PDF]

ImmunoHorizons, 2020
Abstract Peptic ulcers are caused by the interaction between bacterial and host factors. This study demonstrates enhanced expression of caspase-4 in peptic ulcer patient biopsies, indicating that pyroptosis and noncanonical inflammasome activity may be processes involved in peptic ulcer disease.
Zbigniew Zaslona, Ewelina Flis, Ciara Nulty, Jay Kearney, Rebecca Fitzgerald, Atiyekeogbebe R Douglas, Deirdre McNamara, Sinead Smith, Luke A J O’Neill, Emma M Creagh   +9 more
openaire   +2 more sources

Geranylgeranoic acid, a bioactive and endogenous fatty acid in mammals: a review

Journal of Lipid Research, 2023
Geranylgeranoic acid (GGA) was first reported in 1983 as one of the mevalonic acid metabolites, but its biological significance was not studied for a long time.
Yoshihiro Shidoji
doaj   +1 more source